Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms
Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, howe...
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| Format: | Article |
| Language: | English English |
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National Library of Medicine
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/37746/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/37746/2/FULL%20TEXT.pdf |
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| author | Khang Wen Goh Annatasha Stephen Yuan Seng Wu Maw Shin Sim Kalaivani Batumalaie Subash c.B. Gopinath Rhanye Mac Guad Ashok Kumar Mahendran Sekar Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Appalaraju Velaga Md. Moklesur Rahman Sarker |
| author_facet | Khang Wen Goh Annatasha Stephen Yuan Seng Wu Maw Shin Sim Kalaivani Batumalaie Subash c.B. Gopinath Rhanye Mac Guad Ashok Kumar Mahendran Sekar Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Appalaraju Velaga Md. Moklesur Rahman Sarker |
| author_sort | Khang Wen Goh |
| collection | UMS |
| description | Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, however, limited by poor targeting and drug delivery system. Aptamers are often utilized in the field of biomarkers identification, targeting, and as a drug/inhibitor delivery cargo. Their natural and chemically modifiable binding capability, high affinity, and specificity are favored over antibodies and potential early diagnostic imaging and drug delivery applications. Studies have demonstrated the use of different aptamers as drug delivery agents and early molecular diagnostic and detection probes for treating cancers. This review aims to first describe aptamers’ generation, characteristics, and classifications, also providing insights into their recent applications in the diagnosis and medical imaging, prognosis, and anticancer drug delivery system of GI cancers. Besides, it mainly discussed the relevant molecular targets and associated molecular mechanisms involved, as well as their applications for potential treatments for GI cancers. In addition, the current applications of aptamers in a clinical setting to treat GI cancers are deciphered. In conclusion, aptamers are multifunctional molecules that could be effectively used as an anticancer agent or drug delivery system for treating GI cancers and deserve further investigations for clinical applications. |
| first_indexed | 2024-03-06T03:26:26Z |
| format | Article |
| id | ums.eprints-37746 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:26:26Z |
| publishDate | 2023 |
| publisher | National Library of Medicine |
| record_format | dspace |
| spelling | ums.eprints-377462023-11-30T06:46:09Z https://eprints.ums.edu.my/id/eprint/37746/ Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms Khang Wen Goh Annatasha Stephen Yuan Seng Wu Maw Shin Sim Kalaivani Batumalaie Subash c.B. Gopinath Rhanye Mac Guad Ashok Kumar Mahendran Sekar Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Appalaraju Velaga Md. Moklesur Rahman Sarker QD450-801 Physical and theoretical chemistry RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Gastrointestinal (GI) cancers are among the most common cancers that impact the global population, with high mortality and low survival rates after breast and lung cancers. Identifying useful molecular targets in GI cancers are crucial for improving diagnosis, prognosis, and treatment outcomes, however, limited by poor targeting and drug delivery system. Aptamers are often utilized in the field of biomarkers identification, targeting, and as a drug/inhibitor delivery cargo. Their natural and chemically modifiable binding capability, high affinity, and specificity are favored over antibodies and potential early diagnostic imaging and drug delivery applications. Studies have demonstrated the use of different aptamers as drug delivery agents and early molecular diagnostic and detection probes for treating cancers. This review aims to first describe aptamers’ generation, characteristics, and classifications, also providing insights into their recent applications in the diagnosis and medical imaging, prognosis, and anticancer drug delivery system of GI cancers. Besides, it mainly discussed the relevant molecular targets and associated molecular mechanisms involved, as well as their applications for potential treatments for GI cancers. In addition, the current applications of aptamers in a clinical setting to treat GI cancers are deciphered. In conclusion, aptamers are multifunctional molecules that could be effectively used as an anticancer agent or drug delivery system for treating GI cancers and deserve further investigations for clinical applications. National Library of Medicine 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/37746/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/37746/2/FULL%20TEXT.pdf Khang Wen Goh and Annatasha Stephen and Yuan Seng Wu and Maw Shin Sim and Kalaivani Batumalaie and Subash c.B. Gopinath and Rhanye Mac Guad and Ashok Kumar and Mahendran Sekar and Vetriselvan Subramaniyan and Neeraj Kumar Fuloria and Shivkanya Fuloria and Appalaraju Velaga and Md. Moklesur Rahman Sarker (2023) Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms. Journal of Cancer, 14 (13). pp. 1-26. https://doi.org/10.7150/jca.85260 |
| spellingShingle | QD450-801 Physical and theoretical chemistry RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Khang Wen Goh Annatasha Stephen Yuan Seng Wu Maw Shin Sim Kalaivani Batumalaie Subash c.B. Gopinath Rhanye Mac Guad Ashok Kumar Mahendran Sekar Vetriselvan Subramaniyan Neeraj Kumar Fuloria Shivkanya Fuloria Appalaraju Velaga Md. Moklesur Rahman Sarker Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
| title | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
| title_full | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
| title_fullStr | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
| title_full_unstemmed | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
| title_short | Molecular Targets of Aptamers in Gastrointestinal Cancers: Cancer Detection, Therapeutic Applications, and Associated Mechanisms |
| title_sort | molecular targets of aptamers in gastrointestinal cancers cancer detection therapeutic applications and associated mechanisms |
| topic | QD450-801 Physical and theoretical chemistry RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| url | https://eprints.ums.edu.my/id/eprint/37746/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/37746/2/FULL%20TEXT.pdf |
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