SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis
SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of...
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| Format: | Article |
| Language: | English English |
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Molecular Diversity Preservation International (MDPI)
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/36082/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36082/2/FULL%20TEXT.pdf |
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| author | Dayang Nooreffazleen Yahya Rhanye Mac Guad Yuan-Seng Wu Siew Hua Gan Subash C. B. Gopinath Hasif Adli Zakariah Rusdi Abdul Rashid Maw Shin Sim |
| author_facet | Dayang Nooreffazleen Yahya Rhanye Mac Guad Yuan-Seng Wu Siew Hua Gan Subash C. B. Gopinath Hasif Adli Zakariah Rusdi Abdul Rashid Maw Shin Sim |
| author_sort | Dayang Nooreffazleen Yahya |
| collection | UMS |
| description | SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of neurological diseases and psychiatric disorders. Our study investigated the association of rs4755404 single nucleotide polymorphism (SNP) of the SLC1A2 gene with methamphetamine (METH) dependence and METH-induced psychosis and mania in a Malaysian population. The rs4755404 gene polymorphism was genotyped in METH-dependent male subjects (n = 285) and male control subjects (n = 251). The subjects consisted of the four ethnic groups in Malaysia (Malay, Chinese, Kadazan-Dusun, and Bajau). Interestingly, there was a significant association between rs4755404 polymorphism and METH-induced psychosis in the pooled METH-dependent subjects in terms of genotype frequency (p = 0.041). However, there was no significant association between rs4755404 polymorphism and METH dependence. Also, the rs455404 polymorphism was not significantly associated with METH-induced mania for both genotype frequencies and allele frequencies in the METH-dependent subjects, regardless of stratification into the different ethnicities. Our study suggests that the SLC1A2 rs4755404 gene polymorphism confers some susceptibility to METH-induced psychosis, especially for those who carry the GG homozygous genotype. |
| first_indexed | 2024-03-06T03:24:19Z |
| format | Article |
| id | ums.eprints-36082 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:24:19Z |
| publishDate | 2023 |
| publisher | Molecular Diversity Preservation International (MDPI) |
| record_format | dspace |
| spelling | ums.eprints-360822023-07-20T01:37:00Z https://eprints.ums.edu.my/id/eprint/36082/ SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis Dayang Nooreffazleen Yahya Rhanye Mac Guad Yuan-Seng Wu Siew Hua Gan Subash C. B. Gopinath Hasif Adli Zakariah Rusdi Abdul Rashid Maw Shin Sim QH426-470 Genetics RC512-528 Psychoses SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of neurological diseases and psychiatric disorders. Our study investigated the association of rs4755404 single nucleotide polymorphism (SNP) of the SLC1A2 gene with methamphetamine (METH) dependence and METH-induced psychosis and mania in a Malaysian population. The rs4755404 gene polymorphism was genotyped in METH-dependent male subjects (n = 285) and male control subjects (n = 251). The subjects consisted of the four ethnic groups in Malaysia (Malay, Chinese, Kadazan-Dusun, and Bajau). Interestingly, there was a significant association between rs4755404 polymorphism and METH-induced psychosis in the pooled METH-dependent subjects in terms of genotype frequency (p = 0.041). However, there was no significant association between rs4755404 polymorphism and METH dependence. Also, the rs455404 polymorphism was not significantly associated with METH-induced mania for both genotype frequencies and allele frequencies in the METH-dependent subjects, regardless of stratification into the different ethnicities. Our study suggests that the SLC1A2 rs4755404 gene polymorphism confers some susceptibility to METH-induced psychosis, especially for those who carry the GG homozygous genotype. Molecular Diversity Preservation International (MDPI) 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/36082/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/36082/2/FULL%20TEXT.pdf Dayang Nooreffazleen Yahya and Rhanye Mac Guad and Yuan-Seng Wu and Siew Hua Gan and Subash C. B. Gopinath and Hasif Adli Zakariah and Rusdi Abdul Rashid and Maw Shin Sim (2023) SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis. Journal of Personalized Medicine, 13. pp. 1-10. https://doi.org/10.3390/jpm13020270 |
| spellingShingle | QH426-470 Genetics RC512-528 Psychoses Dayang Nooreffazleen Yahya Rhanye Mac Guad Yuan-Seng Wu Siew Hua Gan Subash C. B. Gopinath Hasif Adli Zakariah Rusdi Abdul Rashid Maw Shin Sim SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis |
| title | SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis |
| title_full | SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis |
| title_fullStr | SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis |
| title_full_unstemmed | SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis |
| title_short | SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis |
| title_sort | slc1a2 gene polymorphism influences methamphetamine induced psychosis |
| topic | QH426-470 Genetics RC512-528 Psychoses |
| url | https://eprints.ums.edu.my/id/eprint/36082/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36082/2/FULL%20TEXT.pdf |
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