CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice
The present study was designed to evaluate CNS depression or analeptic activity of acute oral administration of methanol (ACME) and acetone (ACAE) extracts of Acorus calamus leaves in mice. Spontaneous locomotor activity, immobility time using forced swim test, diazepam-induced sleeping time and mot...
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| Format: | Article |
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2009
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| author | Pandi, P.V. Jose, N. Subhash, H. |
| author_facet | Pandi, P.V. Jose, N. Subhash, H. |
| author_sort | Pandi, P.V. |
| collection | UM |
| description | The present study was designed to evaluate CNS depression or analeptic activity of acute oral administration of methanol (ACME) and acetone (ACAE) extracts of Acorus calamus leaves in mice. Spontaneous locomotor activity, immobility time using forced swim test, diazepam-induced sleeping time and motor impairment assessment using rotarod were used to assess CNS depression/analeptic activity of ACME and ACAE in mice. The extracts ACME (5, 20 and 50 mg kg-1, p.o.) and ACAE (20 and 50 mg kg-1, p.o.) significantly decreased the spontaneous locomotor activity in dose dependent manner. The acute treatment of ACME and ACAE (5, 20 and 50 mg kg-1, p.o.) significantly increased the immobility time and decreased the swimming behavior. Administration 6 h prior of ACME (50 mg kg-1, p.o.) and ACAE (20 and 50 mg kg-1, p.o.) significantly potentiated the diazepam (25 mg kg-1, i.p.)-induced sleeping time in mice. These extracts did not induce disturbance in motor coordination. The results of the present research provided evidences that ACME and ACAE may contain psychoactive substances that are CNS depressant in nature. The CNS depression property of these extracts can be utilized for further anticonvulsant research. |
| first_indexed | 2024-03-06T05:20:35Z |
| format | Article |
| id | um.eprints-8147 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:20:35Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | um.eprints-81472013-07-22T01:39:22Z http://eprints.um.edu.my/8147/ CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice Pandi, P.V. Jose, N. Subhash, H. R Medicine The present study was designed to evaluate CNS depression or analeptic activity of acute oral administration of methanol (ACME) and acetone (ACAE) extracts of Acorus calamus leaves in mice. Spontaneous locomotor activity, immobility time using forced swim test, diazepam-induced sleeping time and motor impairment assessment using rotarod were used to assess CNS depression/analeptic activity of ACME and ACAE in mice. The extracts ACME (5, 20 and 50 mg kg-1, p.o.) and ACAE (20 and 50 mg kg-1, p.o.) significantly decreased the spontaneous locomotor activity in dose dependent manner. The acute treatment of ACME and ACAE (5, 20 and 50 mg kg-1, p.o.) significantly increased the immobility time and decreased the swimming behavior. Administration 6 h prior of ACME (50 mg kg-1, p.o.) and ACAE (20 and 50 mg kg-1, p.o.) significantly potentiated the diazepam (25 mg kg-1, i.p.)-induced sleeping time in mice. These extracts did not induce disturbance in motor coordination. The results of the present research provided evidences that ACME and ACAE may contain psychoactive substances that are CNS depressant in nature. The CNS depression property of these extracts can be utilized for further anticonvulsant research. 2009 Article PeerReviewed Pandi, P.V. and Jose, N. and Subhash, H. (2009) CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice. Journal of Pharmacology and Toxicology, 4 (2). pp. 79-86. ISSN 1816-496X, |
| spellingShingle | R Medicine Pandi, P.V. Jose, N. Subhash, H. CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice |
| title | CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice |
| title_full | CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice |
| title_fullStr | CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice |
| title_full_unstemmed | CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice |
| title_short | CNS activity of methanol and acetone extracts of Acorus calamus leaves in mice |
| title_sort | cns activity of methanol and acetone extracts of acorus calamus leaves in mice |
| topic | R Medicine |
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