A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers
Introduction: Hepatitis C virus (HCV) infection frequently leads to liver complications, such as fibrosis, cirrhosis, and hepatocellular carcinoma. The incidence of HCV infection transmission among drug abusers is concerning. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine secreted during inna...
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| 格式: | Article |
| 語言: | English English |
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Biomedical Research and Therapy
2023
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| 在線閱讀: | https://eprints.ums.edu.my/id/eprint/37908/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/37908/2/FULL%20TEXT.pdf |
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| author | Jalviana Lansayan Nur Salwani Bakar Ismail Che Noh Abdah Karimah Che Md Nor Imran Ahmad Abu Bakar Ruzilawati |
| author_facet | Jalviana Lansayan Nur Salwani Bakar Ismail Che Noh Abdah Karimah Che Md Nor Imran Ahmad Abu Bakar Ruzilawati |
| author_sort | Jalviana Lansayan |
| collection | UMS |
| description | Introduction: Hepatitis C virus (HCV) infection frequently leads to liver complications, such as fibrosis, cirrhosis, and hepatocellular carcinoma. The incidence of HCV infection transmission among drug abusers is concerning. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine secreted during innate and adaptive immune responses and plays a pivotal role in chronic inflammatory diseases. Functional single nucleotide polymorphisms in IL-1β cause it to play different roles in disease susceptibility and progression. This study aimed to investigate the association between genetic polymorphisms of pro-inflammatory cytokines (IL-1β) and HCV infection susceptibility in Malay male drug abusers. Methods: In total, 48 male Malay drug abusers were included in this retrospective case-control study. Genomic DNA was extracted from whole blood samples and analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the IL1β rs16944 and rs1143634 polymorphisms. Results: Analysis of IL-1β rs1143634 revealed that the C/C genotype was common in both the case and control groups; however, no statistical significance was observed (p = 0.068, χ 2= 3.755). Genotyping of IL-1β demonstrated that all samples were of the homozygous mutant type (T/T). Conclusion: There was no association between IL-1β polymorphism (rs1143634 and rs16944) and hepatitis C infection susceptibility among Malay male drug abusers. |
| first_indexed | 2024-03-06T03:26:53Z |
| format | Article |
| id | ums.eprints-37908 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:26:53Z |
| publishDate | 2023 |
| publisher | Biomedical Research and Therapy |
| record_format | dspace |
| spelling | ums.eprints-379082024-01-12T01:19:21Z https://eprints.ums.edu.my/id/eprint/37908/ A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers Jalviana Lansayan Nur Salwani Bakar Ismail Che Noh Abdah Karimah Che Md Nor Imran Ahmad Abu Bakar Ruzilawati RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RC799-869 Diseases of the digestive system. Gastroenterology Introduction: Hepatitis C virus (HCV) infection frequently leads to liver complications, such as fibrosis, cirrhosis, and hepatocellular carcinoma. The incidence of HCV infection transmission among drug abusers is concerning. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine secreted during innate and adaptive immune responses and plays a pivotal role in chronic inflammatory diseases. Functional single nucleotide polymorphisms in IL-1β cause it to play different roles in disease susceptibility and progression. This study aimed to investigate the association between genetic polymorphisms of pro-inflammatory cytokines (IL-1β) and HCV infection susceptibility in Malay male drug abusers. Methods: In total, 48 male Malay drug abusers were included in this retrospective case-control study. Genomic DNA was extracted from whole blood samples and analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the IL1β rs16944 and rs1143634 polymorphisms. Results: Analysis of IL-1β rs1143634 revealed that the C/C genotype was common in both the case and control groups; however, no statistical significance was observed (p = 0.068, χ 2= 3.755). Genotyping of IL-1β demonstrated that all samples were of the homozygous mutant type (T/T). Conclusion: There was no association between IL-1β polymorphism (rs1143634 and rs16944) and hepatitis C infection susceptibility among Malay male drug abusers. Biomedical Research and Therapy 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/37908/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/37908/2/FULL%20TEXT.pdf Jalviana Lansayan and Nur Salwani Bakar and Ismail Che Noh and Abdah Karimah Che Md Nor and Imran Ahmad and Abu Bakar Ruzilawati (2023) A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers. Vietnamese Journal for Medical Biotechnology and Medicine Incorporating Advances in Regenerative Medicine, 10 (2). pp. 1-8. https://doi.org/10.15419/bmrat.v10i2.794 |
| spellingShingle | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RC799-869 Diseases of the digestive system. Gastroenterology Jalviana Lansayan Nur Salwani Bakar Ismail Che Noh Abdah Karimah Che Md Nor Imran Ahmad Abu Bakar Ruzilawati A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers |
| title | A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers |
| title_full | A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers |
| title_fullStr | A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers |
| title_full_unstemmed | A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers |
| title_short | A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers |
| title_sort | preliminary study on the association between pro inflammatory cytokine il 1b polymorphisms and susceptibility to hepatitis c infection in malay male malay drug abusers |
| topic | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RC799-869 Diseases of the digestive system. Gastroenterology |
| url | https://eprints.ums.edu.my/id/eprint/37908/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/37908/2/FULL%20TEXT.pdf |
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