Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity
Biofilms are matrix-enclosed communities of bacteria that are highly resistant to antibiotics. Adding nanomaterials with antibacterial activity to the implant surfaces may be a great solution against biofilm formation. Due to its potent and widespread antibacterial effect, silver nanoparticles were...
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| Format: | Article |
| Language: | English English |
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Multidisciplinary Digital Publishing Institute (MDPI)
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/34776/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/34776/1/ABSTRACT.pdf |
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| author | Rabab A. Dorgham Mohamed N. Abd Al Moaty Chong, Khim Phin Bassma H. Elwakil |
| author_facet | Rabab A. Dorgham Mohamed N. Abd Al Moaty Chong, Khim Phin Bassma H. Elwakil |
| author_sort | Rabab A. Dorgham |
| collection | UMS |
| description | Biofilms are matrix-enclosed communities of bacteria that are highly resistant to antibiotics. Adding nanomaterials with antibacterial activity to the implant surfaces may be a great solution against biofilm formation. Due to its potent and widespread antibacterial effect, silver nanoparticles were considered the most potent agent with different biological activities. In the present investigation, silver nanoparticles (AgNPs) were newly synthesized as antibiofilm agents using sugarcane process byproduct (molasses) and named Mo-capped AgNPs. The synthesized nanoparticles showed promising antimicrobial activity against S. aureus ATCC 6538 and C. albicans DAY185. Statistically designed optimization through response surface methodology was evaluated for maximum activity and better physical characteristics, namely the nanoparticles’ size and polydispersity index (PDI), and it was revealed that molasses concentration was the main effective factor. Minimal biofilm eradication concentration (MBEC) of Mo-capped AgNPs against S. aureus ATCC 6538 and C. albicans DAY185 was 16 and 32 µg/mL, respectively. Scanning electron microscope study of Mo-capped AgNP-treated biofilm revealed that AgNPs penetrated the preformed biofilm and eradicated the microbial cells. The optimally synthesized Mo-capped AgNPs were spherically shaped, and the average size diameter ranged between 29 and 88 nm with high proportions of Ag+ element (78.0%) recorded. Fourier-transform infrared spectroscopy (FTIR) analysis indicated the importance of molasses ingredients in capping and stabilizing the produced silver nanoparticles. |
| first_indexed | 2024-03-06T03:21:54Z |
| format | Article |
| id | ums.eprints-34776 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:21:54Z |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| record_format | dspace |
| spelling | ums.eprints-347762022-11-10T01:21:09Z https://eprints.ums.edu.my/id/eprint/34776/ Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity Rabab A. Dorgham Mohamed N. Abd Al Moaty Chong, Khim Phin Bassma H. Elwakil QR75-99.5 Bacteria Biofilms are matrix-enclosed communities of bacteria that are highly resistant to antibiotics. Adding nanomaterials with antibacterial activity to the implant surfaces may be a great solution against biofilm formation. Due to its potent and widespread antibacterial effect, silver nanoparticles were considered the most potent agent with different biological activities. In the present investigation, silver nanoparticles (AgNPs) were newly synthesized as antibiofilm agents using sugarcane process byproduct (molasses) and named Mo-capped AgNPs. The synthesized nanoparticles showed promising antimicrobial activity against S. aureus ATCC 6538 and C. albicans DAY185. Statistically designed optimization through response surface methodology was evaluated for maximum activity and better physical characteristics, namely the nanoparticles’ size and polydispersity index (PDI), and it was revealed that molasses concentration was the main effective factor. Minimal biofilm eradication concentration (MBEC) of Mo-capped AgNPs against S. aureus ATCC 6538 and C. albicans DAY185 was 16 and 32 µg/mL, respectively. Scanning electron microscope study of Mo-capped AgNP-treated biofilm revealed that AgNPs penetrated the preformed biofilm and eradicated the microbial cells. The optimally synthesized Mo-capped AgNPs were spherically shaped, and the average size diameter ranged between 29 and 88 nm with high proportions of Ag+ element (78.0%) recorded. Fourier-transform infrared spectroscopy (FTIR) analysis indicated the importance of molasses ingredients in capping and stabilizing the produced silver nanoparticles. Multidisciplinary Digital Publishing Institute (MDPI) 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34776/2/FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/34776/1/ABSTRACT.pdf Rabab A. Dorgham and Mohamed N. Abd Al Moaty and Chong, Khim Phin and Bassma H. Elwakil (2022) Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity. International Journal of Molecular Sciences, 23 (10243). pp. 1-18. ISSN 1422-0067 https://www.mdpi.com/1422-0067/23/18/10243/htm https://doi.org/10.3390/ijms231810243 https://doi.org/10.3390/ijms231810243 |
| spellingShingle | QR75-99.5 Bacteria Rabab A. Dorgham Mohamed N. Abd Al Moaty Chong, Khim Phin Bassma H. Elwakil Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity |
| title | Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity |
| title_full | Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity |
| title_fullStr | Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity |
| title_full_unstemmed | Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity |
| title_short | Molasses-silver nanoparticles: synthesis, optimization, characterization, and antibiofilm activity |
| title_sort | molasses silver nanoparticles synthesis optimization characterization and antibiofilm activity |
| topic | QR75-99.5 Bacteria |
| url | https://eprints.ums.edu.my/id/eprint/34776/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/34776/1/ABSTRACT.pdf |
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