Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease
Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conj...
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| Format: | Article |
| Language: | English |
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2018
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| Online Access: | https://eprints.ums.edu.my/id/eprint/24163/1/Molecular%20docking%20studies%20of%20coumarin%20hybrids%20as%20potential%20acetylcholinesterase.pdf |
| _version_ | 1825713764860690432 |
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| author | Samina Khan Yusufzai Mohammad Shaheen Khan Othman Sulaiman Hasnah Osman Dalily Nabilah Lamjin |
| author_facet | Samina Khan Yusufzai Mohammad Shaheen Khan Othman Sulaiman Hasnah Osman Dalily Nabilah Lamjin |
| author_sort | Samina Khan Yusufzai |
| collection | UMS |
| description | Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conjugates have been described as potential AChE, BuChE, MAO and β-amyloid inhibitors. Therefore, the objective of this review is to focus on the construction of these pharmacologically important coumarin analogues with anti-Alzheimer’s activities, highlight their docking studies and structure–activity relationships based on their substitution pattern with respect to the selected positions on the chromen ring by emphasising on the research reports conducted in between year 1968 to 2017. |
| first_indexed | 2024-03-06T03:01:37Z |
| format | Article |
| id | ums.eprints-24163 |
| institution | Universiti Malaysia Sabah |
| language | English |
| last_indexed | 2024-03-06T03:01:37Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ums.eprints-241632019-11-21T23:18:46Z https://eprints.ums.edu.my/id/eprint/24163/ Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease Samina Khan Yusufzai Mohammad Shaheen Khan Othman Sulaiman Hasnah Osman Dalily Nabilah Lamjin R Medicine (General) RC Internal medicine Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conjugates have been described as potential AChE, BuChE, MAO and β-amyloid inhibitors. Therefore, the objective of this review is to focus on the construction of these pharmacologically important coumarin analogues with anti-Alzheimer’s activities, highlight their docking studies and structure–activity relationships based on their substitution pattern with respect to the selected positions on the chromen ring by emphasising on the research reports conducted in between year 1968 to 2017. 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/24163/1/Molecular%20docking%20studies%20of%20coumarin%20hybrids%20as%20potential%20acetylcholinesterase.pdf Samina Khan Yusufzai and Mohammad Shaheen Khan and Othman Sulaiman and Hasnah Osman and Dalily Nabilah Lamjin (2018) Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease. Chemistry Central Journal, 12 (128). pp. 1-57. https://doi.org/10.1186/s13065-018-0497-z |
| spellingShingle | R Medicine (General) RC Internal medicine Samina Khan Yusufzai Mohammad Shaheen Khan Othman Sulaiman Hasnah Osman Dalily Nabilah Lamjin Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease |
| title | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease |
| title_full | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease |
| title_fullStr | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease |
| title_full_unstemmed | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease |
| title_short | Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/Band ß-amyloid inhibitors for Alzheimer’s disease |
| title_sort | molecular docking studies of coumarin hybrids as potential acetylcholinesterase butyrylcholinesterase monoamine oxidase a band ss amyloid inhibitors for alzheimer s disease |
| topic | R Medicine (General) RC Internal medicine |
| url | https://eprints.ums.edu.my/id/eprint/24163/1/Molecular%20docking%20studies%20of%20coumarin%20hybrids%20as%20potential%20acetylcholinesterase.pdf |
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