Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma

Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the g...

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Detalles Bibliográficos
Autores principales: Syamim Johan, Allim Khairuddin, Asyraf Mohd Zuki, Wei Woon Teng, Firdaus Hayati, Aung Mra, Nornazirah Azizan
Formato: Artículo
Lenguaje:English
English
Publicado: Springer Nature 2021
Materias:
Acceso en línea:https://eprints.ums.edu.my/id/eprint/26723/1/Abstract-Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf
https://eprints.ums.edu.my/id/eprint/26723/2/Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf
Descripción
Sumario:Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the gastrointestinal (GI) tract, lymph nodes, and skin. We experience a 74-year-old male who presented with abdominal discomfort, altered bowel habit, loss of weight, and loss of appetite with a palpable abdominal mass. Upper endoscopy revealed multiple dish-like and raised nodular mass with a central ulcer in the stomach and duodenum. The histology was consistent with high-grade lymphoma of the plasmablastic type. The immunohistochemistry was positive for plasma cells marker of CD38 and CD138, but negative for the lymphocytic marker of CD45, as well as mature T and B cell marker of CD3 and CD20. Unfortunately, the patient succumbed due to sepsis without completion of his investigations and treatments.