Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp.
Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12 -epi-19-O-methylscalarin (3) and methyl 18- hydroxy- 19-norscalar-16 -en-20- carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12α-OAc and 12β-OAc, and 19-olide and 20-...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/25502/1/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20s.pdf https://eprints.ums.edu.my/id/eprint/25502/2/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20sp.%201.pdf |
| _version_ | 1796910377843294208 |
|---|---|
| author | Phan, Chin Soon Takashi Kamada Toshiyuki Hamada Charles Santhanaraju Vairappan |
| author_facet | Phan, Chin Soon Takashi Kamada Toshiyuki Hamada Charles Santhanaraju Vairappan |
| author_sort | Phan, Chin Soon |
| collection | UMS |
| description | Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12 -epi-19-O-methylscalarin (3) and methyl 18- hydroxy- 19-norscalar-16 -en-20- carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12α-OAc and 12β-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), S1T cells. This is the first record of scalarane sesterterpenes from the Bornean sponge. |
| first_indexed | 2024-03-06T03:03:33Z |
| format | Article |
| id | ums.eprints-25502 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:03:33Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ums.eprints-255022020-06-10T07:29:51Z https://eprints.ums.edu.my/id/eprint/25502/ Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. Phan, Chin Soon Takashi Kamada Toshiyuki Hamada Charles Santhanaraju Vairappan QH Natural history QH301-705.5 Biology (General) Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12 -epi-19-O-methylscalarin (3) and methyl 18- hydroxy- 19-norscalar-16 -en-20- carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12α-OAc and 12β-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), S1T cells. This is the first record of scalarane sesterterpenes from the Bornean sponge. 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25502/1/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20s.pdf text en https://eprints.ums.edu.my/id/eprint/25502/2/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20sp.%201.pdf Phan, Chin Soon and Takashi Kamada and Toshiyuki Hamada and Charles Santhanaraju Vairappan (2018) Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. Records of Natural Products, 12 (6). pp. 643-647. |
| spellingShingle | QH Natural history QH301-705.5 Biology (General) Phan, Chin Soon Takashi Kamada Toshiyuki Hamada Charles Santhanaraju Vairappan Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. |
| title | Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. |
| title_full | Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. |
| title_fullStr | Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. |
| title_full_unstemmed | Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. |
| title_short | Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. |
| title_sort | cytotoxic sesterterpenoids from bornean sponge spongia sp |
| topic | QH Natural history QH301-705.5 Biology (General) |
| url | https://eprints.ums.edu.my/id/eprint/25502/1/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20s.pdf https://eprints.ums.edu.my/id/eprint/25502/2/Cytotoxic%20Sesterterpenoids%20from%20Bornean%20Sponge%20Spongia%20sp.%201.pdf |
| work_keys_str_mv | AT phanchinsoon cytotoxicsesterterpenoidsfromborneanspongespongiasp AT takashikamada cytotoxicsesterterpenoidsfromborneanspongespongiasp AT toshiyukihamada cytotoxicsesterterpenoidsfromborneanspongespongiasp AT charlessanthanarajuvairappan cytotoxicsesterterpenoidsfromborneanspongespongiasp |