High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group.
Thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in Malaysia. This paper aims to determine the prevalence of thalassemia in the Kadazandusuns, the largest indigenous group in Sabah, East Malaysia. α- and β-thalassemia were confirmed in 33.6% and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2010
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| Online Access: | https://eprints.ums.edu.my/id/eprint/21778/1/High%20Prevalence%20of%20Alpha.pdf |
| _version_ | 1825713600438730752 |
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| author | Jin-Ai Mary Anne Tan Ping-Chin Lee Yong-Chui Wee Kim-Lian Tan Noor Fadzlin Mahali Elizabeth George Kek-Heng Chua |
| author_facet | Jin-Ai Mary Anne Tan Ping-Chin Lee Yong-Chui Wee Kim-Lian Tan Noor Fadzlin Mahali Elizabeth George Kek-Heng Chua |
| author_sort | Jin-Ai Mary Anne Tan |
| collection | UMS |
| description | Thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in Malaysia. This paper aims to determine the prevalence of thalassemia in the Kadazandusuns, the largest indigenous group in Sabah, East Malaysia. α- and β-thalassemia were confirmed in 33.6% and 12.8%, of the individuals studied respectively. The high prevalence of α- and β-thalassemia in the Kadazandusuns indicates that thalassemia screening, genetic counseling, and prenatal diagnosis should be included as part of their healthcare system. This preliminary paper serves as a baseline for further investigations into the health and genetic defects of the major indigenous population in Sabah, East Malaysia. |
| first_indexed | 2024-03-06T02:59:05Z |
| format | Article |
| id | ums.eprints-21778 |
| institution | Universiti Malaysia Sabah |
| language | English |
| last_indexed | 2024-03-06T02:59:05Z |
| publishDate | 2010 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | ums.eprints-217782019-04-12T06:48:48Z https://eprints.ums.edu.my/id/eprint/21778/ High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. Jin-Ai Mary Anne Tan Ping-Chin Lee Yong-Chui Wee Kim-Lian Tan Noor Fadzlin Mahali Elizabeth George Kek-Heng Chua Thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in Malaysia. This paper aims to determine the prevalence of thalassemia in the Kadazandusuns, the largest indigenous group in Sabah, East Malaysia. α- and β-thalassemia were confirmed in 33.6% and 12.8%, of the individuals studied respectively. The high prevalence of α- and β-thalassemia in the Kadazandusuns indicates that thalassemia screening, genetic counseling, and prenatal diagnosis should be included as part of their healthcare system. This preliminary paper serves as a baseline for further investigations into the health and genetic defects of the major indigenous population in Sabah, East Malaysia. Hindawi Publishing Corporation 2010 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/21778/1/High%20Prevalence%20of%20Alpha.pdf Jin-Ai Mary Anne Tan and Ping-Chin Lee and Yong-Chui Wee and Kim-Lian Tan and Noor Fadzlin Mahali and Elizabeth George and Kek-Heng Chua (2010) High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. Journal of Biomedicine and Biotechnology. p. 5. ISSN 1110-7243 http://dx.doi.org/10.1155/2010/706872 Volume 2010, Article ID 706872, 5 pages Volume 2010, Article ID 706872, 5 pages |
| spellingShingle | Jin-Ai Mary Anne Tan Ping-Chin Lee Yong-Chui Wee Kim-Lian Tan Noor Fadzlin Mahali Elizabeth George Kek-Heng Chua High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. |
| title | High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. |
| title_full | High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. |
| title_fullStr | High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. |
| title_full_unstemmed | High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. |
| title_short | High Prevalence of Alpha- and Beta-Thalassemia in the kadazadusuns in East Malaysia: Challenges in Providing Effective Health care for an Indigenous Group. |
| title_sort | high prevalence of alpha and beta thalassemia in the kadazadusuns in east malaysia challenges in providing effective health care for an indigenous group |
| url | https://eprints.ums.edu.my/id/eprint/21778/1/High%20Prevalence%20of%20Alpha.pdf |
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