Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis
Tumour lysis syndrome is common in haematological malignancies but is rarely reported in solid tumours. Peripheral blood lymphocytosis is an autoimmune feature of thymomas. We report a 63-year-old female who presented with a mediastinal mass, spontaneous tumour lysis syndrome and a leukoerythroblast...
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| Format: | Article |
| Language: | English English |
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SAGE Publications
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/33786/1/Spontaneous%20tumour%20lysis%20syndrome%20as%20a%20rare%20presentation%20of%20thymoma%20with%20peripheral%20blood%20lymphocytosis.pdf https://eprints.ums.edu.my/id/eprint/33786/2/Spontaneous%20tumour%20lysis%20syndrome%20as%20a%20rare%20presentation%20of%20thymoma%20with%20peripheral%20blood%20lymphocytosis%20_ABSTRACT.pdf |
| _version_ | 1825714938567458816 |
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| author | Larry Ellee Nyanti Sing, Andy Ong Tang Adam Malik Ismail Lee, Ping Chew Tze, Shin Leong |
| author_facet | Larry Ellee Nyanti Sing, Andy Ong Tang Adam Malik Ismail Lee, Ping Chew Tze, Shin Leong |
| author_sort | Larry Ellee Nyanti |
| collection | UMS |
| description | Tumour lysis syndrome is common in haematological malignancies but is rarely reported in solid tumours. Peripheral blood lymphocytosis is an autoimmune feature of thymomas. We report a 63-year-old female who presented with a mediastinal mass, spontaneous tumour lysis syndrome and a leukoerythroblastic picture on peripheral blood film. Bone marrow aspiration and trephine biopsy ruled out haematological malignancy. Subsequent biopsy of the mediastinal mass confirmed thymoma. This is the first reported case of thymoma with peripheral blood lymphocytosis presenting with spontaneous tumour lysis syndrome. Clinicians are reminded that solid tumours may masquerade as haematological malignancies in the presence of peripheral blood lymphocytosis, hence careful clinical evaluation is needed to differentiate between the two diagnoses. |
| first_indexed | 2024-03-06T03:19:12Z |
| format | Article |
| id | ums.eprints-33786 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:19:12Z |
| publishDate | 2022 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | ums.eprints-337862022-08-16T01:33:08Z https://eprints.ums.edu.my/id/eprint/33786/ Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis Larry Ellee Nyanti Sing, Andy Ong Tang Adam Malik Ismail Lee, Ping Chew Tze, Shin Leong RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Tumour lysis syndrome is common in haematological malignancies but is rarely reported in solid tumours. Peripheral blood lymphocytosis is an autoimmune feature of thymomas. We report a 63-year-old female who presented with a mediastinal mass, spontaneous tumour lysis syndrome and a leukoerythroblastic picture on peripheral blood film. Bone marrow aspiration and trephine biopsy ruled out haematological malignancy. Subsequent biopsy of the mediastinal mass confirmed thymoma. This is the first reported case of thymoma with peripheral blood lymphocytosis presenting with spontaneous tumour lysis syndrome. Clinicians are reminded that solid tumours may masquerade as haematological malignancies in the presence of peripheral blood lymphocytosis, hence careful clinical evaluation is needed to differentiate between the two diagnoses. SAGE Publications 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/33786/1/Spontaneous%20tumour%20lysis%20syndrome%20as%20a%20rare%20presentation%20of%20thymoma%20with%20peripheral%20blood%20lymphocytosis.pdf text en https://eprints.ums.edu.my/id/eprint/33786/2/Spontaneous%20tumour%20lysis%20syndrome%20as%20a%20rare%20presentation%20of%20thymoma%20with%20peripheral%20blood%20lymphocytosis%20_ABSTRACT.pdf Larry Ellee Nyanti and Sing, Andy Ong Tang and Adam Malik Ismail and Lee, Ping Chew and Tze, Shin Leong (2022) Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis. Proceedings of Singapore Healthcare, 31. pp. 1-3. ISSN 2010-1058 (P-ISSN) , 2059-2329 (E-ISSN) https://journals.sagepub.com/doi/pdf/10.1177/20101058221089989 https://doi.org/10.1177/20101058221089989 https://doi.org/10.1177/20101058221089989 |
| spellingShingle | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Larry Ellee Nyanti Sing, Andy Ong Tang Adam Malik Ismail Lee, Ping Chew Tze, Shin Leong Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis |
| title | Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis |
| title_full | Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis |
| title_fullStr | Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis |
| title_full_unstemmed | Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis |
| title_short | Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis |
| title_sort | spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis |
| topic | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| url | https://eprints.ums.edu.my/id/eprint/33786/1/Spontaneous%20tumour%20lysis%20syndrome%20as%20a%20rare%20presentation%20of%20thymoma%20with%20peripheral%20blood%20lymphocytosis.pdf https://eprints.ums.edu.my/id/eprint/33786/2/Spontaneous%20tumour%20lysis%20syndrome%20as%20a%20rare%20presentation%20of%20thymoma%20with%20peripheral%20blood%20lymphocytosis%20_ABSTRACT.pdf |
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