Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata
The red alga Chondria armata is known to produce and contain a rich diversity of secondary metabolites, such as domoic acid-related alkaloids and triterpene polyethers. Our investigation on red alga C. armata from Kagoshima coast, Japan, resulted in the isolation of two new triterpene polyethers, ba...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/25981/1/Two%20cytotoxic%20squalene-derived%20polyethers%20from%20the%20Japanese%20red%20alga%20Chondria%20armata.pdf |
| _version_ | 1825713955204497408 |
|---|---|
| author | Toshiyuki Hamada Kazushi Kobayashi Naomichi Arima Fumito Tani Charles Santhanaraju Vairappan Satoaki Onitsuka Hiroaki Okamura |
| author_facet | Toshiyuki Hamada Kazushi Kobayashi Naomichi Arima Fumito Tani Charles Santhanaraju Vairappan Satoaki Onitsuka Hiroaki Okamura |
| author_sort | Toshiyuki Hamada |
| collection | UMS |
| description | The red alga Chondria armata is known to produce and contain a rich diversity of secondary metabolites, such as domoic acid-related alkaloids and triterpene polyethers. Our investigation on red alga C. armata from Kagoshima coast, Japan, resulted in the isolation of two new triterpene polyethers, bandokorols A (1) and B (2). The structures of these compounds were determined based on spectroscopic data such as infrared (FTIR), 1H-NMR, APT, 1H–1H-COSY, HSQC, HMBC, NOESY and FAB mass spectrometry (HRFABMS). The anticancer potentials of these compounds were tested against adult T-cell leukaemia (ATL), S1T cells and their IC50 values are reported here. |
| first_indexed | 2024-03-06T03:04:35Z |
| format | Article |
| id | ums.eprints-25981 |
| institution | Universiti Malaysia Sabah |
| language | English |
| last_indexed | 2024-03-06T03:04:35Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ums.eprints-259812020-09-21T00:24:15Z https://eprints.ums.edu.my/id/eprint/25981/ Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata Toshiyuki Hamada Kazushi Kobayashi Naomichi Arima Fumito Tani Charles Santhanaraju Vairappan Satoaki Onitsuka Hiroaki Okamura Q Science (General) The red alga Chondria armata is known to produce and contain a rich diversity of secondary metabolites, such as domoic acid-related alkaloids and triterpene polyethers. Our investigation on red alga C. armata from Kagoshima coast, Japan, resulted in the isolation of two new triterpene polyethers, bandokorols A (1) and B (2). The structures of these compounds were determined based on spectroscopic data such as infrared (FTIR), 1H-NMR, APT, 1H–1H-COSY, HSQC, HMBC, NOESY and FAB mass spectrometry (HRFABMS). The anticancer potentials of these compounds were tested against adult T-cell leukaemia (ATL), S1T cells and their IC50 values are reported here. 2020 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25981/1/Two%20cytotoxic%20squalene-derived%20polyethers%20from%20the%20Japanese%20red%20alga%20Chondria%20armata.pdf Toshiyuki Hamada and Kazushi Kobayashi and Naomichi Arima and Fumito Tani and Charles Santhanaraju Vairappan and Satoaki Onitsuka and Hiroaki Okamura (2020) Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata. Natural Product Research. https://doi.org/10.1080/14786419.2020.1777411 |
| spellingShingle | Q Science (General) Toshiyuki Hamada Kazushi Kobayashi Naomichi Arima Fumito Tani Charles Santhanaraju Vairappan Satoaki Onitsuka Hiroaki Okamura Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata |
| title | Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata |
| title_full | Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata |
| title_fullStr | Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata |
| title_full_unstemmed | Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata |
| title_short | Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata |
| title_sort | two cytotoxic squalene derived polyethers from the japanese red alga chondria armata |
| topic | Q Science (General) |
| url | https://eprints.ums.edu.my/id/eprint/25981/1/Two%20cytotoxic%20squalene-derived%20polyethers%20from%20the%20Japanese%20red%20alga%20Chondria%20armata.pdf |
| work_keys_str_mv | AT toshiyukihamada twocytotoxicsqualenederivedpolyethersfromthejapaneseredalgachondriaarmata AT kazushikobayashi twocytotoxicsqualenederivedpolyethersfromthejapaneseredalgachondriaarmata AT naomichiarima twocytotoxicsqualenederivedpolyethersfromthejapaneseredalgachondriaarmata AT fumitotani twocytotoxicsqualenederivedpolyethersfromthejapaneseredalgachondriaarmata AT charlessanthanarajuvairappan twocytotoxicsqualenederivedpolyethersfromthejapaneseredalgachondriaarmata AT satoakionitsuka twocytotoxicsqualenederivedpolyethersfromthejapaneseredalgachondriaarmata AT hiroakiokamura twocytotoxicsqualenederivedpolyethersfromthejapaneseredalgachondriaarmata |