Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients

Neuroimaging is increasingly used to locate the lesion that causes cerebralpalsy (CP) and its extent in the brains of CP patients. Conventional structural magnetic resonanceimaging (MRI) does not indicate the connectional pattern of white matter; however, with the helpof diffusion MRI, fibre trackin...

Full description

Bibliographic Details
Main Authors: Safwan Samsir, Rahimah Zakaria, Salmi abdul razak, Mohamed Saat Ismail, Mohd Zulkifli abdul rahim, Chia-Shu lin, Nik Mohammad Faez Nik Osman, Mohammad Afiq Asri, Asma Hayati Ahmad
Format: Article
Language:English
Published: UniversitI Sains Malaysia 2018
Subjects:
Online Access:https://eprints.ums.edu.my/id/eprint/21899/1/Characterisation%20of%20the%20corticospinal%20tract%20using%20Diffusion%20Magnetic%20Resonance%20imaging%20in%20Unilateral%20and%20Bilateral%20Cerebral%20Palsy%20patients.pdf
_version_ 1825713613822754816
author Safwan Samsir
Rahimah Zakaria
Salmi abdul razak
Mohamed Saat Ismail
Mohd Zulkifli abdul rahim
Chia-Shu lin
Nik Mohammad Faez Nik Osman
Mohammad Afiq Asri
Asma Hayati Ahmad
author_facet Safwan Samsir
Rahimah Zakaria
Salmi abdul razak
Mohamed Saat Ismail
Mohd Zulkifli abdul rahim
Chia-Shu lin
Nik Mohammad Faez Nik Osman
Mohammad Afiq Asri
Asma Hayati Ahmad
author_sort Safwan Samsir
collection UMS
description Neuroimaging is increasingly used to locate the lesion that causes cerebralpalsy (CP) and its extent in the brains of CP patients. Conventional structural magnetic resonanceimaging (MRI) does not indicate the connectional pattern of white matter; however, with the helpof diffusion MRI, fibre tracking of white matter can be done.Methods: We used diffusion MRI and probabilistic tractography to identify the putativewhite matter connectivity in the brains of 10 CP patients. We tracked the corticospinal tract (CST)of the patients’ upper and lower limbs and calculated the white matter connectivity, as indexed bystreamlines representing the probability of connection of the CST.Results: Our results show that diffusion MRI with probabilistic tractography, while havingsome relation with the clinical diagnosis of CP, reveals a high degree of individual variation in thestreamlines representing the CST for upper and lower limbs.Conclusion: Diffusion MRI with probabilistic tractography provides the state ofconnectivity from lesioned areas to other parts of the brain and is potentially beneficial to beused as an adjunct to the clinical management of CP, providing a means to monitor interventionoutcomes.
first_indexed 2024-03-06T02:59:16Z
format Article
id ums.eprints-21899
institution Universiti Malaysia Sabah
language English
last_indexed 2024-03-06T02:59:16Z
publishDate 2018
publisher UniversitI Sains Malaysia
record_format dspace
spelling ums.eprints-218992019-05-07T00:29:13Z https://eprints.ums.edu.my/id/eprint/21899/ Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients Safwan Samsir Rahimah Zakaria Salmi abdul razak Mohamed Saat Ismail Mohd Zulkifli abdul rahim Chia-Shu lin Nik Mohammad Faez Nik Osman Mohammad Afiq Asri Asma Hayati Ahmad RC Internal medicine Neuroimaging is increasingly used to locate the lesion that causes cerebralpalsy (CP) and its extent in the brains of CP patients. Conventional structural magnetic resonanceimaging (MRI) does not indicate the connectional pattern of white matter; however, with the helpof diffusion MRI, fibre tracking of white matter can be done.Methods: We used diffusion MRI and probabilistic tractography to identify the putativewhite matter connectivity in the brains of 10 CP patients. We tracked the corticospinal tract (CST)of the patients’ upper and lower limbs and calculated the white matter connectivity, as indexed bystreamlines representing the probability of connection of the CST.Results: Our results show that diffusion MRI with probabilistic tractography, while havingsome relation with the clinical diagnosis of CP, reveals a high degree of individual variation in thestreamlines representing the CST for upper and lower limbs.Conclusion: Diffusion MRI with probabilistic tractography provides the state ofconnectivity from lesioned areas to other parts of the brain and is potentially beneficial to beused as an adjunct to the clinical management of CP, providing a means to monitor interventionoutcomes. UniversitI Sains Malaysia 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/21899/1/Characterisation%20of%20the%20corticospinal%20tract%20using%20Diffusion%20Magnetic%20Resonance%20imaging%20in%20Unilateral%20and%20Bilateral%20Cerebral%20Palsy%20patients.pdf Safwan Samsir and Rahimah Zakaria and Salmi abdul razak and Mohamed Saat Ismail and Mohd Zulkifli abdul rahim and Chia-Shu lin and Nik Mohammad Faez Nik Osman and Mohammad Afiq Asri and Asma Hayati Ahmad (2018) Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients. The Malaysian Journal of Medical Sciences, 25 (5). pp. 68-78. ISSN 1394-195X https://doi.org/10.21315/mjms2018.25.5.7
spellingShingle RC Internal medicine
Safwan Samsir
Rahimah Zakaria
Salmi abdul razak
Mohamed Saat Ismail
Mohd Zulkifli abdul rahim
Chia-Shu lin
Nik Mohammad Faez Nik Osman
Mohammad Afiq Asri
Asma Hayati Ahmad
Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients
title Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients
title_full Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients
title_fullStr Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients
title_full_unstemmed Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients
title_short Characterisation of the corticospinal tract using Diffusion Magnetic Resonance imaging in Unilateral and Bilateral Cerebral Palsy patients
title_sort characterisation of the corticospinal tract using diffusion magnetic resonance imaging in unilateral and bilateral cerebral palsy patients
topic RC Internal medicine
url https://eprints.ums.edu.my/id/eprint/21899/1/Characterisation%20of%20the%20corticospinal%20tract%20using%20Diffusion%20Magnetic%20Resonance%20imaging%20in%20Unilateral%20and%20Bilateral%20Cerebral%20Palsy%20patients.pdf
work_keys_str_mv AT safwansamsir characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT rahimahzakaria characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT salmiabdulrazak characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT mohamedsaatismail characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT mohdzulkifliabdulrahim characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT chiashulin characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT nikmohammadfaeznikosman characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT mohammadafiqasri characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients
AT asmahayatiahmad characterisationofthecorticospinaltractusingdiffusionmagneticresonanceimaginginunilateralandbilateralcerebralpalsypatients