Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma
Purpose: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. Materials and Methods: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January 2011 to June 2015 in 100 patients. Immunohistochemical staining of ER-beta and K...
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Korean Urological Association
2018
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Online Access: | https://eprints.ums.edu.my/id/eprint/30583/1/Role%20of%20co-expression%20of%20estrogen%20receptor%20beta%20and%20Ki67%20in%20prostate%20adenocarcinoma%20FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/30583/3/Role%20of%20co-expression%20of%20estrogen%20receptor%20beta%20and%20Ki67%20in%20prostate%20adenocarcinoma%20ABSTRACT.pdf |
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author | Nornazirah Azizan Firdaus Hayati Nur Maya Sabrina Tizen Wirda Indah Farouk Noraidah Masir |
author_facet | Nornazirah Azizan Firdaus Hayati Nur Maya Sabrina Tizen Wirda Indah Farouk Noraidah Masir |
author_sort | Nornazirah Azizan |
collection | UMS |
description | Purpose: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. Materials and Methods: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January 2011 to June 2015 in 100 patients. Immunohistochemical staining of ER-beta and Ki67 was analyzed according to Gleason score categorized into prognostic groups of 1 to 5. Double-immunofluorescent staining of ER-beta and Ki67 was performed in a total of 20 cases to study the co-expression and the relationship between these markers within the same tumor. Results: A total of 53 of 101 cases (52.5%) were positive for ER-beta expression. There was a positive correlation whereby a high percentage of ER-beta expression was seen in the higher prognostic groups (groups 4 and 5; p=0.007). High Ki67 expression was observed in the higher prognostic group, whereas low Ki67 or negative expression was found in the lower prognostic group (p<0.001). The majority of cases evaluated with double-immunofluorescent staining (14/20) showed co-expression of ER-beta and Ki67 at the individual cell level. Conclusions: ER-beta and Ki67 are independent tumor markers in high prognostic groups. Hence, co-expression of ER-beta and Ki67 indicates a more aggressive tumor with a poorer prognosis. |
first_indexed | 2024-03-06T03:10:58Z |
format | Article |
id | ums.eprints-30583 |
institution | Universiti Malaysia Sabah |
language | English English |
last_indexed | 2024-03-06T03:10:58Z |
publishDate | 2018 |
publisher | Korean Urological Association |
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spelling | ums.eprints-305832021-10-22T03:29:54Z https://eprints.ums.edu.my/id/eprint/30583/ Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma Nornazirah Azizan Firdaus Hayati Nur Maya Sabrina Tizen Wirda Indah Farouk Noraidah Masir RC870-923 Diseases of the genitourinary system. Urology Purpose: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. Materials and Methods: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January 2011 to June 2015 in 100 patients. Immunohistochemical staining of ER-beta and Ki67 was analyzed according to Gleason score categorized into prognostic groups of 1 to 5. Double-immunofluorescent staining of ER-beta and Ki67 was performed in a total of 20 cases to study the co-expression and the relationship between these markers within the same tumor. Results: A total of 53 of 101 cases (52.5%) were positive for ER-beta expression. There was a positive correlation whereby a high percentage of ER-beta expression was seen in the higher prognostic groups (groups 4 and 5; p=0.007). High Ki67 expression was observed in the higher prognostic group, whereas low Ki67 or negative expression was found in the lower prognostic group (p<0.001). The majority of cases evaluated with double-immunofluorescent staining (14/20) showed co-expression of ER-beta and Ki67 at the individual cell level. Conclusions: ER-beta and Ki67 are independent tumor markers in high prognostic groups. Hence, co-expression of ER-beta and Ki67 indicates a more aggressive tumor with a poorer prognosis. Korean Urological Association 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/30583/1/Role%20of%20co-expression%20of%20estrogen%20receptor%20beta%20and%20Ki67%20in%20prostate%20adenocarcinoma%20FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/30583/3/Role%20of%20co-expression%20of%20estrogen%20receptor%20beta%20and%20Ki67%20in%20prostate%20adenocarcinoma%20ABSTRACT.pdf Nornazirah Azizan and Firdaus Hayati and Nur Maya Sabrina Tizen and Wirda Indah Farouk and Noraidah Masir (2018) Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma. Investigative and Clinical Urology, 59. pp. 232-237. ISSN 2466-0493 (P-ISSN) , 2466-054X (E-ISSN) https://pubmed.ncbi.nlm.nih.gov/29984337/ https://doi.org/10.4111/icu.2018.59.4.232 https://doi.org/10.4111/icu.2018.59.4.232 |
spellingShingle | RC870-923 Diseases of the genitourinary system. Urology Nornazirah Azizan Firdaus Hayati Nur Maya Sabrina Tizen Wirda Indah Farouk Noraidah Masir Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma |
title | Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma |
title_full | Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma |
title_fullStr | Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma |
title_full_unstemmed | Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma |
title_short | Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma |
title_sort | role of co expression of estrogen receptor beta and ki67 in prostate adenocarcinoma |
topic | RC870-923 Diseases of the genitourinary system. Urology |
url | https://eprints.ums.edu.my/id/eprint/30583/1/Role%20of%20co-expression%20of%20estrogen%20receptor%20beta%20and%20Ki67%20in%20prostate%20adenocarcinoma%20FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/30583/3/Role%20of%20co-expression%20of%20estrogen%20receptor%20beta%20and%20Ki67%20in%20prostate%20adenocarcinoma%20ABSTRACT.pdf |
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