The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues
We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats’ paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2010
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| Online Access: | http://eprints.um.edu.my/7966/1/The_inhibitory_effects_of_Gelam.pdf |
| _version_ | 1825719461392416768 |
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| author | Kassim, Mustafa Achoui, Mouna Mansor, Marzida Yusoff, Kamaruddin Mohd |
| author_facet | Kassim, Mustafa Achoui, Mouna Mansor, Marzida Yusoff, Kamaruddin Mohd |
| author_sort | Kassim, Mustafa |
| collection | UM |
| description | We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats’ paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were able to inhibit edema and pain in inflammatory tissues as well as showing potent inhibitory activities against NO and PGE2 in both models. The decrease in edema and pain correlates with the inhibition of NO and PGE2. Phenolic compounds have been implicated in the inhibitory activities. Honey is potentially useful in the treatment of inflammatory conditions. |
| first_indexed | 2024-03-06T05:20:06Z |
| format | Article |
| id | um.eprints-7966 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:20:06Z |
| publishDate | 2010 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-79662019-11-11T02:46:47Z http://eprints.um.edu.my/7966/ The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues Kassim, Mustafa Achoui, Mouna Mansor, Marzida Yusoff, Kamaruddin Mohd R Medicine We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats’ paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were able to inhibit edema and pain in inflammatory tissues as well as showing potent inhibitory activities against NO and PGE2 in both models. The decrease in edema and pain correlates with the inhibition of NO and PGE2. Phenolic compounds have been implicated in the inhibitory activities. Honey is potentially useful in the treatment of inflammatory conditions. Elsevier 2010 Article PeerReviewed application/pdf en http://eprints.um.edu.my/7966/1/The_inhibitory_effects_of_Gelam.pdf Kassim, Mustafa and Achoui, Mouna and Mansor, Marzida and Yusoff, Kamaruddin Mohd (2010) The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues. Fitoterapia, 81 (8). pp. 1196-1201. ISSN 0367-326X, DOI https://doi.org/10.1016/j.fitote.2010.07.024 <https://doi.org/10.1016/j.fitote.2010.07.024>. https://doi.org/10.1016/j.fitote.2010.07.024 doi:10.1016/j.fitote.2010.07.024 |
| spellingShingle | R Medicine Kassim, Mustafa Achoui, Mouna Mansor, Marzida Yusoff, Kamaruddin Mohd The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues |
| title | The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues |
| title_full | The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues |
| title_fullStr | The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues |
| title_full_unstemmed | The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues |
| title_short | The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues |
| title_sort | inhibitory effects of gelam honey and its extracts on nitric oxide and prostaglandin e2 in inflammatory tissues |
| topic | R Medicine |
| url | http://eprints.um.edu.my/7966/1/The_inhibitory_effects_of_Gelam.pdf |
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