Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites

Oxidative stress has been implicated as an important pathogenic factor in the pathophysiology Of various life-threatening diseases such as cancer, cardiovascular diseases and diabetes. It occurs when the production of free radicals (generated during aerobic metabolism, inflammation, and infections)...

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Main Authors: Chandramathi, S., Suresh, K., Anita, Z.B., Kuppusamy, U.R.
Format: Article
Language:English
Published: 2009
Subjects:
Online Access:http://eprints.um.edu.my/8194/1/Chandramathi-2009-Elevated_levels_of_u.pdf
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author Chandramathi, S.
Suresh, K.
Anita, Z.B.
Kuppusamy, U.R.
author_facet Chandramathi, S.
Suresh, K.
Anita, Z.B.
Kuppusamy, U.R.
author_sort Chandramathi, S.
collection UM
description Oxidative stress has been implicated as an important pathogenic factor in the pathophysiology Of various life-threatening diseases such as cancer, cardiovascular diseases and diabetes. It occurs when the production of free radicals (generated during aerobic metabolism, inflammation, and infections) overcome the antioxidant defences in the body. Although previous Studies have implied that oxidative stress is present in serum of patients with parasitic infection there have been no Studies confirming oxidative stress levels in the Malaysian population infected with intestinal parasites. Three biochemical assays namely hydrogen peroxide (H(2)O(2)), lipid peroxidation (LP) and advanced oxidative protein product (AOPP) assays Were carried out to measure oxidative stress levels in the urine of human subjects whose stools,were infected with parasites Such as Blastocystis hominis, Ascaris, Trichuris, hookworm and microsporidia. The levels of H(2)O(2), AOPP and LP were Significantly higher (P<0.001, P<0.05 and P<0.05 respectively) in the parasite-infected subjects (n = 75) compared to the controls (n = 95). In conclusion, the study provides evidence that oxidative stress is elevated in humans infected by intestinal parasites. This study may influence future researchers to consider free radical-related pathways to be a target in the interventions of new drugs against parasitic infection and related diseases.
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spelling um.eprints-81942013-08-14T00:46:59Z http://eprints.um.edu.my/8194/ Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites Chandramathi, S. Suresh, K. Anita, Z.B. Kuppusamy, U.R. R Medicine Oxidative stress has been implicated as an important pathogenic factor in the pathophysiology Of various life-threatening diseases such as cancer, cardiovascular diseases and diabetes. It occurs when the production of free radicals (generated during aerobic metabolism, inflammation, and infections) overcome the antioxidant defences in the body. Although previous Studies have implied that oxidative stress is present in serum of patients with parasitic infection there have been no Studies confirming oxidative stress levels in the Malaysian population infected with intestinal parasites. Three biochemical assays namely hydrogen peroxide (H(2)O(2)), lipid peroxidation (LP) and advanced oxidative protein product (AOPP) assays Were carried out to measure oxidative stress levels in the urine of human subjects whose stools,were infected with parasites Such as Blastocystis hominis, Ascaris, Trichuris, hookworm and microsporidia. The levels of H(2)O(2), AOPP and LP were Significantly higher (P<0.001, P<0.05 and P<0.05 respectively) in the parasite-infected subjects (n = 75) compared to the controls (n = 95). In conclusion, the study provides evidence that oxidative stress is elevated in humans infected by intestinal parasites. This study may influence future researchers to consider free radical-related pathways to be a target in the interventions of new drugs against parasitic infection and related diseases. 2009 Article PeerReviewed application/pdf en http://eprints.um.edu.my/8194/1/Chandramathi-2009-Elevated_levels_of_u.pdf Chandramathi, S. and Suresh, K. and Anita, Z.B. and Kuppusamy, U.R. (2009) Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites. Parasitology, 136 (3). pp. 359-363. ISSN 0031-1820, DOI https://doi.org/10.1017/s0031182008005465 <https://doi.org/10.1017/s0031182008005465>. http://www.ncbi.nlm.nih.gov/pubmed/19154644 10.1017/s0031182008005465
spellingShingle R Medicine
Chandramathi, S.
Suresh, K.
Anita, Z.B.
Kuppusamy, U.R.
Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites
title Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites
title_full Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites
title_fullStr Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites
title_full_unstemmed Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites
title_short Elevated levels of urinary hydrogen peroxide, advanced oxidative protein product (AOPP) and malondialdehyde in humans infected with intestinal parasites
title_sort elevated levels of urinary hydrogen peroxide advanced oxidative protein product aopp and malondialdehyde in humans infected with intestinal parasites
topic R Medicine
url http://eprints.um.edu.my/8194/1/Chandramathi-2009-Elevated_levels_of_u.pdf
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