Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial
Background. Snakehead fish (Channa striatus) is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little h...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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2018
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| Online Access: | https://eprints.ums.edu.my/id/eprint/25217/1/Snakehead%20Consumption%20Enhances%20Wound%20Healing.pdf https://eprints.ums.edu.my/id/eprint/25217/7/Snakehead%20Consumption%20Enhances%20Wound%20Healing%20From%20Tradition%20to%20Modern%20Clinical%20Practice.pdf |
| _version_ | 1796910350317125632 |
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| author | Nik Amin Sahid Firdaus Hayati Challa Venkata Rao Rosnelifaizur Ramely Ikhwan Sani Andee Dzulkarnaen Zaidi Zakaria Syed Hassan Arman Zahari Aishath Azna Ali |
| author_facet | Nik Amin Sahid Firdaus Hayati Challa Venkata Rao Rosnelifaizur Ramely Ikhwan Sani Andee Dzulkarnaen Zaidi Zakaria Syed Hassan Arman Zahari Aishath Azna Ali |
| author_sort | Nik Amin Sahid |
| collection | UMS |
| description | Background. Snakehead fish (Channa striatus) is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little human study has been done to assess the effectiveness of Channa striatus in wound healing. A prospective RCT has been conducted on the effect of Channa striatus spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome. Methodology. One hundred and two patients (102) underwent clean elective surgery; postoperatively they were randomized into two group. One group received Channa striatus extract spray (n=51) another group received placebo (n=51) on daily basis for 2 weeks. They were followed up on, , and weeks. Pain control effect was assessed based on Visual Analog Pain Score (VAPS) and cosmetic outcome based on Visual Analog Cosmetic Scale (VACS), Wound Evaluation Scale (WES), and Vancouver Scar Scale (VSS). Result. The patient treated with Channa striatus spray displayed a better outcome in terms of pain control compared to placebo. During analysis using repeated measure ANOVA, there was significant difference of patient’s pain score based on VAPS between Channa striatus spray and placebo (F-stat (df) = 4.80 (2), p-value = 0.010). For cosmetic outcome it showed a better result in Channa striatus spray group for all the 3-scoring system, VACS, (F-stat (df) = 2.68 (2), p-value <0.001), WES (F-stat (df) = 3.09 (2), p-value = 0.048), and VSS (F-stat (df) = 1.72 (2), p-value = 0.011). Conclusion. Our study suggests that application of Channa striatus extract spray on clean wound has shown a significant better pain score result and cosmetic outcome on week 2, week 4, and week 6 comparatively with placebo. |
| first_indexed | 2024-03-06T03:03:09Z |
| format | Article |
| id | ums.eprints-25217 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:03:09Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ums.eprints-252172020-06-18T15:58:16Z https://eprints.ums.edu.my/id/eprint/25217/ Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial Nik Amin Sahid Firdaus Hayati Challa Venkata Rao Rosnelifaizur Ramely Ikhwan Sani Andee Dzulkarnaen Zaidi Zakaria Syed Hassan Arman Zahari Aishath Azna Ali R Medicine (General) RZ Other systems of medicine Background. Snakehead fish (Channa striatus) is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little human study has been done to assess the effectiveness of Channa striatus in wound healing. A prospective RCT has been conducted on the effect of Channa striatus spray versus placebo on clean wound to assess its pain control effect and cosmetic outcome. Methodology. One hundred and two patients (102) underwent clean elective surgery; postoperatively they were randomized into two group. One group received Channa striatus extract spray (n=51) another group received placebo (n=51) on daily basis for 2 weeks. They were followed up on, , and weeks. Pain control effect was assessed based on Visual Analog Pain Score (VAPS) and cosmetic outcome based on Visual Analog Cosmetic Scale (VACS), Wound Evaluation Scale (WES), and Vancouver Scar Scale (VSS). Result. The patient treated with Channa striatus spray displayed a better outcome in terms of pain control compared to placebo. During analysis using repeated measure ANOVA, there was significant difference of patient’s pain score based on VAPS between Channa striatus spray and placebo (F-stat (df) = 4.80 (2), p-value = 0.010). For cosmetic outcome it showed a better result in Channa striatus spray group for all the 3-scoring system, VACS, (F-stat (df) = 2.68 (2), p-value <0.001), WES (F-stat (df) = 3.09 (2), p-value = 0.048), and VSS (F-stat (df) = 1.72 (2), p-value = 0.011). Conclusion. Our study suggests that application of Channa striatus extract spray on clean wound has shown a significant better pain score result and cosmetic outcome on week 2, week 4, and week 6 comparatively with placebo. 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25217/1/Snakehead%20Consumption%20Enhances%20Wound%20Healing.pdf text en https://eprints.ums.edu.my/id/eprint/25217/7/Snakehead%20Consumption%20Enhances%20Wound%20Healing%20From%20Tradition%20to%20Modern%20Clinical%20Practice.pdf Nik Amin Sahid and Firdaus Hayati and Challa Venkata Rao and Rosnelifaizur Ramely and Ikhwan Sani and Andee Dzulkarnaen and Zaidi Zakaria and Syed Hassan and Arman Zahari and Aishath Azna Ali (2018) Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. pp. 1-9. https://doi.org/10.1155/2018/3032790 |
| spellingShingle | R Medicine (General) RZ Other systems of medicine Nik Amin Sahid Firdaus Hayati Challa Venkata Rao Rosnelifaizur Ramely Ikhwan Sani Andee Dzulkarnaen Zaidi Zakaria Syed Hassan Arman Zahari Aishath Azna Ali Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial |
| title | Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial |
| title_full | Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial |
| title_fullStr | Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial |
| title_full_unstemmed | Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial |
| title_short | Snakehead Consumption Enhances Wound Healing? From Tradition to Modern Clinical Practice: A Prospective Randomized Controlled Trial |
| title_sort | snakehead consumption enhances wound healing from tradition to modern clinical practice a prospective randomized controlled trial |
| topic | R Medicine (General) RZ Other systems of medicine |
| url | https://eprints.ums.edu.my/id/eprint/25217/1/Snakehead%20Consumption%20Enhances%20Wound%20Healing.pdf https://eprints.ums.edu.my/id/eprint/25217/7/Snakehead%20Consumption%20Enhances%20Wound%20Healing%20From%20Tradition%20to%20Modern%20Clinical%20Practice.pdf |
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