Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet
Antimicrobial resistance (AMR) has arisen as a global concern in recent decades. Plant extracts used in combination with antibiotics are promising against AMR, synergistically. The purpose of this study was to evaluate the component of the bitter ginger (Zingiber zerumbet) extract in different solve...
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| Format: | Article |
| Language: | English English |
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MDPI
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/35824/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/35824/2/FULL%20TEXT.pdf |
| _version_ | 1825715255901159424 |
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| author | Muhammad Ramzan Basit Zeshan |
| author_facet | Muhammad Ramzan Basit Zeshan |
| author_sort | Muhammad Ramzan |
| collection | UMS |
| description | Antimicrobial resistance (AMR) has arisen as a global concern in recent decades. Plant extracts used in combination with antibiotics are promising against AMR, synergistically. The purpose of this study was to evaluate the component of the bitter ginger (Zingiber zerumbet) extract in different solvents using high-performance liquid chromatography (HPLC), in addition to evaluate the antibacterial activity of these extracts, in combination with their antibiotic potential against four multidrug resistant (MDR) bacterial strains (Lactobacillus acidophilus, Streptococcus mutans, Enterococcus faecalis and Staphylococcus aureus). Ethanol and the aqueous extracts of bitter ginger were prepared using a conventional solvent extraction method and were evaluated for their phytochemistry using HPLC, qualitatively and quantitatively. Moreover, the antibiotic susceptibility of the pathogenic isolates was determined. A disc diffusion assay was used to obtain the antimicrobial potential of the extracts alone and with antibiotics. Eight components were identified from the separation of the bitter ginger extract by HPLC. For AMR bacteria, the combination of the antibiotic solution with the bitter ginger crude extracts could improve its susceptibility of these antibiotics. This study indicates that the combination of an antibiotic solution with the bitter ginger crude extract exhibits potent antibacterial activities against MDR bacterial strains. Therefore, they can be used for the treatment of various diseases against the microbial pathogen and can be incorporated into medication for antibacterial therapy. |
| first_indexed | 2024-03-06T03:24:08Z |
| format | Article |
| id | ums.eprints-35824 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:24:08Z |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | dspace |
| spelling | ums.eprints-358242023-07-12T08:11:53Z https://eprints.ums.edu.my/id/eprint/35824/ Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet Muhammad Ramzan Basit Zeshan SB183-317 Field crops Including cereals, forage crops, grasses, legumes, root crops, sugar plants, textile plants, alkaloidal plants, medicinal plants Antimicrobial resistance (AMR) has arisen as a global concern in recent decades. Plant extracts used in combination with antibiotics are promising against AMR, synergistically. The purpose of this study was to evaluate the component of the bitter ginger (Zingiber zerumbet) extract in different solvents using high-performance liquid chromatography (HPLC), in addition to evaluate the antibacterial activity of these extracts, in combination with their antibiotic potential against four multidrug resistant (MDR) bacterial strains (Lactobacillus acidophilus, Streptococcus mutans, Enterococcus faecalis and Staphylococcus aureus). Ethanol and the aqueous extracts of bitter ginger were prepared using a conventional solvent extraction method and were evaluated for their phytochemistry using HPLC, qualitatively and quantitatively. Moreover, the antibiotic susceptibility of the pathogenic isolates was determined. A disc diffusion assay was used to obtain the antimicrobial potential of the extracts alone and with antibiotics. Eight components were identified from the separation of the bitter ginger extract by HPLC. For AMR bacteria, the combination of the antibiotic solution with the bitter ginger crude extracts could improve its susceptibility of these antibiotics. This study indicates that the combination of an antibiotic solution with the bitter ginger crude extract exhibits potent antibacterial activities against MDR bacterial strains. Therefore, they can be used for the treatment of various diseases against the microbial pathogen and can be incorporated into medication for antibacterial therapy. MDPI 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/35824/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/35824/2/FULL%20TEXT.pdf Muhammad Ramzan and Basit Zeshan (2023) Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet. Molecules, 28. pp. 1-12. https://doi.org/10.3390/molecules28010409 |
| spellingShingle | SB183-317 Field crops Including cereals, forage crops, grasses, legumes, root crops, sugar plants, textile plants, alkaloidal plants, medicinal plants Muhammad Ramzan Basit Zeshan Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet |
| title | Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet |
| title_full | Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet |
| title_fullStr | Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet |
| title_full_unstemmed | Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet |
| title_short | Assessment of the Phytochemical Analysis and Antimicrobial Potentials of Zingiber zerumbet |
| title_sort | assessment of the phytochemical analysis and antimicrobial potentials of zingiber zerumbet |
| topic | SB183-317 Field crops Including cereals, forage crops, grasses, legumes, root crops, sugar plants, textile plants, alkaloidal plants, medicinal plants |
| url | https://eprints.ums.edu.my/id/eprint/35824/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/35824/2/FULL%20TEXT.pdf |
| work_keys_str_mv | AT muhammadramzan assessmentofthephytochemicalanalysisandantimicrobialpotentialsofzingiberzerumbet AT basitzeshan assessmentofthephytochemicalanalysisandantimicrobialpotentialsofzingiberzerumbet |