Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic
Three novel concepts have been emerged in breast cancer biology: the role of cancer stem cells (CSC) in tumor initiation, and the involvement of an epithelial to mesenchymal transition (EMT) in the invasiveness and metastasis of cancer cells, along with the telomerase role in_ keeping the CSC immort...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English English |
| Published: |
2014
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/37487/1/24%20PAGES.pdf https://eprints.ums.edu.my/id/eprint/37487/2/FULLTEXT.pdf |
| _version_ | 1825715367734935552 |
|---|---|
| author | Jaafar Sadeq Makki |
| author_facet | Jaafar Sadeq Makki |
| author_sort | Jaafar Sadeq Makki |
| collection | UMS |
| description | Three novel concepts have been emerged in breast cancer biology: the role of cancer stem cells (CSC) in tumor initiation, and the involvement of an epithelial to mesenchymal transition (EMT) in the invasiveness and metastasis of cancer cells, along with the telomerase role in_ keeping the CSC immortal, and avoidino senescence. CSC are a small subpopulation of cells within tumors that initiate the tumor, telomerase is the intracellular enzyme responsible for the elongation of chromosomal telomer during each cell division, while EMT is the loss of epithelial differentiation and gained the mesenchymal phenotype. |
| first_indexed | 2024-03-06T03:25:46Z |
| format | Thesis |
| id | ums.eprints-37487 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:25:46Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ums.eprints-374872023-10-13T07:33:15Z https://eprints.ums.edu.my/id/eprint/37487/ Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic Jaafar Sadeq Makki RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Three novel concepts have been emerged in breast cancer biology: the role of cancer stem cells (CSC) in tumor initiation, and the involvement of an epithelial to mesenchymal transition (EMT) in the invasiveness and metastasis of cancer cells, along with the telomerase role in_ keeping the CSC immortal, and avoidino senescence. CSC are a small subpopulation of cells within tumors that initiate the tumor, telomerase is the intracellular enzyme responsible for the elongation of chromosomal telomer during each cell division, while EMT is the loss of epithelial differentiation and gained the mesenchymal phenotype. 2014 Thesis NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/37487/1/24%20PAGES.pdf text en https://eprints.ums.edu.my/id/eprint/37487/2/FULLTEXT.pdf Jaafar Sadeq Makki (2014) Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic. Doctoral thesis, Universiti Malaysia Sabah. |
| spellingShingle | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Jaafar Sadeq Makki Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic |
| title | Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic |
| title_full | Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic |
| title_fullStr | Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic |
| title_full_unstemmed | Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic |
| title_short | Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic |
| title_sort | expression distribution of cancer stem cell epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic |
| topic | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| url | https://eprints.ums.edu.my/id/eprint/37487/1/24%20PAGES.pdf https://eprints.ums.edu.my/id/eprint/37487/2/FULLTEXT.pdf |
| work_keys_str_mv | AT jaafarsadeqmakki expressiondistributionofcancerstemcellepithelialtomesenchymaltransitionandtelomeraseactivityinbreastcancerandtheirassociationwithclinicopathologicalcharacteristic |