Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
Caffeic acid (CA) has been present in many herbs, vegetables, and fruits. CA is a bioactive compound and exhibits various health advantages that are linked with its anti-oxidant functions and implicated in the therapy and prevention of disease progression of inflammatory diseases and cancer. The ant...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Frontiers Media S.A.
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/29155/1/Potential%20Therapeutic%20Implications%20of%20Caffeic%20Acid%20in%20Cancer%20Signaling_%20Past%2C%20Present%2C%20and%20Future.pdf https://eprints.ums.edu.my/id/eprint/29155/2/Potential%20Therapeutic%20Implications%20of%20Caffeic%20Acid%20in%20Cancer%20Signaling_%20Past%2C%20Present%2C%20and%20Future%20%20_ABSTRACT.pdf |
| _version_ | 1796910736153247744 |
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| author | Manzar Alam Ghulam Md Ashraf Kayenat Sheikh Anish Khan Sabeeha Ali Md. Meraj Ansari Mohd Adnan Pasupuleti Visweswara Rao Md. Imtaiyaz Hassan |
| author_facet | Manzar Alam Ghulam Md Ashraf Kayenat Sheikh Anish Khan Sabeeha Ali Md. Meraj Ansari Mohd Adnan Pasupuleti Visweswara Rao Md. Imtaiyaz Hassan |
| author_sort | Manzar Alam |
| collection | UMS |
| description | Caffeic acid (CA) has been present in many herbs, vegetables, and fruits. CA is a bioactive compound and exhibits various health advantages that are linked with its anti-oxidant functions and implicated in the therapy and prevention of disease progression of inflammatory diseases and cancer. The anti-tumor action of CA is attributed to its prooxidant and anti-oxidant properties. CA’s mechanism of action involves preventing reactive oxygen species formation, diminishing the angiogenesis of cancer cells, enhancing the tumor cells’ DNA oxidation, and repressing MMP-2 and MMP-9. CA and its derivatives have been reported to exhibit anti-carcinogenic properties against many cancer types. CA has indicated low intestinal absorption, low oral bioavailability in rats, and pitiable permeability across Caco-2 cells. In the present review, we have illustrated CA’s therapeutic potential, pharmacokinetics, and characteristics. The pharmacological effects of CA, the emphasis on in vitro and in vivo studies, and the existing challenges and prospects of CA for cancer treatment and prevention are discussed in this review. |
| first_indexed | 2024-03-06T03:08:41Z |
| format | Article |
| id | ums.eprints-29155 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:08:41Z |
| publishDate | 2022 |
| publisher | Frontiers Media S.A. |
| record_format | dspace |
| spelling | ums.eprints-291552022-08-01T00:34:42Z https://eprints.ums.edu.my/id/eprint/29155/ Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future Manzar Alam Ghulam Md Ashraf Kayenat Sheikh Anish Khan Sabeeha Ali Md. Meraj Ansari Mohd Adnan Pasupuleti Visweswara Rao Md. Imtaiyaz Hassan RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Caffeic acid (CA) has been present in many herbs, vegetables, and fruits. CA is a bioactive compound and exhibits various health advantages that are linked with its anti-oxidant functions and implicated in the therapy and prevention of disease progression of inflammatory diseases and cancer. The anti-tumor action of CA is attributed to its prooxidant and anti-oxidant properties. CA’s mechanism of action involves preventing reactive oxygen species formation, diminishing the angiogenesis of cancer cells, enhancing the tumor cells’ DNA oxidation, and repressing MMP-2 and MMP-9. CA and its derivatives have been reported to exhibit anti-carcinogenic properties against many cancer types. CA has indicated low intestinal absorption, low oral bioavailability in rats, and pitiable permeability across Caco-2 cells. In the present review, we have illustrated CA’s therapeutic potential, pharmacokinetics, and characteristics. The pharmacological effects of CA, the emphasis on in vitro and in vivo studies, and the existing challenges and prospects of CA for cancer treatment and prevention are discussed in this review. Frontiers Media S.A. 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/29155/1/Potential%20Therapeutic%20Implications%20of%20Caffeic%20Acid%20in%20Cancer%20Signaling_%20Past%2C%20Present%2C%20and%20Future.pdf text en https://eprints.ums.edu.my/id/eprint/29155/2/Potential%20Therapeutic%20Implications%20of%20Caffeic%20Acid%20in%20Cancer%20Signaling_%20Past%2C%20Present%2C%20and%20Future%20%20_ABSTRACT.pdf Manzar Alam and Ghulam Md Ashraf and Kayenat Sheikh and Anish Khan and Sabeeha Ali and Md. Meraj Ansari and Mohd Adnan and Pasupuleti Visweswara Rao and Md. Imtaiyaz Hassan (2022) Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future. Frontiers in Pharmacology, 13 (.84587). pp. 1-14. ISSN 1666-9812 https://www.frontiersin.org/articles/10.3389/fphar.2022.845871/full https://doi.org/10.3389/fphar.2022.845871 https://doi.org/10.3389/fphar.2022.845871 |
| spellingShingle | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Manzar Alam Ghulam Md Ashraf Kayenat Sheikh Anish Khan Sabeeha Ali Md. Meraj Ansari Mohd Adnan Pasupuleti Visweswara Rao Md. Imtaiyaz Hassan Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future |
| title | Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future |
| title_full | Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future |
| title_fullStr | Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future |
| title_full_unstemmed | Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future |
| title_short | Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future |
| title_sort | potential therapeutic implications of caffeic acid in cancer signaling past present and future |
| topic | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| url | https://eprints.ums.edu.my/id/eprint/29155/1/Potential%20Therapeutic%20Implications%20of%20Caffeic%20Acid%20in%20Cancer%20Signaling_%20Past%2C%20Present%2C%20and%20Future.pdf https://eprints.ums.edu.my/id/eprint/29155/2/Potential%20Therapeutic%20Implications%20of%20Caffeic%20Acid%20in%20Cancer%20Signaling_%20Past%2C%20Present%2C%20and%20Future%20%20_ABSTRACT.pdf |
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