Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid
The values of pseudo first-order rate constants, k(1), for the O-cyclization and k(3) for N-cyclization of N-benzylphthalamic acid 1, obtained at 0.02M HCl and 35 degrees C, show a respective nonlinear increase from 17.6 x 10(-6) to 29.7 x 10(-6) s(-1) and decrease from 12.5 x 10(-7) to 3.75 x 10(-7...
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| Format: | Article |
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2008
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| author | Ariffin, Azhar Khan, M.N. Cheong, M.Y. |
| author_facet | Ariffin, Azhar Khan, M.N. Cheong, M.Y. |
| author_sort | Ariffin, Azhar |
| collection | UM |
| description | The values of pseudo first-order rate constants, k(1), for the O-cyclization and k(3) for N-cyclization of N-benzylphthalamic acid 1, obtained at 0.02M HCl and 35 degrees C, show a respective nonlinear increase from 17.6 x 10(-6) to 29.7 x 10(-6) s(-1) and decrease from 12.5 x 10(-7) to 3.75 x 10(-7) s(-1) with increase in the CH(3)CN content from 2 to 60% v/v in mixed aqueous solvent. Increase in the CH3CN content from 60 to 90% v/v decreases k(1) from 29.7 x 10(-6) to 24.4 x 10(-6) s(-1) and increases k(3) from 3.75 x 10(-7) to 14.7 x 10(-7) s(-1). The respective values of k(1) and k(3) decrease nonlinearly from 16.0 x 10(-6) to 3.0 x 10(-6) s(-1), and 14.0 x 10(-7) to similar to 4.0 x 10(-7) s(-1) with increase in the content of N,N-dimethyl-formamide (HCONMe(2)) from 2 to 80% v/v in mixed aqueous solvents. These results indicate rather mild rate-retarding effects of mixed H(2)O-CH(3)CN and H(2)O-HCONMe(2) solvents on the rates of the intramolecular reactions. |
| first_indexed | 2024-03-06T05:20:20Z |
| format | Article |
| id | um.eprints-8054 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:20:20Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | um.eprints-80542019-08-27T06:17:39Z http://eprints.um.edu.my/8054/ Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid Ariffin, Azhar Khan, M.N. Cheong, M.Y. QD Chemistry The values of pseudo first-order rate constants, k(1), for the O-cyclization and k(3) for N-cyclization of N-benzylphthalamic acid 1, obtained at 0.02M HCl and 35 degrees C, show a respective nonlinear increase from 17.6 x 10(-6) to 29.7 x 10(-6) s(-1) and decrease from 12.5 x 10(-7) to 3.75 x 10(-7) s(-1) with increase in the CH(3)CN content from 2 to 60% v/v in mixed aqueous solvent. Increase in the CH3CN content from 60 to 90% v/v decreases k(1) from 29.7 x 10(-6) to 24.4 x 10(-6) s(-1) and increases k(3) from 3.75 x 10(-7) to 14.7 x 10(-7) s(-1). The respective values of k(1) and k(3) decrease nonlinearly from 16.0 x 10(-6) to 3.0 x 10(-6) s(-1), and 14.0 x 10(-7) to similar to 4.0 x 10(-7) s(-1) with increase in the content of N,N-dimethyl-formamide (HCONMe(2)) from 2 to 80% v/v in mixed aqueous solvents. These results indicate rather mild rate-retarding effects of mixed H(2)O-CH(3)CN and H(2)O-HCONMe(2) solvents on the rates of the intramolecular reactions. 2008 Article PeerReviewed Ariffin, Azhar and Khan, M.N. and Cheong, M.Y. (2008) Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid. Progress in Reaction Kinetics and Mechanism, 33 (2). pp. 167-190. ISSN 1468-6783, DOI https://doi.org/10.3184/146867808x315733 <https://doi.org/10.3184/146867808x315733>. http://www.ingentaconnect.com/content/stl/prk/2008/00000033/00000002/art00003?token=005c1e1a808f23f10ac5367e41225f40384d2c20415d483f67622c3a576b34272c5f7b3d6d3f4e4b346debf11f5f 10.3184/146867808x315733 |
| spellingShingle | QD Chemistry Ariffin, Azhar Khan, M.N. Cheong, M.Y. Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid |
| title | Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid |
| title_full | Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid |
| title_fullStr | Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid |
| title_full_unstemmed | Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid |
| title_short | Effects of mixed H(2)O-CH(3)CN and H(2)O-Hconme(2) solvents on the rate of cleavage of N-Benzylphthalamic Acid |
| title_sort | effects of mixed h 2 o ch 3 cn and h 2 o hconme 2 solvents on the rate of cleavage of n benzylphthalamic acid |
| topic | QD Chemistry |
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