Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
Medicinal plants have been widely used for their notable health benefits and help in disease prevention for generations. In recent years, obesity has become among the risk factors of hyperglycemia and oxidation stress. This study aims to investigate the potential of plants in Sabah, North Borneo to...
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| Format: | Article |
| Language: | English English |
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Acta Scientiarum. Technology
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/34992/1/Abstract.pdf https://eprints.ums.edu.my/id/eprint/34992/2/Full%20text.pdf |
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| author | How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng |
| author_facet | How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng |
| author_sort | How, See Choon |
| collection | UMS |
| description | Medicinal plants have been widely used for their notable health benefits and help in disease prevention for generations. In recent years, obesity has become among the risk factors of hyperglycemia and oxidation stress. This study aims to investigate the potential of plants in Sabah, North Borneo to inhibit the key enzymes involved in obesity, hyperglycemia and oxidative stress. A total of 46 plant extracts were subjected to anti-pancreatic lipase, α-amylase inhibition and antioxidant assays. It was observed that S43 (Lantana camara) exhibited the greatest IC50 of anti-pancreatic lipase activity (mean of IC50 (±S.D.) = 0.20 mg mL-1 ± 0.010). Cinnamomum sp. (S42) has the most substantial α-amylase activity with a mean IC50 (±S.D.) = 2.68 mg mL-1 ± 0.471. S19 (Glochidion rubrum) was the most effective antioxidants (mean of IC50 (±S.D.) = 0.011 mg mL-1 ± 0.004) among all the investigated samples. Interestingly, three plant extracts were found (S6-Buchanania sp.; S22-Vitex negundo and S42-Cinnamomum sp.) to exhibit inhibition activity in ant pancreatic lipase, α-amylase and antioxidant assays. The bioactivities of plant extracts have been closely related to the content of phytochemicals, as in earlier studies. Thus, plants have the potential to serve as supplements and nutraceuticals for obesity and other related complications. |
| first_indexed | 2024-03-06T03:22:31Z |
| format | Article |
| id | ums.eprints-34992 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:22:31Z |
| publishDate | 2022 |
| publisher | Acta Scientiarum. Technology |
| record_format | dspace |
| spelling | ums.eprints-349922022-12-05T00:06:10Z https://eprints.ums.edu.my/id/eprint/34992/ Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng QK1-989 Botany RV1-431 Botanic, Thomsonian, and eclectic medicine Medicinal plants have been widely used for their notable health benefits and help in disease prevention for generations. In recent years, obesity has become among the risk factors of hyperglycemia and oxidation stress. This study aims to investigate the potential of plants in Sabah, North Borneo to inhibit the key enzymes involved in obesity, hyperglycemia and oxidative stress. A total of 46 plant extracts were subjected to anti-pancreatic lipase, α-amylase inhibition and antioxidant assays. It was observed that S43 (Lantana camara) exhibited the greatest IC50 of anti-pancreatic lipase activity (mean of IC50 (±S.D.) = 0.20 mg mL-1 ± 0.010). Cinnamomum sp. (S42) has the most substantial α-amylase activity with a mean IC50 (±S.D.) = 2.68 mg mL-1 ± 0.471. S19 (Glochidion rubrum) was the most effective antioxidants (mean of IC50 (±S.D.) = 0.011 mg mL-1 ± 0.004) among all the investigated samples. Interestingly, three plant extracts were found (S6-Buchanania sp.; S22-Vitex negundo and S42-Cinnamomum sp.) to exhibit inhibition activity in ant pancreatic lipase, α-amylase and antioxidant assays. The bioactivities of plant extracts have been closely related to the content of phytochemicals, as in earlier studies. Thus, plants have the potential to serve as supplements and nutraceuticals for obesity and other related complications. Acta Scientiarum. Technology 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34992/1/Abstract.pdf text en https://eprints.ums.edu.my/id/eprint/34992/2/Full%20text.pdf How, See Choon and Poh, Lucky Wah Goh and Norhaniza Johansah and Azlinah Matawali and Jualang Azlan Gansau and How, Siew Eng (2022) Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties. Acta Scientiarum. Technology, 44. pp. 1-13. ISSN 1806-2563 (P-ISSN) , 1807-8664 (E-ISSN) https://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/56879 https://doi.org/10.4025/actascitechnol.v44i1.56879 https://doi.org/10.4025/actascitechnol.v44i1.56879 |
| spellingShingle | QK1-989 Botany RV1-431 Botanic, Thomsonian, and eclectic medicine How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties |
| title | Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties |
| title_full | Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties |
| title_fullStr | Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties |
| title_full_unstemmed | Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties |
| title_short | Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties |
| title_sort | medicinal plants in sabah north borneo exhibit antipancreatic lipase anti amylase and antioxidant properties |
| topic | QK1-989 Botany RV1-431 Botanic, Thomsonian, and eclectic medicine |
| url | https://eprints.ums.edu.my/id/eprint/34992/1/Abstract.pdf https://eprints.ums.edu.my/id/eprint/34992/2/Full%20text.pdf |
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