Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery
Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as anticancer, anti-TB, antifungal, antimicrobial, an...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/33760/1/Therapeutic%20Outcomes%20of%20Isatin%20and%20Its%20Derivatives%20against%20Multiple%20Diseases.pdf https://eprints.ums.edu.my/id/eprint/33760/2/Therapeutic%20Outcomes%20of%20Isatin%20and%20Its%20Derivatives%20against%20Multiple%20Diseases1.pdf |
| _version_ | 1825714936042487808 |
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| author | Rameshwar S. Cheke Vaishali M. Patil Sandip D. Firke Jaya P. Ambhore Iqrar A. Ansari Harun M. Patel Sachin D. Shinde Visweswara Rao Pasupuleti Md Imtaiyaz Hassan Mohd Adnan Adel Kadri Mejdi Snoussi |
| author_facet | Rameshwar S. Cheke Vaishali M. Patil Sandip D. Firke Jaya P. Ambhore Iqrar A. Ansari Harun M. Patel Sachin D. Shinde Visweswara Rao Pasupuleti Md Imtaiyaz Hassan Mohd Adnan Adel Kadri Mejdi Snoussi |
| author_sort | Rameshwar S. Cheke |
| collection | UMS |
| description | Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as anticancer, anti-TB, antifungal, antimicrobial, antioxidant, anti-inflammatory, anticonvulsant, anti-HIV, and so on. Many research chemists take advantage of the gentle structure of isatins, such as NH at position 1 and carbonyl functions at positions 2 and 3, for designing biologically active analogues via different approaches. Literature surveys based on reported preclinical, clinical, and patented details confirm the multitarget profile of isatin analogues and thus their importance in the field of medicinal chemistry as a potent chemotherapeutic agent. This review represents the recent development of isatin analogues possessing potential pharmacological action in the years 2016–2020. The structure–activity relationship is also discussed to provide a pharmacophoric pattern that may contribute in the future to the design and synthesis of potent and less toxic therapeutics. |
| first_indexed | 2024-03-06T03:19:09Z |
| format | Article |
| id | ums.eprints-33760 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:19:09Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | ums.eprints-337602022-08-15T03:41:34Z https://eprints.ums.edu.my/id/eprint/33760/ Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery Rameshwar S. Cheke Vaishali M. Patil Sandip D. Firke Jaya P. Ambhore Iqrar A. Ansari Harun M. Patel Sachin D. Shinde Visweswara Rao Pasupuleti Md Imtaiyaz Hassan Mohd Adnan Adel Kadri Mejdi Snoussi RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RM300-666 Drugs and their actions Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as anticancer, anti-TB, antifungal, antimicrobial, antioxidant, anti-inflammatory, anticonvulsant, anti-HIV, and so on. Many research chemists take advantage of the gentle structure of isatins, such as NH at position 1 and carbonyl functions at positions 2 and 3, for designing biologically active analogues via different approaches. Literature surveys based on reported preclinical, clinical, and patented details confirm the multitarget profile of isatin analogues and thus their importance in the field of medicinal chemistry as a potent chemotherapeutic agent. This review represents the recent development of isatin analogues possessing potential pharmacological action in the years 2016–2020. The structure–activity relationship is also discussed to provide a pharmacophoric pattern that may contribute in the future to the design and synthesis of potent and less toxic therapeutics. Multidisciplinary Digital Publishing Institute 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/33760/1/Therapeutic%20Outcomes%20of%20Isatin%20and%20Its%20Derivatives%20against%20Multiple%20Diseases.pdf text en https://eprints.ums.edu.my/id/eprint/33760/2/Therapeutic%20Outcomes%20of%20Isatin%20and%20Its%20Derivatives%20against%20Multiple%20Diseases1.pdf Rameshwar S. Cheke and Vaishali M. Patil and Sandip D. Firke and Jaya P. Ambhore and Iqrar A. Ansari and Harun M. Patel and Sachin D. Shinde and Visweswara Rao Pasupuleti and Md Imtaiyaz Hassan and Mohd Adnan and Adel Kadri and Mejdi Snoussi (2022) Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery. Pharmaceuticals, 15. pp. 1-34. ISSN 1424-8247 https://www.mdpi.com/1424-8247/15/3/272 https://doi.org/10.3390/ph15030272 https://doi.org/10.3390/ph15030272 |
| spellingShingle | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RM300-666 Drugs and their actions Rameshwar S. Cheke Vaishali M. Patil Sandip D. Firke Jaya P. Ambhore Iqrar A. Ansari Harun M. Patel Sachin D. Shinde Visweswara Rao Pasupuleti Md Imtaiyaz Hassan Mohd Adnan Adel Kadri Mejdi Snoussi Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery |
| title | Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery |
| title_full | Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery |
| title_fullStr | Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery |
| title_full_unstemmed | Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery |
| title_short | Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery |
| title_sort | therapeutic outcomes of isatin and its derivatives against multiple diseases recent developments in drug discovery |
| topic | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RM300-666 Drugs and their actions |
| url | https://eprints.ums.edu.my/id/eprint/33760/1/Therapeutic%20Outcomes%20of%20Isatin%20and%20Its%20Derivatives%20against%20Multiple%20Diseases.pdf https://eprints.ums.edu.my/id/eprint/33760/2/Therapeutic%20Outcomes%20of%20Isatin%20and%20Its%20Derivatives%20against%20Multiple%20Diseases1.pdf |
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