High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo
Leptospirosis is a public health challenge in Sabah State of Malaysian Borneo. Rapid urbanization, rural-to-urban migration, and undocumented immigration in Sabah have increased the pressure on the urban garbage disposal system. Rodents and other small animals thrive under these conditions. We hypot...
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| Format: | Article |
| Language: | English English |
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Nature Research
2020
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| Online Access: | https://eprints.ums.edu.my/id/eprint/29961/1/High%20incidence%20of%20asymptomatic%20leptospirosis%20among%20urban%20sanitation%20workers%20from%20Kota%20Kinabalu%2C%20Sabah%2C%20Malaysian%20Borneo.pdf https://eprints.ums.edu.my/id/eprint/29961/2/High%20incidence%20of%20asymptomatic%20leptospirosis%20among%20urban%20sanitation%20workers%20from%20Kota%20Kinabalu%2C%20Sabah%2C%20Malaysian%20Borneo1.pdf |
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| author | Mohammad Saffree Jeffree Daisuke Mori Nur Athirah Yusof Azman Atil Khamisah Awang Lukman Rafdah Othman Mohd Rohaizat Hassan Lela Suut KamruddinAhmed |
| author_facet | Mohammad Saffree Jeffree Daisuke Mori Nur Athirah Yusof Azman Atil Khamisah Awang Lukman Rafdah Othman Mohd Rohaizat Hassan Lela Suut KamruddinAhmed |
| author_sort | Mohammad Saffree Jeffree |
| collection | UMS |
| description | Leptospirosis is a public health challenge in Sabah State of Malaysian Borneo. Rapid urbanization, rural-to-urban migration, and undocumented immigration in Sabah have increased the pressure on the urban garbage disposal system. Rodents and other small animals thrive under these conditions. We hypothesized that urban sanitation workers would be at risk of developing leptospirosis. In total, 303 urban sanitation workers with a mean age of 42.6 years were enrolled in this study. The serum samples collected from these workers were subjected to the microscopic agglutination test (MAT), PCR and nucleotide sequencing of the amplicons to confirm the presence of Leptospira. The phylogenetic analysis using the neighbor joining method was performed to assess whether they were pathogenic. In this study 43.8% (133/303) of the samples were MAT-seropositive and among them, 29 (21.8%) were positive by PCR. Nucleotide sequencing of the amplicons confirmed the presence of Leptospira. Phylogenetic analysis showed that our strains belonged to the pathogenic group of Leptospira. A high proportion of urban sanitation workers were seropositive for leptospirosis, and a considerable number were PCR positive for Leptospira, thereby indicating asymptomatic infections. Further research is needed to confirm whether this is a transient phenomenon or antibiotic therapy is required |
| first_indexed | 2024-03-06T03:09:20Z |
| format | Article |
| id | ums.eprints-29961 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:09:20Z |
| publishDate | 2020 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | ums.eprints-299612021-07-14T01:00:26Z https://eprints.ums.edu.my/id/eprint/29961/ High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo Mohammad Saffree Jeffree Daisuke Mori Nur Athirah Yusof Azman Atil Khamisah Awang Lukman Rafdah Othman Mohd Rohaizat Hassan Lela Suut KamruddinAhmed R Medicine (General) Leptospirosis is a public health challenge in Sabah State of Malaysian Borneo. Rapid urbanization, rural-to-urban migration, and undocumented immigration in Sabah have increased the pressure on the urban garbage disposal system. Rodents and other small animals thrive under these conditions. We hypothesized that urban sanitation workers would be at risk of developing leptospirosis. In total, 303 urban sanitation workers with a mean age of 42.6 years were enrolled in this study. The serum samples collected from these workers were subjected to the microscopic agglutination test (MAT), PCR and nucleotide sequencing of the amplicons to confirm the presence of Leptospira. The phylogenetic analysis using the neighbor joining method was performed to assess whether they were pathogenic. In this study 43.8% (133/303) of the samples were MAT-seropositive and among them, 29 (21.8%) were positive by PCR. Nucleotide sequencing of the amplicons confirmed the presence of Leptospira. Phylogenetic analysis showed that our strains belonged to the pathogenic group of Leptospira. A high proportion of urban sanitation workers were seropositive for leptospirosis, and a considerable number were PCR positive for Leptospira, thereby indicating asymptomatic infections. Further research is needed to confirm whether this is a transient phenomenon or antibiotic therapy is required Nature Research 2020 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/29961/1/High%20incidence%20of%20asymptomatic%20leptospirosis%20among%20urban%20sanitation%20workers%20from%20Kota%20Kinabalu%2C%20Sabah%2C%20Malaysian%20Borneo.pdf text en https://eprints.ums.edu.my/id/eprint/29961/2/High%20incidence%20of%20asymptomatic%20leptospirosis%20among%20urban%20sanitation%20workers%20from%20Kota%20Kinabalu%2C%20Sabah%2C%20Malaysian%20Borneo1.pdf Mohammad Saffree Jeffree and Daisuke Mori and Nur Athirah Yusof and Azman Atil and Khamisah Awang Lukman and Rafdah Othman and Mohd Rohaizat Hassan and Lela Suut and KamruddinAhmed (2020) High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo. Scientific Reports, 10 (19442). pp. 1-8. ISSN 2045-2322 https://www.nature.com/articles/s41598-020-76595-0.pdf https://doi.org/10.1038/s41598-020-76595-0 https://doi.org/10.1038/s41598-020-76595-0 |
| spellingShingle | R Medicine (General) Mohammad Saffree Jeffree Daisuke Mori Nur Athirah Yusof Azman Atil Khamisah Awang Lukman Rafdah Othman Mohd Rohaizat Hassan Lela Suut KamruddinAhmed High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo |
| title | High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo |
| title_full | High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo |
| title_fullStr | High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo |
| title_full_unstemmed | High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo |
| title_short | High incidence of asymptomatic leptospirosis among urban sanitation workers from Kota Kinabalu, Sabah, Malaysian Borneo |
| title_sort | high incidence of asymptomatic leptospirosis among urban sanitation workers from kota kinabalu sabah malaysian borneo |
| topic | R Medicine (General) |
| url | https://eprints.ums.edu.my/id/eprint/29961/1/High%20incidence%20of%20asymptomatic%20leptospirosis%20among%20urban%20sanitation%20workers%20from%20Kota%20Kinabalu%2C%20Sabah%2C%20Malaysian%20Borneo.pdf https://eprints.ums.edu.my/id/eprint/29961/2/High%20incidence%20of%20asymptomatic%20leptospirosis%20among%20urban%20sanitation%20workers%20from%20Kota%20Kinabalu%2C%20Sabah%2C%20Malaysian%20Borneo1.pdf |
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