Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri
Acetylcholinester ase (AChE) generally known to be sensitive toward insecticides but its sensitivity toward heavy metals was least reported. Herein, a sensitive assay for heavy metals has been pursued using AChE in a rapid and economic manner. The AChE from a mudskipper, Periophthalmodon schlosseri...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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2015
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| Online Access: | https://eprints.ums.edu.my/id/eprint/27449/1/Heavy%20metals%20biomonitoring%20via%20inhibitive%20assay%20of%20acetylcholinesterase%20from%20Periophthalmodon%20schlosseri%20ABSTRACT.pdf |
| _version_ | 1825714159981953024 |
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| author | Mohd Khalizan Sabullah Mohd Rosni Sulaiman Mohd Shukri Shukor Mohd Termizi Yusof Wan Lutfi Wan Johari Mohd Yunus Shukor Amir Syahir |
| author_facet | Mohd Khalizan Sabullah Mohd Rosni Sulaiman Mohd Shukri Shukor Mohd Termizi Yusof Wan Lutfi Wan Johari Mohd Yunus Shukor Amir Syahir |
| author_sort | Mohd Khalizan Sabullah |
| collection | UMS |
| description | Acetylcholinester ase (AChE) generally known to be sensitive toward insecticides but its sensitivity toward heavy metals was least reported. Herein, a sensitive assay for heavy metals has been pursued using AChE in a rapid and economic manner. The AChE from a mudskipper, Periophthalmodon schlosseri has been found to be sensitive toward copper > mercury > chromium > and arsenic ions at the sub parts per million levels. Field trial works showed that the assay was applicable in detecting heavy metals pollution from effluents of industrial sites at near real time and verified using ICP-OES and Flow Injection Mercury System (FIMS 400). Furthermore, hierarchical cluster analyses of inhibition profiles were performed, revealing a comparable capability of the AChE compared to the gold standard of Microtox™ method. |
| first_indexed | 2024-03-06T03:07:40Z |
| format | Article |
| id | ums.eprints-27449 |
| institution | Universiti Malaysia Sabah |
| language | English |
| last_indexed | 2024-03-06T03:07:40Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ums.eprints-274492021-06-26T01:43:52Z https://eprints.ums.edu.my/id/eprint/27449/ Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri Mohd Khalizan Sabullah Mohd Rosni Sulaiman Mohd Shukri Shukor Mohd Termizi Yusof Wan Lutfi Wan Johari Mohd Yunus Shukor Amir Syahir QD Chemistry TN Mining engineering. Metallurgy Acetylcholinester ase (AChE) generally known to be sensitive toward insecticides but its sensitivity toward heavy metals was least reported. Herein, a sensitive assay for heavy metals has been pursued using AChE in a rapid and economic manner. The AChE from a mudskipper, Periophthalmodon schlosseri has been found to be sensitive toward copper > mercury > chromium > and arsenic ions at the sub parts per million levels. Field trial works showed that the assay was applicable in detecting heavy metals pollution from effluents of industrial sites at near real time and verified using ICP-OES and Flow Injection Mercury System (FIMS 400). Furthermore, hierarchical cluster analyses of inhibition profiles were performed, revealing a comparable capability of the AChE compared to the gold standard of Microtox™ method. 2015 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/27449/1/Heavy%20metals%20biomonitoring%20via%20inhibitive%20assay%20of%20acetylcholinesterase%20from%20Periophthalmodon%20schlosseri%20ABSTRACT.pdf Mohd Khalizan Sabullah and Mohd Rosni Sulaiman and Mohd Shukri Shukor and Mohd Termizi Yusof and Wan Lutfi Wan Johari and Mohd Yunus Shukor and Amir Syahir (2015) Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri. Rendiconti Lincei, 26 (2). pp. 151-158. ISSN 1720-0776 https://link.springer.com/article/10.1007%2Fs12210-014-0359-0 |
| spellingShingle | QD Chemistry TN Mining engineering. Metallurgy Mohd Khalizan Sabullah Mohd Rosni Sulaiman Mohd Shukri Shukor Mohd Termizi Yusof Wan Lutfi Wan Johari Mohd Yunus Shukor Amir Syahir Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri |
| title | Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri |
| title_full | Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri |
| title_fullStr | Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri |
| title_full_unstemmed | Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri |
| title_short | Heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from Periophthalmodon schlosseri |
| title_sort | heavy metals biomonitoring via inhibitive assay of acetylcholinesterase from periophthalmodon schlosseri |
| topic | QD Chemistry TN Mining engineering. Metallurgy |
| url | https://eprints.ums.edu.my/id/eprint/27449/1/Heavy%20metals%20biomonitoring%20via%20inhibitive%20assay%20of%20acetylcholinesterase%20from%20Periophthalmodon%20schlosseri%20ABSTRACT.pdf |
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