Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy
Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged 20 years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan Meier and Cox regression...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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2013
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| Online Access: | http://eprints.um.edu.my/8271/1/Predictors_of_death_in_Malaysia_HIV.pdf |
| _version_ | 1825719514133692416 |
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| author | Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. |
| author_facet | Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. |
| author_sort | Lubis, R. |
| collection | UM |
| description | Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged 20 years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan Meier and Cox regression analyses. Results: 72.7 of the patients survived. Multivariate Cox regression showed that significant predictors of death were age 50 years (HR 1.76; 95 CI 1.18 2.64), secondary education (HR 3.57; 95 CI 1.12 11.37), tertiary education (HR 3.57; 95 CI 1.0911.70), being unemployed (HR 1.49; 95 CI 1.07 2.09), AIDS on initial presentation (HR 5.75; 95 CI 3.29 10.07), single-drug ART (HR 1.84; 95 CI 1.27, 2.66), double-drug ART (HR 1.63; 95 CI 1.19 2.25) and inability to achieve viral load 50 copies/ml (HR 10.22; 95 CI 7.26 14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients. |
| first_indexed | 2024-03-06T05:20:55Z |
| format | Article |
| id | um.eprints-8271 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:20:55Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | um.eprints-82712013-08-19T02:10:37Z http://eprints.um.edu.my/8271/ Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. R Medicine Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged 20 years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan Meier and Cox regression analyses. Results: 72.7 of the patients survived. Multivariate Cox regression showed that significant predictors of death were age 50 years (HR 1.76; 95 CI 1.18 2.64), secondary education (HR 3.57; 95 CI 1.12 11.37), tertiary education (HR 3.57; 95 CI 1.0911.70), being unemployed (HR 1.49; 95 CI 1.07 2.09), AIDS on initial presentation (HR 5.75; 95 CI 3.29 10.07), single-drug ART (HR 1.84; 95 CI 1.27, 2.66), double-drug ART (HR 1.63; 95 CI 1.19 2.25) and inability to achieve viral load 50 copies/ml (HR 10.22; 95 CI 7.26 14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients. 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/8271/1/Predictors_of_death_in_Malaysia_HIV.pdf Lubis, R. and Bulgiba, A. and Kamarulzaman, A. and Hairi, N.N. and Dahlui, M. and Peramalah, D. (2013) Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy. Preventive medicine. ISSN 0091-7435, DOI https://doi.org/10.1016/j.ypmed.2013.01.006 <https://doi.org/10.1016/j.ypmed.2013.01.006>. http://www.sciencedirect.com/science/article/pii/S0091743513000194 10.1016/j.ypmed.2013.01.006 |
| spellingShingle | R Medicine Lubis, R. Bulgiba, A. Kamarulzaman, A. Hairi, N.N. Dahlui, M. Peramalah, D. Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title | Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_full | Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_fullStr | Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_full_unstemmed | Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_short | Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy |
| title_sort | predictors of death in malaysian hiv infected patients on anti retroviral therapy |
| topic | R Medicine |
| url | http://eprints.um.edu.my/8271/1/Predictors_of_death_in_Malaysia_HIV.pdf |
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