Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway
Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of...
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| Format: | Article |
| Language: | English English |
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Multidisciplinary Digital Publishing Institute (MDPI)
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/34116/2/Mechanisms%20of%20natural%20extracts%20of%20Andrographis%20paniculata%20that%20target%20lipid-dependent%20cancer%20pathways_%20A%20view%20from%20the%20signaling%20pathway.pdf https://eprints.ums.edu.my/id/eprint/34116/3/Mechanisms%20of%20natural%20extracts%20of%20Andrographis%20paniculata%20that%20target%20lipid-dependent%20cancer%20pathways_%20A%20view%20from%20the%20signaling%20pathway%20_ABSTRACT.pdf |
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| author | Ruth Naomi Hasnah Bahari Ong, Zhi Yi Keong, Yong Yoke Hashim Embong Retnagowri Rajandram Teoh, Soo Huat Fezah Othman Rosnani Hasham Yin, Khoo Boon Priyatharisni Kaniappan Muhammad Dain Yazid Zainul Amiruddin Zakaria |
| author_facet | Ruth Naomi Hasnah Bahari Ong, Zhi Yi Keong, Yong Yoke Hashim Embong Retnagowri Rajandram Teoh, Soo Huat Fezah Othman Rosnani Hasham Yin, Khoo Boon Priyatharisni Kaniappan Muhammad Dain Yazid Zainul Amiruddin Zakaria |
| author_sort | Ruth Naomi |
| collection | UMS |
| description | Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway. |
| first_indexed | 2024-03-06T03:20:05Z |
| format | Article |
| id | ums.eprints-34116 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:20:05Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| record_format | dspace |
| spelling | ums.eprints-341162022-09-15T07:36:52Z https://eprints.ums.edu.my/id/eprint/34116/ Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway Ruth Naomi Hasnah Bahari Ong, Zhi Yi Keong, Yong Yoke Hashim Embong Retnagowri Rajandram Teoh, Soo Huat Fezah Othman Rosnani Hasham Yin, Khoo Boon Priyatharisni Kaniappan Muhammad Dain Yazid Zainul Amiruddin Zakaria QK1-989 Botany RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway. Multidisciplinary Digital Publishing Institute (MDPI) 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34116/2/Mechanisms%20of%20natural%20extracts%20of%20Andrographis%20paniculata%20that%20target%20lipid-dependent%20cancer%20pathways_%20A%20view%20from%20the%20signaling%20pathway.pdf text en https://eprints.ums.edu.my/id/eprint/34116/3/Mechanisms%20of%20natural%20extracts%20of%20Andrographis%20paniculata%20that%20target%20lipid-dependent%20cancer%20pathways_%20A%20view%20from%20the%20signaling%20pathway%20_ABSTRACT.pdf Ruth Naomi and Hasnah Bahari and Ong, Zhi Yi and Keong, Yong Yoke and Hashim Embong and Retnagowri Rajandram and Teoh, Soo Huat and Fezah Othman and Rosnani Hasham and Yin, Khoo Boon and Priyatharisni Kaniappan and Muhammad Dain Yazid and Zainul Amiruddin Zakaria (2022) Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway. International Journal of Molecular Sciences, 23 (5972). pp. 1-15. ISSN 1422-0067 https://www.mdpi.com/1422-0067/23/11/5972/htm https://doi.org/10.3390/ijms23115972 https://doi.org/10.3390/ijms23115972 |
| spellingShingle | QK1-989 Botany RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Ruth Naomi Hasnah Bahari Ong, Zhi Yi Keong, Yong Yoke Hashim Embong Retnagowri Rajandram Teoh, Soo Huat Fezah Othman Rosnani Hasham Yin, Khoo Boon Priyatharisni Kaniappan Muhammad Dain Yazid Zainul Amiruddin Zakaria Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway |
| title | Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway |
| title_full | Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway |
| title_fullStr | Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway |
| title_full_unstemmed | Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway |
| title_short | Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway |
| title_sort | mechanisms of natural extracts of andrographis paniculata that target lipid dependent cancer pathways a view from the signaling pathway |
| topic | QK1-989 Botany RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| url | https://eprints.ums.edu.my/id/eprint/34116/2/Mechanisms%20of%20natural%20extracts%20of%20Andrographis%20paniculata%20that%20target%20lipid-dependent%20cancer%20pathways_%20A%20view%20from%20the%20signaling%20pathway.pdf https://eprints.ums.edu.my/id/eprint/34116/3/Mechanisms%20of%20natural%20extracts%20of%20Andrographis%20paniculata%20that%20target%20lipid-dependent%20cancer%20pathways_%20A%20view%20from%20the%20signaling%20pathway%20_ABSTRACT.pdf |
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