Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide
The nucleophilic second-order rate constant (kappa(OH)) for the reaction of OH- with N-benzylphthalimide appears to follow a reaction mechanism similar to that for reactions of OH with phthalimide and its N-alkylphthalimides. The rate of hydrolysis reveals an insignificant contribution of water-cata...
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| Format: | Article |
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2005
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| author | Ariffin, Azhar Khan, M.N. Ye, C.M. |
| author_facet | Ariffin, Azhar Khan, M.N. Ye, C.M. |
| author_sort | Ariffin, Azhar |
| collection | UM |
| description | The nucleophilic second-order rate constant (kappa(OH)) for the reaction of OH- with N-benzylphthalimide appears to follow a reaction mechanism similar to that for reactions of OH with phthalimide and its N-alkylphthalimides. The rate of hydrolysis reveals an insignificant contribution of water-catalysed cleavage of NBPT compared with its hydroxide ion catalysed reaction. The observed pseudo first-order rate constant, kappa(obs), for alkaline hydrolysis of NBPT decreases with increase in the content of organic cosolvents (up to 70%, nu/nu) in mixed water-CH3CN and water-DMF solvents. |
| first_indexed | 2024-03-06T05:20:19Z |
| format | Article |
| id | um.eprints-8046 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:20:19Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | um.eprints-80462019-08-27T06:05:29Z http://eprints.um.edu.my/8046/ Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide Ariffin, Azhar Khan, M.N. Ye, C.M. QD Chemistry The nucleophilic second-order rate constant (kappa(OH)) for the reaction of OH- with N-benzylphthalimide appears to follow a reaction mechanism similar to that for reactions of OH with phthalimide and its N-alkylphthalimides. The rate of hydrolysis reveals an insignificant contribution of water-catalysed cleavage of NBPT compared with its hydroxide ion catalysed reaction. The observed pseudo first-order rate constant, kappa(obs), for alkaline hydrolysis of NBPT decreases with increase in the content of organic cosolvents (up to 70%, nu/nu) in mixed water-CH3CN and water-DMF solvents. 2005 Article PeerReviewed Ariffin, Azhar and Khan, M.N. and Ye, C.M. (2005) Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide. Indian Journal of Chemistry Section a-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry, 44 (10). pp. 2055-2059. ISSN 0376-4710, http://cat.inist.fr/?aModele=afficheN&cpsidt=17165667 |
| spellingShingle | QD Chemistry Ariffin, Azhar Khan, M.N. Ye, C.M. Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide |
| title | Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide |
| title_full | Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide |
| title_fullStr | Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide |
| title_full_unstemmed | Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide |
| title_short | Solvent Effects On Alkaline Hydrolysis Of N-Benzylphthalimide In Mixed Water-Acetonitrile And Mixed Water-N,N-Dimethylformamide |
| title_sort | solvent effects on alkaline hydrolysis of n benzylphthalimide in mixed water acetonitrile and mixed water n n dimethylformamide |
| topic | QD Chemistry |
| work_keys_str_mv | AT ariffinazhar solventeffectsonalkalinehydrolysisofnbenzylphthalimideinmixedwateracetonitrileandmixedwaternndimethylformamide AT khanmn solventeffectsonalkalinehydrolysisofnbenzylphthalimideinmixedwateracetonitrileandmixedwaternndimethylformamide AT yecm solventeffectsonalkalinehydrolysisofnbenzylphthalimideinmixedwateracetonitrileandmixedwaternndimethylformamide |