Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia
Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen that causes severe morbidity, mortality and high medical expenses in many hospitals worldwide. The present study aimed to determine the prevalence of MRSA nosocomial infection, its associated factors, and its antimicro...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Penerbit UKM
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/33763/1/Prevalence%20of%20Methicillin-Resistant%20Staphylococcus%20aureus%20at%20a%20Tertiary%20Teaching%20Hospital%20in%20Malaysia.pdf https://eprints.ums.edu.my/id/eprint/33763/2/Prevalence%20of%20Methicillin-Resistant%20Staphylococcus%20aureus%20at%20a%20Tertiary%20Teaching%20Hospital%20in%20Malaysia%20_ABSTRACT.pdf |
| _version_ | 1796911462098141184 |
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| author | Mohd Rohaizat Hassan Nor Rumaizah MN Mohd ‘Ammar IAZ Mohd Nazrin J Sharifah Azura S Intan Kartina AK Mohammad Saffree Jeffree Syed Sharizman Syed Abdul Rahim Mohd Firdaus Mohd Hayati Hasanain FG |
| author_facet | Mohd Rohaizat Hassan Nor Rumaizah MN Mohd ‘Ammar IAZ Mohd Nazrin J Sharifah Azura S Intan Kartina AK Mohammad Saffree Jeffree Syed Sharizman Syed Abdul Rahim Mohd Firdaus Mohd Hayati Hasanain FG |
| author_sort | Mohd Rohaizat Hassan |
| collection | UMS |
| description | Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen that causes severe morbidity, mortality and high medical expenses in many hospitals worldwide. The present study aimed to determine the prevalence of MRSA nosocomial infection, its associated factors, and its antimicrobial susceptibility pattern. This was a retrospective analysis of a database of Multidrug-Resistant Organism (MDRO) that was cultured from patients admitted to Hospital Canselor Tuanku Mukhriz (HCTM) over a period of 2 years (2018-2019). MRSA accounted for 23.6% of total MDRO isolates. The male gender had a higher risk for MRSA acquisition (p<0.05), while the most prevalent setting for MRSA was the orthopaedic ward (47.5%) followed by the medical ward (29.4%). The MRSA strains were significantly isolated from respiratory specimens (55.6%) followed by tissue (50.8%) and blood (27.8%). All MRSA isolates were resistant to penicillin G, oxacillin followed by ciprofloxacin (83.8%) erythromycin (71.5%) and clindamycin (53.5%). MRSA isolates were most susceptible to teicoplanin (99.7%), mupirocin (99.3%), co-trimoxazole (98.4%), rifampicin (97.8%), doxycycline (97.4%), linezolid (95.8%), gentamicin (93.9%) and fusidic acid (86.2%). The trend for MRSA’s antibiotic susceptibility in HCTM for the past 2 years (2018 to 2019) remains unchanged. Further research will be required to investigate the predictor of MRSA by clearly differentiating between MRSA infections and colonisations, hospital-acquired MRSA and community-acquired MRSA. |
| first_indexed | 2024-03-06T03:19:10Z |
| format | Article |
| id | ums.eprints-33763 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:19:10Z |
| publishDate | 2022 |
| publisher | Penerbit UKM |
| record_format | dspace |
| spelling | ums.eprints-337632022-08-15T04:20:04Z https://eprints.ums.edu.my/id/eprint/33763/ Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia Mohd Rohaizat Hassan Nor Rumaizah MN Mohd ‘Ammar IAZ Mohd Nazrin J Sharifah Azura S Intan Kartina AK Mohammad Saffree Jeffree Syed Sharizman Syed Abdul Rahim Mohd Firdaus Mohd Hayati Hasanain FG QR75-99.5 Bacteria RA421-790.95 Public health. Hygiene. Preventive medicine Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen that causes severe morbidity, mortality and high medical expenses in many hospitals worldwide. The present study aimed to determine the prevalence of MRSA nosocomial infection, its associated factors, and its antimicrobial susceptibility pattern. This was a retrospective analysis of a database of Multidrug-Resistant Organism (MDRO) that was cultured from patients admitted to Hospital Canselor Tuanku Mukhriz (HCTM) over a period of 2 years (2018-2019). MRSA accounted for 23.6% of total MDRO isolates. The male gender had a higher risk for MRSA acquisition (p<0.05), while the most prevalent setting for MRSA was the orthopaedic ward (47.5%) followed by the medical ward (29.4%). The MRSA strains were significantly isolated from respiratory specimens (55.6%) followed by tissue (50.8%) and blood (27.8%). All MRSA isolates were resistant to penicillin G, oxacillin followed by ciprofloxacin (83.8%) erythromycin (71.5%) and clindamycin (53.5%). MRSA isolates were most susceptible to teicoplanin (99.7%), mupirocin (99.3%), co-trimoxazole (98.4%), rifampicin (97.8%), doxycycline (97.4%), linezolid (95.8%), gentamicin (93.9%) and fusidic acid (86.2%). The trend for MRSA’s antibiotic susceptibility in HCTM for the past 2 years (2018 to 2019) remains unchanged. Further research will be required to investigate the predictor of MRSA by clearly differentiating between MRSA infections and colonisations, hospital-acquired MRSA and community-acquired MRSA. Penerbit UKM 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/33763/1/Prevalence%20of%20Methicillin-Resistant%20Staphylococcus%20aureus%20at%20a%20Tertiary%20Teaching%20Hospital%20in%20Malaysia.pdf text en https://eprints.ums.edu.my/id/eprint/33763/2/Prevalence%20of%20Methicillin-Resistant%20Staphylococcus%20aureus%20at%20a%20Tertiary%20Teaching%20Hospital%20in%20Malaysia%20_ABSTRACT.pdf Mohd Rohaizat Hassan and Nor Rumaizah MN and Mohd ‘Ammar IAZ and Mohd Nazrin J and Sharifah Azura S and Intan Kartina AK and Mohammad Saffree Jeffree and Syed Sharizman Syed Abdul Rahim and Mohd Firdaus Mohd Hayati and Hasanain FG (2022) Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia. Medicine & Health, 17. pp. 133-143. ISSN 2289-5728 https://medicineandhealthukm.com/sites/medicineandhealthukm.com/files/article/2022/10_ms0531_pdf_20689.pdf https://doi.org/10.17576/MH.2022.1701.10 https://doi.org/10.17576/MH.2022.1701.10 |
| spellingShingle | QR75-99.5 Bacteria RA421-790.95 Public health. Hygiene. Preventive medicine Mohd Rohaizat Hassan Nor Rumaizah MN Mohd ‘Ammar IAZ Mohd Nazrin J Sharifah Azura S Intan Kartina AK Mohammad Saffree Jeffree Syed Sharizman Syed Abdul Rahim Mohd Firdaus Mohd Hayati Hasanain FG Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia |
| title | Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia |
| title_full | Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia |
| title_fullStr | Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia |
| title_full_unstemmed | Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia |
| title_short | Prevalence of Methicillin-Resistant Staphylococcus aureus at a Tertiary Teaching Hospital in Malaysia |
| title_sort | prevalence of methicillin resistant staphylococcus aureus at a tertiary teaching hospital in malaysia |
| topic | QR75-99.5 Bacteria RA421-790.95 Public health. Hygiene. Preventive medicine |
| url | https://eprints.ums.edu.my/id/eprint/33763/1/Prevalence%20of%20Methicillin-Resistant%20Staphylococcus%20aureus%20at%20a%20Tertiary%20Teaching%20Hospital%20in%20Malaysia.pdf https://eprints.ums.edu.my/id/eprint/33763/2/Prevalence%20of%20Methicillin-Resistant%20Staphylococcus%20aureus%20at%20a%20Tertiary%20Teaching%20Hospital%20in%20Malaysia%20_ABSTRACT.pdf |
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