Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates
During the third week of human pregnancy, an embryo transforms from two germinal disc layers of hypoblast and epiblast to three germinal layers of endoderm, mesoderm and ectoderm. Gastrulation is a complex process that includes cellular mobility, morphogenesis and cell signalling, as well as chemica...
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| Format: | Article |
| Language: | English English |
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Penerbit Universiti Sains Malaysia
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/35676/1/Abstract.pdf https://eprints.ums.edu.my/id/eprint/35676/2/Fulltext.pdf |
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| author | Razif Abas Siti Saleha Masrudin Ahmad Mukifza Harun Noorkardiffa Syawalina Omar |
| author_facet | Razif Abas Siti Saleha Masrudin Ahmad Mukifza Harun Noorkardiffa Syawalina Omar |
| author_sort | Razif Abas |
| collection | UMS |
| description | During the third week of human pregnancy, an embryo transforms from two germinal disc layers of hypoblast and epiblast to three germinal layers of endoderm, mesoderm and ectoderm. Gastrulation is a complex process that includes cellular mobility, morphogenesis and cell signalling, as well as chemical morphogenic gradients, transcription factors and differential gene expression. During gastrulation, many signalling channels coordinate individual cell actions in precise time and location. These channels control cell proliferation, shape, fate and migration to the correct sites. Subsequently, the anteroposterior (AP), dorsoventral (DV) and left-right (LR) body axes are formed before and during gastrulation via these signalling regulation signals. Hence, the anomalies in gastrulation caused by insults to certain molecular pathways manifest as a wide range of body axes-related disorders. This article outlines the formation of body axes during gastrulation and the anomalies as well as the clinical implications. |
| first_indexed | 2024-03-06T03:23:50Z |
| format | Article |
| id | ums.eprints-35676 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:23:50Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Sains Malaysia |
| record_format | dspace |
| spelling | ums.eprints-356762023-06-21T07:51:37Z https://eprints.ums.edu.my/id/eprint/35676/ Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates Razif Abas Siti Saleha Masrudin Ahmad Mukifza Harun Noorkardiffa Syawalina Omar QM601-695 Human embryology RG551-591 Pregnancy During the third week of human pregnancy, an embryo transforms from two germinal disc layers of hypoblast and epiblast to three germinal layers of endoderm, mesoderm and ectoderm. Gastrulation is a complex process that includes cellular mobility, morphogenesis and cell signalling, as well as chemical morphogenic gradients, transcription factors and differential gene expression. During gastrulation, many signalling channels coordinate individual cell actions in precise time and location. These channels control cell proliferation, shape, fate and migration to the correct sites. Subsequently, the anteroposterior (AP), dorsoventral (DV) and left-right (LR) body axes are formed before and during gastrulation via these signalling regulation signals. Hence, the anomalies in gastrulation caused by insults to certain molecular pathways manifest as a wide range of body axes-related disorders. This article outlines the formation of body axes during gastrulation and the anomalies as well as the clinical implications. Penerbit Universiti Sains Malaysia 2022 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/35676/1/Abstract.pdf text en https://eprints.ums.edu.my/id/eprint/35676/2/Fulltext.pdf Razif Abas and Siti Saleha Masrudin and Ahmad Mukifza Harun and Noorkardiffa Syawalina Omar (2022) Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates. The Malaysian Journal of Medical Sciences, 29. pp. 6-14. ISSN 1394-195X https://doi.org/10.21315/mjms2022.29.6.2 |
| spellingShingle | QM601-695 Human embryology RG551-591 Pregnancy Razif Abas Siti Saleha Masrudin Ahmad Mukifza Harun Noorkardiffa Syawalina Omar Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates |
| title | Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates |
| title_full | Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates |
| title_fullStr | Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates |
| title_full_unstemmed | Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates |
| title_short | Gastrulation and Body Axes Formation: A Molecular Concept and Its Clinical Correlates |
| title_sort | gastrulation and body axes formation a molecular concept and its clinical correlates |
| topic | QM601-695 Human embryology RG551-591 Pregnancy |
| url | https://eprints.ums.edu.my/id/eprint/35676/1/Abstract.pdf https://eprints.ums.edu.my/id/eprint/35676/2/Fulltext.pdf |
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