A case of potential inborn error of metabolism as a cause of young onset psychosis
Introduction: Young onset psychosis has poor prognosis, and inborn errors of metabolism (IEM) can be easily missed. There is scarce information regarding IEM and young onset psychosis in Malaysia. Case Report: A 15-year-old Malay girl presented at the age of 8 years with a history of intellectual di...
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| Format: | Article |
| Language: | English English |
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Archives of Psychiatry Research
2021
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| Online Access: | https://eprints.ums.edu.my/id/eprint/32621/1/A%20case%20of%20potential%20inborn%20error%20of%20metabolism%20as%20a%20cause%20of%20young%20onset%20psychosis.pdf https://eprints.ums.edu.my/id/eprint/32621/2/A%20case%20of%20potential%20inborn%20error%20of%20metabolism%20as%20a%20cause%20of%20young%20onset%20psychosis%20_ABSTRACT.pdf |
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| author | Mohd Amiruddin Mohd Kassim Pang, Nicholas Tze Ping Muhammad Haniff Abdullah Norharlina Bahar |
| author_facet | Mohd Amiruddin Mohd Kassim Pang, Nicholas Tze Ping Muhammad Haniff Abdullah Norharlina Bahar |
| author_sort | Mohd Amiruddin Mohd Kassim |
| collection | UMS |
| description | Introduction: Young onset psychosis has poor prognosis, and inborn errors of metabolism (IEM) can be easily missed. There is scarce information regarding IEM and young onset psychosis in Malaysia. Case Report: A 15-year-old Malay girl presented at the age of 8 years with a history of intellectual disability and neuro-regression, subsequently developing psychotic and obsessive-compulsive symptoms several years later. Organic workup revealed elevated lactate levels. Urine organic acid chromatogram revealed a moderate peak of lactate however most other investigations were normal. As MRI brain is normal and there are no neurological signs it appears less likely there is an underlying IEM-related aetiology for psychosis. Discussion: Various IEMs can be related to psychosis however the incidence is very low and quality of evidence is poor. Thus, any psychiatric presentation, particularly with suggestive clinical signs, should warrant an organic (including IEM) workup since these causes are potentially reversible with supplementation. |
| first_indexed | 2024-03-06T03:16:05Z |
| format | Article |
| id | ums.eprints-32621 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:16:05Z |
| publishDate | 2021 |
| publisher | Archives of Psychiatry Research |
| record_format | dspace |
| spelling | ums.eprints-326212022-05-19T01:23:07Z https://eprints.ums.edu.my/id/eprint/32621/ A case of potential inborn error of metabolism as a cause of young onset psychosis Mohd Amiruddin Mohd Kassim Pang, Nicholas Tze Ping Muhammad Haniff Abdullah Norharlina Bahar RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry Introduction: Young onset psychosis has poor prognosis, and inborn errors of metabolism (IEM) can be easily missed. There is scarce information regarding IEM and young onset psychosis in Malaysia. Case Report: A 15-year-old Malay girl presented at the age of 8 years with a history of intellectual disability and neuro-regression, subsequently developing psychotic and obsessive-compulsive symptoms several years later. Organic workup revealed elevated lactate levels. Urine organic acid chromatogram revealed a moderate peak of lactate however most other investigations were normal. As MRI brain is normal and there are no neurological signs it appears less likely there is an underlying IEM-related aetiology for psychosis. Discussion: Various IEMs can be related to psychosis however the incidence is very low and quality of evidence is poor. Thus, any psychiatric presentation, particularly with suggestive clinical signs, should warrant an organic (including IEM) workup since these causes are potentially reversible with supplementation. Archives of Psychiatry Research 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32621/1/A%20case%20of%20potential%20inborn%20error%20of%20metabolism%20as%20a%20cause%20of%20young%20onset%20psychosis.pdf text en https://eprints.ums.edu.my/id/eprint/32621/2/A%20case%20of%20potential%20inborn%20error%20of%20metabolism%20as%20a%20cause%20of%20young%20onset%20psychosis%20_ABSTRACT.pdf Mohd Amiruddin Mohd Kassim and Pang, Nicholas Tze Ping and Muhammad Haniff Abdullah and Norharlina Bahar (2021) A case of potential inborn error of metabolism as a cause of young onset psychosis. Archives of Psychiatry Research, 57. pp. 203-208. ISSN 2671-1079 (P-ISSN) , 2671-2008 (E-ISSN) https://hrcak.srce.hr/file/374355 https://doi.org/10.20471/dec.2021.57.02.08 https://doi.org/10.20471/dec.2021.57.02.08 |
| spellingShingle | RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry Mohd Amiruddin Mohd Kassim Pang, Nicholas Tze Ping Muhammad Haniff Abdullah Norharlina Bahar A case of potential inborn error of metabolism as a cause of young onset psychosis |
| title | A case of potential inborn error of metabolism as a cause of young onset psychosis |
| title_full | A case of potential inborn error of metabolism as a cause of young onset psychosis |
| title_fullStr | A case of potential inborn error of metabolism as a cause of young onset psychosis |
| title_full_unstemmed | A case of potential inborn error of metabolism as a cause of young onset psychosis |
| title_short | A case of potential inborn error of metabolism as a cause of young onset psychosis |
| title_sort | case of potential inborn error of metabolism as a cause of young onset psychosis |
| topic | RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry |
| url | https://eprints.ums.edu.my/id/eprint/32621/1/A%20case%20of%20potential%20inborn%20error%20of%20metabolism%20as%20a%20cause%20of%20young%20onset%20psychosis.pdf https://eprints.ums.edu.my/id/eprint/32621/2/A%20case%20of%20potential%20inborn%20error%20of%20metabolism%20as%20a%20cause%20of%20young%20onset%20psychosis%20_ABSTRACT.pdf |
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