Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate
A versatile synthetic matrix material for bone regeneration using electrospun fibres was introduced in this study. In this work, the electrospinning parameters were controlled to produce favourable porous fibre substrate that can aid in forming calcium phosphate during an in-vitro biomineralisation...
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| Format: | Article |
| Language: | English English |
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ResearchGate
2022
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| Online Access: | https://eprints.ums.edu.my/id/eprint/36214/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36214/4/FULL%20TEXT.pdf |
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| author | Nur Aqilah Ibrahim Nor Dalila Nor Affandi Ahmad Mukifza Harun Mohammad Khursheed Alam Noor Najmi Bonnia |
| author_facet | Nur Aqilah Ibrahim Nor Dalila Nor Affandi Ahmad Mukifza Harun Mohammad Khursheed Alam Noor Najmi Bonnia |
| author_sort | Nur Aqilah Ibrahim |
| collection | UMS |
| description | A versatile synthetic matrix material for bone regeneration using electrospun fibres was introduced in this study. In this work, the electrospinning parameters were controlled to produce favourable porous fibre substrate that can aid in forming calcium phosphate during an in-vitro biomineralisation process. The fibre substrate underwent two concentrations of simulated body fluid (SBF) to incubate the electrospun poly(ε-caprolactone) (PCL) fibre substrate at different temperatures (37 °C and 25 °C) for 7, 14, and 21 incubation days. The resultant substrate exhibited a large pore diameter with approximately 10 µm and uniform thick layer at about 0.36 ± 0.04 mm. From the SEM analysis, a hexagonal apatite structure was formed. An increase in bone apatite was observed when the SBF concentration increased from 1.0 x to 3.0 x. The EDX analysis showed that by increasing the incubation days to 21, the resultant crystal apatite decreased at body temperature of 37 °C. At room temperature of 25 °C, more crystal apatite was observed under the SEM as the incubation days increased. The current study suggested that the bioactivity of electrospun PCL substrate can be done at body temperatures as well as room temperature |
| first_indexed | 2024-03-06T03:24:26Z |
| format | Article |
| id | ums.eprints-36214 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:24:26Z |
| publishDate | 2022 |
| publisher | ResearchGate |
| record_format | dspace |
| spelling | ums.eprints-362142023-07-31T07:33:23Z https://eprints.ums.edu.my/id/eprint/36214/ Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate Nur Aqilah Ibrahim Nor Dalila Nor Affandi Ahmad Mukifza Harun Mohammad Khursheed Alam Noor Najmi Bonnia QC1-75 General QC1-999 Physics QC170-197 Atomic physics. Constitution and properties of matter A versatile synthetic matrix material for bone regeneration using electrospun fibres was introduced in this study. In this work, the electrospinning parameters were controlled to produce favourable porous fibre substrate that can aid in forming calcium phosphate during an in-vitro biomineralisation process. The fibre substrate underwent two concentrations of simulated body fluid (SBF) to incubate the electrospun poly(ε-caprolactone) (PCL) fibre substrate at different temperatures (37 °C and 25 °C) for 7, 14, and 21 incubation days. The resultant substrate exhibited a large pore diameter with approximately 10 µm and uniform thick layer at about 0.36 ± 0.04 mm. From the SEM analysis, a hexagonal apatite structure was formed. An increase in bone apatite was observed when the SBF concentration increased from 1.0 x to 3.0 x. The EDX analysis showed that by increasing the incubation days to 21, the resultant crystal apatite decreased at body temperature of 37 °C. At room temperature of 25 °C, more crystal apatite was observed under the SEM as the incubation days increased. The current study suggested that the bioactivity of electrospun PCL substrate can be done at body temperatures as well as room temperature ResearchGate 2022 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/36214/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/36214/4/FULL%20TEXT.pdf Nur Aqilah Ibrahim and Nor Dalila Nor Affandi and Ahmad Mukifza Harun and Mohammad Khursheed Alam and Noor Najmi Bonnia (2022) Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate. Malaysian Journal of Microscopy, 18 (1). pp. 1-11. ISSN 1823-7010 |
| spellingShingle | QC1-75 General QC1-999 Physics QC170-197 Atomic physics. Constitution and properties of matter Nur Aqilah Ibrahim Nor Dalila Nor Affandi Ahmad Mukifza Harun Mohammad Khursheed Alam Noor Najmi Bonnia Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate |
| title | Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate |
| title_full | Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate |
| title_fullStr | Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate |
| title_full_unstemmed | Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate |
| title_short | Effects of temperature and concentration of simulated body Fluid on bone apatite formation using electrospun poly(εcaprolactone) fibre substrate |
| title_sort | effects of temperature and concentration of simulated body fluid on bone apatite formation using electrospun poly εcaprolactone fibre substrate |
| topic | QC1-75 General QC1-999 Physics QC170-197 Atomic physics. Constitution and properties of matter |
| url | https://eprints.ums.edu.my/id/eprint/36214/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36214/4/FULL%20TEXT.pdf |
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