Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction
Aims: Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. Main methods: Male Sprague-Dawle...
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| Format: | Article |
| Language: | English English |
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Elsevier Inc.
2017
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| Online Access: | https://eprints.ums.edu.my/id/eprint/27426/1/Roselle%20is%20cardioprotective%20in%20diet-induced%20obesity%20rat%20model%20with%20myocardial%20infarction%20FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/27426/2/Roselle%20is%20cardioprotective%20in%20diet-induced%20obesity%20rat%20model%20with%20myocardial%20infarction%20ABSTRACT.pdf |
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| author | Yiang-Nee, Lislivia Sia Siti Aishah Mohd Ali Jalifah Latip Norsyahida Mohd Fauzi |
| author_facet | Yiang-Nee, Lislivia Sia Siti Aishah Mohd Ali Jalifah Latip Norsyahida Mohd Fauzi |
| author_sort | Yiang-Nee, Lislivia Sia |
| collection | UMS |
| description | Aims: Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. Main methods: Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8 weeks. Firstly, OB rats were divided into (1) OB and (2) OB+ R (100 mg/kg, p.o, 28 days). Then, OB rats were subjected to MI (ISO, 85 mg/kg, s.c, 2 days) and divided into three groups: (1) OB +MI, (2) OB +MI+R and (3) OB +MI + enalapril for another 4 weeks. Key findings: Roselle ameliorated OB and OB +MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB +MI groups were all attenuated by roselle. Significance: These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB + MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future. |
| first_indexed | 2024-03-06T03:07:36Z |
| format | Article |
| id | ums.eprints-27426 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:07:36Z |
| publishDate | 2017 |
| publisher | Elsevier Inc. |
| record_format | dspace |
| spelling | ums.eprints-274262021-06-26T00:56:05Z https://eprints.ums.edu.my/id/eprint/27426/ Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction Yiang-Nee, Lislivia Sia Siti Aishah Mohd Ali Jalifah Latip Norsyahida Mohd Fauzi QK Botany R Medicine (General) TX341-641 Nutrition. Foods and food supply Aims: Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. Main methods: Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8 weeks. Firstly, OB rats were divided into (1) OB and (2) OB+ R (100 mg/kg, p.o, 28 days). Then, OB rats were subjected to MI (ISO, 85 mg/kg, s.c, 2 days) and divided into three groups: (1) OB +MI, (2) OB +MI+R and (3) OB +MI + enalapril for another 4 weeks. Key findings: Roselle ameliorated OB and OB +MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB +MI groups were all attenuated by roselle. Significance: These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB + MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future. Elsevier Inc. 2017 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/27426/1/Roselle%20is%20cardioprotective%20in%20diet-induced%20obesity%20rat%20model%20with%20myocardial%20infarction%20FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/27426/2/Roselle%20is%20cardioprotective%20in%20diet-induced%20obesity%20rat%20model%20with%20myocardial%20infarction%20ABSTRACT.pdf Yiang-Nee, Lislivia Sia and Siti Aishah Mohd Ali and Jalifah Latip and Norsyahida Mohd Fauzi (2017) Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction. Life Sciences, 191 (1). pp. 157-165. ISSN 0024-3205 https://www.sciencedirect.com/science/article/abs/pii/S0024320517305441?via%3Dihub |
| spellingShingle | QK Botany R Medicine (General) TX341-641 Nutrition. Foods and food supply Yiang-Nee, Lislivia Sia Siti Aishah Mohd Ali Jalifah Latip Norsyahida Mohd Fauzi Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction |
| title | Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction |
| title_full | Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction |
| title_fullStr | Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction |
| title_full_unstemmed | Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction |
| title_short | Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction |
| title_sort | roselle is cardioprotective in diet induced obesity rat model with myocardial infarction |
| topic | QK Botany R Medicine (General) TX341-641 Nutrition. Foods and food supply |
| url | https://eprints.ums.edu.my/id/eprint/27426/1/Roselle%20is%20cardioprotective%20in%20diet-induced%20obesity%20rat%20model%20with%20myocardial%20infarction%20FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/27426/2/Roselle%20is%20cardioprotective%20in%20diet-induced%20obesity%20rat%20model%20with%20myocardial%20infarction%20ABSTRACT.pdf |
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