Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework
Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, b...
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| Format: | Article |
| Language: | English English |
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BioMed Central Ltd.
2019
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| Online Access: | https://eprints.ums.edu.my/id/eprint/34001/1/Defining%20the%20ecological%20and%20evolutionary%20drivers%20of%20Plasmodium%20knowlesi%20transmission%20within%20a%20multi-scale%20framework.ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/34001/2/Defining%20the%20ecological%20and%20evolutionary%20drivers%20of%20Plasmodium%20knowlesi%20transmission%20within%20a%20multi-scale%20framework.pdf |
| _version_ | 1825714977236844544 |
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| author | Gael Davidson Tock, Hing Chua Angus Cook Peter Speldewinde Philip Weinstein |
| author_facet | Gael Davidson Tock, Hing Chua Angus Cook Peter Speldewinde Philip Weinstein |
| author_sort | Gael Davidson |
| collection | UMS |
| description | Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Having access to human hosts provides the parasite with the opportunity to further its adaption to the human immune system. The ecological drivers of the transmission and spread of P. knowlesi are operating over many different spatial (and, therefore, temporal) scales, from the molecular to the continental. Strategies to prevent and manage zoonoses, such as P. knowlesi malaria require interdisciplinary research exploring the impact of land use change and biodiversity loss on the evolving relationship between parasite, reservoir hosts, vectors, and humans over multiple spatial scales. |
| first_indexed | 2024-03-06T03:19:47Z |
| format | Article |
| id | ums.eprints-34001 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:19:47Z |
| publishDate | 2019 |
| publisher | BioMed Central Ltd. |
| record_format | dspace |
| spelling | ums.eprints-340012022-08-29T01:58:50Z https://eprints.ums.edu.my/id/eprint/34001/ Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework Gael Davidson Tock, Hing Chua Angus Cook Peter Speldewinde Philip Weinstein QL360-599.82 Invertebrates Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Having access to human hosts provides the parasite with the opportunity to further its adaption to the human immune system. The ecological drivers of the transmission and spread of P. knowlesi are operating over many different spatial (and, therefore, temporal) scales, from the molecular to the continental. Strategies to prevent and manage zoonoses, such as P. knowlesi malaria require interdisciplinary research exploring the impact of land use change and biodiversity loss on the evolving relationship between parasite, reservoir hosts, vectors, and humans over multiple spatial scales. BioMed Central Ltd. 2019-03 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34001/1/Defining%20the%20ecological%20and%20evolutionary%20drivers%20of%20Plasmodium%20knowlesi%20transmission%20within%20a%20multi-scale%20framework.ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/34001/2/Defining%20the%20ecological%20and%20evolutionary%20drivers%20of%20Plasmodium%20knowlesi%20transmission%20within%20a%20multi-scale%20framework.pdf Gael Davidson and Tock, Hing Chua and Angus Cook and Peter Speldewinde and Philip Weinstein (2019) Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework. Malaria Journal, 18. pp. 1-13. ISSN 1475-2875 https://link.springer.com/article/10.1186/s12936-019-2693-2 https://doi.org/10.1186/s12936-019-2693-2 https://doi.org/10.1186/s12936-019-2693-2 |
| spellingShingle | QL360-599.82 Invertebrates Gael Davidson Tock, Hing Chua Angus Cook Peter Speldewinde Philip Weinstein Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
| title | Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
| title_full | Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
| title_fullStr | Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
| title_full_unstemmed | Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
| title_short | Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
| title_sort | defining the ecological and evolutionary drivers of plasmodium knowlesi transmission within a multi scale framework |
| topic | QL360-599.82 Invertebrates |
| url | https://eprints.ums.edu.my/id/eprint/34001/1/Defining%20the%20ecological%20and%20evolutionary%20drivers%20of%20Plasmodium%20knowlesi%20transmission%20within%20a%20multi-scale%20framework.ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/34001/2/Defining%20the%20ecological%20and%20evolutionary%20drivers%20of%20Plasmodium%20knowlesi%20transmission%20within%20a%20multi-scale%20framework.pdf |
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