The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling
Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in response to altered environmental demands. The heart undergoes reversible physiological remodelling in response to changes in mechanical loading or irreversible pathological remodelling induced by neurohumor...
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| Format: | Article |
| Language: | English English |
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Molecular Diversity Preservation International (MDPI)
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/36288/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36288/2/FULL%20TEXT.pdf |
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| author | Suhaini Sudi Fiona Macniesia Thomas Siti Kadzirah Daud Dayang Maryama Ag Daud Caroline Sunggip |
| author_facet | Suhaini Sudi Fiona Macniesia Thomas Siti Kadzirah Daud Dayang Maryama Ag Daud Caroline Sunggip |
| author_sort | Suhaini Sudi |
| collection | UMS |
| description | Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in response to altered environmental demands. The heart undergoes reversible physiological remodelling in response to changes in mechanical loading or irreversible pathological remodelling induced by neurohumoral factors and chronic stress, leading to heart failure. Adenosine triphosphate (ATP) is one of the potent mediators in cardiovascular signalling that act on the ligand-gated (P2X) and G-protein-coupled (P2Y) purinoceptors via the autocrine or paracrine manners. These activations mediate numerous intracellular communications by modulating the production of other messengers, including calcium, growth factors, cytokines, and nitric oxide. ATP is known to play a pleiotropic role in cardiovascular pathophysiology, making it a reliable biomarker for cardiac protection. This review outlines the sources of ATP released under physiological and pathological stress and its cell-specific mechanism of action. We further highlight a series of cardiovascular cell-to-cell communications of extracellular ATP signalling cascades in cardiac remodelling, which can be seen in hypertension, ischemia/reperfusion injury, fibrosis, hypertrophy, and atrophy. Finally, we summarize current pharmacological intervention using the ATP network as a target for cardiac protection. A better understanding of ATP communication in myocardial remodelling could be worthwhile for future drug development and repurposing and the management of cardiovascular diseases. |
| first_indexed | 2024-03-06T03:24:36Z |
| format | Article |
| id | ums.eprints-36288 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:24:36Z |
| publishDate | 2023 |
| publisher | Molecular Diversity Preservation International (MDPI) |
| record_format | dspace |
| spelling | ums.eprints-362882023-08-04T08:51:02Z https://eprints.ums.edu.my/id/eprint/36288/ The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling Suhaini Sudi Fiona Macniesia Thomas Siti Kadzirah Daud Dayang Maryama Ag Daud Caroline Sunggip QP501-801 Animal biochemistry RA643-645 Disease (Communicable and noninfectious) and public health RC31-1245 Internal medicine Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in response to altered environmental demands. The heart undergoes reversible physiological remodelling in response to changes in mechanical loading or irreversible pathological remodelling induced by neurohumoral factors and chronic stress, leading to heart failure. Adenosine triphosphate (ATP) is one of the potent mediators in cardiovascular signalling that act on the ligand-gated (P2X) and G-protein-coupled (P2Y) purinoceptors via the autocrine or paracrine manners. These activations mediate numerous intracellular communications by modulating the production of other messengers, including calcium, growth factors, cytokines, and nitric oxide. ATP is known to play a pleiotropic role in cardiovascular pathophysiology, making it a reliable biomarker for cardiac protection. This review outlines the sources of ATP released under physiological and pathological stress and its cell-specific mechanism of action. We further highlight a series of cardiovascular cell-to-cell communications of extracellular ATP signalling cascades in cardiac remodelling, which can be seen in hypertension, ischemia/reperfusion injury, fibrosis, hypertrophy, and atrophy. Finally, we summarize current pharmacological intervention using the ATP network as a target for cardiac protection. A better understanding of ATP communication in myocardial remodelling could be worthwhile for future drug development and repurposing and the management of cardiovascular diseases. Molecular Diversity Preservation International (MDPI) 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/36288/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/36288/2/FULL%20TEXT.pdf Suhaini Sudi and Fiona Macniesia Thomas and Siti Kadzirah Daud and Dayang Maryama Ag Daud and Caroline Sunggip (2023) The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling. Molecules, 28. pp. 1-29. https://doi.org/10.3390/molecules28052102 |
| spellingShingle | QP501-801 Animal biochemistry RA643-645 Disease (Communicable and noninfectious) and public health RC31-1245 Internal medicine Suhaini Sudi Fiona Macniesia Thomas Siti Kadzirah Daud Dayang Maryama Ag Daud Caroline Sunggip The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling |
| title | The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling |
| title_full | The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling |
| title_fullStr | The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling |
| title_full_unstemmed | The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling |
| title_short | The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling |
| title_sort | pleiotropic role of extracellular atp in myocardial remodelling |
| topic | QP501-801 Animal biochemistry RA643-645 Disease (Communicable and noninfectious) and public health RC31-1245 Internal medicine |
| url | https://eprints.ums.edu.my/id/eprint/36288/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/36288/2/FULL%20TEXT.pdf |
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