Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
Stroke is the second‑leading cause of global mortality and the third leading cause of disability. Numerous in-dependent studies have reported that genetic mutations such as single nucleotide polymorphisms (SNPs) within genes may alter an individual’s susceptibility towards several health disorders t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
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Elsevier B.V.
2021
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| Online Access: | https://eprints.ums.edu.my/id/eprint/30110/1/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/30110/2/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20ABSTRACT.pdf |
| _version_ | 1825714297230065664 |
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| author | Kok Yeow Phneh Chong, Eric Tzyy Jiann Lee, Ping Chin |
| author_facet | Kok Yeow Phneh Chong, Eric Tzyy Jiann Lee, Ping Chin |
| author_sort | Kok Yeow Phneh |
| collection | UMS |
| description | Stroke is the second‑leading cause of global mortality and the third leading cause of disability. Numerous in-dependent studies have reported that genetic mutations such as single nucleotide polymorphisms (SNPs) within genes may alter an individual’s susceptibility towards several health disorders that subsequently lead to the development of stroke incidence. To date, constructive information that summarizes this particular relationship is limited. Hence, this comprehensive review focuses on the role of SNPs in facilitating susceptibility to several health disorders including brain aneurysms, atrial fibrillation, atherosclerosis, and hyperlipidemia, and their association with the development of higher stroke incidence. We discussed a total of 33 SNPs in this review that includes 11 SNPs associated with brain aneurysms, 4 SNPs associated with atrial fibrillation, 13 SNPs associated with atherosclerosis, and 5 SNPs associated with hyperlipidemia. The SNPs data could assist in determining an individual’s risk of different health disorders and subsequently stroke. Therefore, pharmacogenomics could be applied to effectively provide appropriate personalized medications and genetic counseling. |
| first_indexed | 2024-03-06T03:09:42Z |
| format | Article |
| id | ums.eprints-30110 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:09:42Z |
| publishDate | 2021 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | ums.eprints-301102021-07-28T02:37:16Z https://eprints.ums.edu.my/id/eprint/30110/ Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review Kok Yeow Phneh Chong, Eric Tzyy Jiann Lee, Ping Chin TP Chemical technology Stroke is the second‑leading cause of global mortality and the third leading cause of disability. Numerous in-dependent studies have reported that genetic mutations such as single nucleotide polymorphisms (SNPs) within genes may alter an individual’s susceptibility towards several health disorders that subsequently lead to the development of stroke incidence. To date, constructive information that summarizes this particular relationship is limited. Hence, this comprehensive review focuses on the role of SNPs in facilitating susceptibility to several health disorders including brain aneurysms, atrial fibrillation, atherosclerosis, and hyperlipidemia, and their association with the development of higher stroke incidence. We discussed a total of 33 SNPs in this review that includes 11 SNPs associated with brain aneurysms, 4 SNPs associated with atrial fibrillation, 13 SNPs associated with atherosclerosis, and 5 SNPs associated with hyperlipidemia. The SNPs data could assist in determining an individual’s risk of different health disorders and subsequently stroke. Therefore, pharmacogenomics could be applied to effectively provide appropriate personalized medications and genetic counseling. Elsevier B.V. 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/30110/1/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/30110/2/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20ABSTRACT.pdf Kok Yeow Phneh and Chong, Eric Tzyy Jiann and Lee, Ping Chin (2021) Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review. Meta Gene, 28. pp. 1-8. ISSN 2214-5400 (E-ISSN) https://www.sciencedirect.com/science/article/pii/S221454002100030X?casa_token=RPsboh54_rYAAAAA:dkYW6i-OUU5jzEjBxKKG8_HVB7JYG3ax6GPbRpBtbpERW7Vo1IHAFSOscrHtm1NMLbt8fFNSuE5- https://doi.org/10.1016/j.mgene.2021.100879 https://doi.org/10.1016/j.mgene.2021.100879 |
| spellingShingle | TP Chemical technology Kok Yeow Phneh Chong, Eric Tzyy Jiann Lee, Ping Chin Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review |
| title | Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review |
| title_full | Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review |
| title_fullStr | Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review |
| title_full_unstemmed | Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review |
| title_short | Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review |
| title_sort | role of single nucleotide polymorphisms in susceptibility of stroke a systemic review |
| topic | TP Chemical technology |
| url | https://eprints.ums.edu.my/id/eprint/30110/1/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/30110/2/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20ABSTRACT.pdf |
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