Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line
Garcinia species are well-known for their unique properties of having natural secondary metabolite compounds called xanthone as well as their ethnomedicinal values such as antioxidant, anticancer, anti-inflammatory and antibacterial properties. The study was conducted to investigate the antiprolifer...
| Main Authors: | , , , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
2021
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/34444/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/34444/3/ABSTRACT.pdf |
| _version_ | 1825715055288647680 |
|---|---|
| author | N E Ahmad M F Abu Bakar Monica Suleiman F I Abu Bakar S F Sabran F Kormin |
| author_facet | N E Ahmad M F Abu Bakar Monica Suleiman F I Abu Bakar S F Sabran F Kormin |
| author_sort | N E Ahmad |
| collection | UMS |
| description | Garcinia species are well-known for their unique properties of having natural secondary metabolite compounds called xanthone as well as their ethnomedicinal values such as antioxidant, anticancer, anti-inflammatory and antibacterial properties. The study was conducted to investigate the antiproliferative activity of peel, flesh and seed extracts of G. dulcis, G. parvifolia, G. nitida, G. mangostana var. mangosta and G. cambogia collected from Malaysian Borneo (Sabah) against estrogen receptor-positive human breast carcinoma (MCF-7) cells. The antiproliferative activity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay. The results showed that G. dulcis seed induced strongest antiproliferative activity against MCF-7 cancer cell line with the IC50 value of 2.5±0.0 µg/ml, followed by G. dulcis flesh, G. mangostana var. mangostana peel and G. dulcis peel with IC50 values of 9.33 ± 3.21, 11.17 ± 1.04 and 17.67 ± 2.08 µg/ml, respectively. Meanwhile, the IC50 value for G. cambogia peel was 56.67 ± 10.5 µg/ml. No IC50 value was detected in all parts of G. parvifolia and G. nitida at concentration tested (<100 µg/ml). Overall, this study clearly showed that the whole fruit of G. dulcis displayed potent cytotoxic effect by inducing antiproliferative activity at low concentration. Further studies are needed in the future to develop this fruit as pharmaceutical and nutraceutical product for the treatment and prevention against cancer. |
| first_indexed | 2024-03-06T03:20:57Z |
| format | Conference or Workshop Item |
| id | ums.eprints-34444 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:20:57Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ums.eprints-344442022-10-12T08:24:20Z https://eprints.ums.edu.my/id/eprint/34444/ Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line N E Ahmad M F Abu Bakar Monica Suleiman F I Abu Bakar S F Sabran F Kormin RV1-431 Botanic, Thomsonian, and eclectic medicine Garcinia species are well-known for their unique properties of having natural secondary metabolite compounds called xanthone as well as their ethnomedicinal values such as antioxidant, anticancer, anti-inflammatory and antibacterial properties. The study was conducted to investigate the antiproliferative activity of peel, flesh and seed extracts of G. dulcis, G. parvifolia, G. nitida, G. mangostana var. mangosta and G. cambogia collected from Malaysian Borneo (Sabah) against estrogen receptor-positive human breast carcinoma (MCF-7) cells. The antiproliferative activity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay. The results showed that G. dulcis seed induced strongest antiproliferative activity against MCF-7 cancer cell line with the IC50 value of 2.5±0.0 µg/ml, followed by G. dulcis flesh, G. mangostana var. mangostana peel and G. dulcis peel with IC50 values of 9.33 ± 3.21, 11.17 ± 1.04 and 17.67 ± 2.08 µg/ml, respectively. Meanwhile, the IC50 value for G. cambogia peel was 56.67 ± 10.5 µg/ml. No IC50 value was detected in all parts of G. parvifolia and G. nitida at concentration tested (<100 µg/ml). Overall, this study clearly showed that the whole fruit of G. dulcis displayed potent cytotoxic effect by inducing antiproliferative activity at low concentration. Further studies are needed in the future to develop this fruit as pharmaceutical and nutraceutical product for the treatment and prevention against cancer. 2021 Conference or Workshop Item PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34444/1/FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/34444/3/ABSTRACT.pdf N E Ahmad and M F Abu Bakar and Monica Suleiman and F I Abu Bakar and S F Sabran and F Kormin (2021) Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line. In: ICB2020: International Conference on Biodiversity 2020, 4 - 5 November 2020, Melaka, Malaysia. https://iopscience.iop.org/article/10.1088/1755-1315/736/1/012004/pdf |
| spellingShingle | RV1-431 Botanic, Thomsonian, and eclectic medicine N E Ahmad M F Abu Bakar Monica Suleiman F I Abu Bakar S F Sabran F Kormin Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line |
| title | Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line |
| title_full | Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line |
| title_fullStr | Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line |
| title_full_unstemmed | Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line |
| title_short | Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line |
| title_sort | antiproliferative activity of five garcinia species collected in sabah malaysian borneo against estrogen receptor human breast carcinoma mcf 7 cell line |
| topic | RV1-431 Botanic, Thomsonian, and eclectic medicine |
| url | https://eprints.ums.edu.my/id/eprint/34444/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/34444/3/ABSTRACT.pdf |
| work_keys_str_mv | AT neahmad antiproliferativeactivityoffivegarciniaspeciescollectedinsabahmalaysianborneoagainstestrogenreceptorhumanbreastcarcinomamcf7cellline AT mfabubakar antiproliferativeactivityoffivegarciniaspeciescollectedinsabahmalaysianborneoagainstestrogenreceptorhumanbreastcarcinomamcf7cellline AT monicasuleiman antiproliferativeactivityoffivegarciniaspeciescollectedinsabahmalaysianborneoagainstestrogenreceptorhumanbreastcarcinomamcf7cellline AT fiabubakar antiproliferativeactivityoffivegarciniaspeciescollectedinsabahmalaysianborneoagainstestrogenreceptorhumanbreastcarcinomamcf7cellline AT sfsabran antiproliferativeactivityoffivegarciniaspeciescollectedinsabahmalaysianborneoagainstestrogenreceptorhumanbreastcarcinomamcf7cellline AT fkormin antiproliferativeactivityoffivegarciniaspeciescollectedinsabahmalaysianborneoagainstestrogenreceptorhumanbreastcarcinomamcf7cellline |