Identification of bioactive compounds with GC–Q-TOF–MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction

Identification of bioactive compounds with GC–Q-TOF–MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction

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Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid...

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Bibliographic Details
Main Authors: Md Ariful Alam, Md Zaidul Islam Sarker, Kashif Ghafoor, Sahena Ferdosh, Md. Eaqub Ali, Hamed Mirhosseini, Kamaruzzaman Yunus, Md Jahurul Haque Akanda, A. Khatib
Format: Article
Language:English
Published: Taylor & Francis Group 2017
Subjects:
QK Botany
Online Access:https://eprints.ums.edu.my/id/eprint/20632/1/Identification%20of%20bioactive%20compounds%20with%20GC.pdf
Description
Summary:Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid content, and α-glucosidase inhibitory activity. An average of 3.103% yield, 98.90% antioxidant activity, 49.40 mg/g (GAE) TPC, 43.76 mg/g (RE), and 88.58% AGI activity can be achieved using the optimum levels of independent variables. The GC-Q-TOF MS identification of optimized extract shown that different classes of phytoconstituents were successfully separated by CO2-Soxhlet to produce potential antioxidant and α-glucosidase inhibitory activity.

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