BODIPY dyes in photodynamic therapy
BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet stat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Royal Society of Chemistry
2013
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| Online Access: | http://eprints.um.edu.my/8524/1/Kamkaew-2013-BODIPY_dyes_in_photo.pdf |
| _version_ | 1796945758114545664 |
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| author | Kamkaew, Anyanee Lim, Siang Hui Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Burgess, Kevin |
| author_facet | Kamkaew, Anyanee Lim, Siang Hui Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Burgess, Kevin |
| author_sort | Kamkaew, Anyanee |
| collection | UM |
| description | BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with O-3(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas. |
| first_indexed | 2024-03-06T05:21:27Z |
| format | Article |
| id | um.eprints-8524 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:21:27Z |
| publishDate | 2013 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | um.eprints-85242019-11-20T01:35:24Z http://eprints.um.edu.my/8524/ BODIPY dyes in photodynamic therapy Kamkaew, Anyanee Lim, Siang Hui Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Burgess, Kevin R Medicine RS Pharmacy and materia medica BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with O-3(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas. Royal Society of Chemistry 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/8524/1/Kamkaew-2013-BODIPY_dyes_in_photo.pdf Kamkaew, Anyanee and Lim, Siang Hui and Lee, Hong Boon and Kiew, Lik Voon and Chung, Lip Yong and Burgess, Kevin (2013) BODIPY dyes in photodynamic therapy. Chemical Society Reviews, 42 (1). pp. 77-88. ISSN 0306-0012, DOI https://doi.org/10.1039/c2cs35216h <https://doi.org/10.1039/c2cs35216h>. http://pubs.rsc.org/en/content/articlepdf/2013/cs/c2cs35216h doi:10.1039/c2cs35216h |
| spellingShingle | R Medicine RS Pharmacy and materia medica Kamkaew, Anyanee Lim, Siang Hui Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Burgess, Kevin BODIPY dyes in photodynamic therapy |
| title | BODIPY dyes in photodynamic therapy |
| title_full | BODIPY dyes in photodynamic therapy |
| title_fullStr | BODIPY dyes in photodynamic therapy |
| title_full_unstemmed | BODIPY dyes in photodynamic therapy |
| title_short | BODIPY dyes in photodynamic therapy |
| title_sort | bodipy dyes in photodynamic therapy |
| topic | R Medicine RS Pharmacy and materia medica |
| url | http://eprints.um.edu.my/8524/1/Kamkaew-2013-BODIPY_dyes_in_photo.pdf |
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