Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma
Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the g...
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English English |
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Springer Nature
2021
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| Нөхцлүүд: | |
| Онлайн хандалт: | https://eprints.ums.edu.my/id/eprint/26723/1/Abstract-Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf https://eprints.ums.edu.my/id/eprint/26723/2/Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf |
| _version_ | 1825714043792392192 |
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| author | Syamim Johan Allim Khairuddin Asyraf Mohd Zuki Wei Woon Teng Firdaus Hayati Aung Mra Nornazirah Azizan |
| author_facet | Syamim Johan Allim Khairuddin Asyraf Mohd Zuki Wei Woon Teng Firdaus Hayati Aung Mra Nornazirah Azizan |
| author_sort | Syamim Johan |
| collection | UMS |
| description | Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the gastrointestinal (GI) tract, lymph nodes, and skin. We experience a 74-year-old male who presented with abdominal discomfort, altered bowel habit, loss of weight, and loss of appetite with a palpable abdominal mass. Upper endoscopy revealed multiple dish-like and raised nodular mass with a central ulcer in the stomach and duodenum. The histology was consistent with high-grade lymphoma of the plasmablastic type. The immunohistochemistry was positive for plasma cells marker of CD38 and CD138, but negative for the lymphocytic marker of CD45, as well as mature T and B cell marker of CD3 and CD20. Unfortunately, the patient succumbed due to sepsis without completion of his investigations and treatments. |
| first_indexed | 2024-03-06T03:05:56Z |
| format | Article |
| id | ums.eprints-26723 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:05:56Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | ums.eprints-267232021-04-12T02:53:41Z https://eprints.ums.edu.my/id/eprint/26723/ Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma Syamim Johan Allim Khairuddin Asyraf Mohd Zuki Wei Woon Teng Firdaus Hayati Aung Mra Nornazirah Azizan R Medicine (General) Plasmablastic lymphoma (PBL) is an uncommon human immunodeficiency virus (HIV)-associated lymphoma, with a predilection to develop in the oral cavity. It usually has a plasmablastic morphology with weak or no expression of B cell-associated markers. Among non-HIV patients, it tends to occur in the gastrointestinal (GI) tract, lymph nodes, and skin. We experience a 74-year-old male who presented with abdominal discomfort, altered bowel habit, loss of weight, and loss of appetite with a palpable abdominal mass. Upper endoscopy revealed multiple dish-like and raised nodular mass with a central ulcer in the stomach and duodenum. The histology was consistent with high-grade lymphoma of the plasmablastic type. The immunohistochemistry was positive for plasma cells marker of CD38 and CD138, but negative for the lymphocytic marker of CD45, as well as mature T and B cell marker of CD3 and CD20. Unfortunately, the patient succumbed due to sepsis without completion of his investigations and treatments. Springer Nature 2021-04-01 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/26723/1/Abstract-Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf text en https://eprints.ums.edu.my/id/eprint/26723/2/Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf Syamim Johan and Allim Khairuddin and Asyraf Mohd Zuki and Wei Woon Teng and Firdaus Hayati and Aung Mra and Nornazirah Azizan (2021) Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma. Clinical Journal of Gastroenterology. https://doi.org/10.1007/s12328-021-01409-3 |
| spellingShingle | R Medicine (General) Syamim Johan Allim Khairuddin Asyraf Mohd Zuki Wei Woon Teng Firdaus Hayati Aung Mra Nornazirah Azizan Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma |
| title | Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma |
| title_full | Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma |
| title_fullStr | Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma |
| title_full_unstemmed | Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma |
| title_short | Malignant ulcer: a great mimicker of gastric plasmablastic lymphoma |
| title_sort | malignant ulcer a great mimicker of gastric plasmablastic lymphoma |
| topic | R Medicine (General) |
| url | https://eprints.ums.edu.my/id/eprint/26723/1/Abstract-Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf https://eprints.ums.edu.my/id/eprint/26723/2/Malignant%20ulcer%2C%20a%20great%20mimicker%20of%20gastric%20plasmablastic%20lymphoma.pdf |
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