Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines
A review of the current literature indicates that natural seaweeds are an excellent source of bioactive compounds with antioxidant, antimicrobial and antitumor properties. In the present study, 90% methanolic, 70% acetonic and aqueous extracts from Kappaphycus alvarezii (strains Crocodile, Giant and...
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| Format: | Article |
| Language: | English English |
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Universiti Kebangsaan Malaysia
2014
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| Online Access: | https://eprints.ums.edu.my/id/eprint/33802/1/Antiproliferative%20Potential%20of%20Extracts%20from%20Kappaphycus%20Seaweeds%20on%20HeLa%20Cancer%20Cell%20Lines.pdf https://eprints.ums.edu.my/id/eprint/33802/2/Antiproliferative%20Potential%20of%20Extracts%20from%20Kappaphycus%20Seaweeds%20on%20HeLa%20Cancer%20Cell%20Lines1.pdf |
| _version_ | 1796911467162763264 |
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| author | Lau, Tiek Ying Delbora Fenny Vittal Chew, Cassandra Sze Yii Yong, Wilson Thau Lym |
| author_facet | Lau, Tiek Ying Delbora Fenny Vittal Chew, Cassandra Sze Yii Yong, Wilson Thau Lym |
| author_sort | Lau, Tiek Ying |
| collection | UMS |
| description | A review of the current literature indicates that natural seaweeds are an excellent source of bioactive compounds with antioxidant, antimicrobial and antitumor properties. In the present study, 90% methanolic, 70% acetonic and aqueous extracts from Kappaphycus alvarezii (strains Crocodile, Giant and Brown) and Kappaphycus striatum were used to inhibit the growth of HeLa cell lines. MTS assay was carried out to determine the proliferation of HeLa cells in the presence of different seaweed extracts. Both 500 µg/mL of aqueous and methanolic extracts from K. striatum demonstrated highest anti-proliferative activity against HeLa cells with cell growth inhibition of 53.5 and 43.7%, respectively. Treatment with the aqueous extracts from three strains of K. alvarezii did not show any growth inhibition against HeLa cell lines. The acetonic extract of Kappaphycus seaweeds exhibited a very poor cell growth inhibition with inhibitory activity observed under the treatment of 300 to 500 µg/mL of K. alvarezii strain Brown only. Further studies are suggested to identify and purify the specific anti-tumoral compounds for potential use in cancer therapy. |
| first_indexed | 2024-03-06T03:19:14Z |
| format | Article |
| id | ums.eprints-33802 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:19:14Z |
| publishDate | 2014 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | dspace |
| spelling | ums.eprints-338022022-08-16T06:54:54Z https://eprints.ums.edu.my/id/eprint/33802/ Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines Lau, Tiek Ying Delbora Fenny Vittal Chew, Cassandra Sze Yii Yong, Wilson Thau Lym SH393 Seagrasses TX341-641 Nutrition. Foods and food supply A review of the current literature indicates that natural seaweeds are an excellent source of bioactive compounds with antioxidant, antimicrobial and antitumor properties. In the present study, 90% methanolic, 70% acetonic and aqueous extracts from Kappaphycus alvarezii (strains Crocodile, Giant and Brown) and Kappaphycus striatum were used to inhibit the growth of HeLa cell lines. MTS assay was carried out to determine the proliferation of HeLa cells in the presence of different seaweed extracts. Both 500 µg/mL of aqueous and methanolic extracts from K. striatum demonstrated highest anti-proliferative activity against HeLa cells with cell growth inhibition of 53.5 and 43.7%, respectively. Treatment with the aqueous extracts from three strains of K. alvarezii did not show any growth inhibition against HeLa cell lines. The acetonic extract of Kappaphycus seaweeds exhibited a very poor cell growth inhibition with inhibitory activity observed under the treatment of 300 to 500 µg/mL of K. alvarezii strain Brown only. Further studies are suggested to identify and purify the specific anti-tumoral compounds for potential use in cancer therapy. Universiti Kebangsaan Malaysia 2014 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/33802/1/Antiproliferative%20Potential%20of%20Extracts%20from%20Kappaphycus%20Seaweeds%20on%20HeLa%20Cancer%20Cell%20Lines.pdf text en https://eprints.ums.edu.my/id/eprint/33802/2/Antiproliferative%20Potential%20of%20Extracts%20from%20Kappaphycus%20Seaweeds%20on%20HeLa%20Cancer%20Cell%20Lines1.pdf Lau, Tiek Ying and Delbora Fenny Vittal and Chew, Cassandra Sze Yii and Yong, Wilson Thau Lym (2014) Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines. Sains Malaysiana, 43. pp. 1895-1900. ISSN 0126-6039 http://journalarticle.ukm.my/8150/1/11_Tiek_Ying_Lau.pdf |
| spellingShingle | SH393 Seagrasses TX341-641 Nutrition. Foods and food supply Lau, Tiek Ying Delbora Fenny Vittal Chew, Cassandra Sze Yii Yong, Wilson Thau Lym Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines |
| title | Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines |
| title_full | Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines |
| title_fullStr | Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines |
| title_full_unstemmed | Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines |
| title_short | Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines |
| title_sort | antiproliferative potential of extracts from kappaphycus seaweeds on hela cancer cell lines |
| topic | SH393 Seagrasses TX341-641 Nutrition. Foods and food supply |
| url | https://eprints.ums.edu.my/id/eprint/33802/1/Antiproliferative%20Potential%20of%20Extracts%20from%20Kappaphycus%20Seaweeds%20on%20HeLa%20Cancer%20Cell%20Lines.pdf https://eprints.ums.edu.my/id/eprint/33802/2/Antiproliferative%20Potential%20of%20Extracts%20from%20Kappaphycus%20Seaweeds%20on%20HeLa%20Cancer%20Cell%20Lines1.pdf |
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