Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp.
Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12 -epi-19-O-methylscalarin (3) and methyl 18- hydroxy- 19-norscalar-16 -en-20- carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12α-OAc and 12β-OAc, and 19-olide and 20-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/25502/1/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20s.pdf https://eprints.ums.edu.my/id/eprint/25502/2/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20sp.%201.pdf |
| Summary: | Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12 -epi-19-O-methylscalarin (3) and methyl 18- hydroxy- 19-norscalar-16 -en-20- carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12α-OAc and 12β-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), S1T cells. This is the first record of scalarane sesterterpenes from the Bornean sponge. |
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