| Summary: | A series of novel 3-(4-substituted piperazin-1-yl)alkylimidazo2,1-b1,3benzothiazol-2(3H)-ones were prepared by microwave irradiation using alumina as solid support and also by a conventional method. The compounds were characterized by spectral data and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-hydroxytryptamine(3) antagonisms in a longitudinal muscle-myenteric plexus preparation from guinea pig ileum against the 5-hydroxytryptamine3 agonist, 2-methyl-5-hydroxytryptamine. Among the test compounds, 3-2-(4-methylpiperazin-1-yl)ethylimidazo2,1-b1,3benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA(2) 6.7) in the isolated guinea pig ileum.
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