The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents
Breast cancer is one of the leading causes of death in a part of Borneo, which is Sabah, Malaysia, and worldwide. The anticancer activity of white mulberry (Morus alba Linnaeus) has been widely reported. However, cultivation locations, maturity levels, and extraction solvents could influence their p...
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| Format: | Article |
| Language: | English English |
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Rynnye Lyan Resources
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/38250/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38250/2/FULL%20TEXT.pdf |
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| author | Chen, C Mokhtar, R.A.M Kamaruzaman, K.A Wei, G.T.Y Nor Qhairul Izzreen, M.N |
| author_facet | Chen, C Mokhtar, R.A.M Kamaruzaman, K.A Wei, G.T.Y Nor Qhairul Izzreen, M.N |
| author_sort | Chen, C |
| collection | UMS |
| description | Breast cancer is one of the leading causes of death in a part of Borneo, which is Sabah, Malaysia, and worldwide. The anticancer activity of white mulberry (Morus alba Linnaeus) has been widely reported. However, cultivation locations, maturity levels, and extraction solvents could influence their phytochemical and pharmacological activities. The lack of anticancer investigation has hampered the development and potential use of Borneo-grown mulberry as an anticancer agent or source. This study investigated the cell cytotoxicity activity of Malaysia-grown mulberry at two maturity stages (fruits: brackish black fully ripe and red mature; leaves: young and mature) extracted using 70% (v/v) methanol, 60% (v/v) ethanol, and 65% (v/v) acetone, against a human breast cancer cell line (MCF-7). As a result, fruits demonstrated maturity-dependent cytotoxicity decrement as the red mature fruits in 70% (v/v) methanol exerted the strongest cytotoxicity (IC50 = 26.83 mg/mL). Meanwhile, the cytotoxicity of leaves revealed maturity-dependent increment as mature leaves in 60% (v/v) ethanol exhibited the strongest cytotoxicity against MCF-7 (IC50 = 2.45 mg/mL). Their cytotoxicity is possibly correlated to the anticancer-possessing phenolic acids and flavonoids in fruits; and the anticancerpossessing alkaloids and terpenes in leaves. Overall, Sabah-grown mulberry possesses substantial cytotoxicity against MCF-7, suggesting its anticancer potential as a complementary treatment for breast cancer. |
| first_indexed | 2024-03-06T03:27:48Z |
| format | Article |
| id | ums.eprints-38250 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:27:48Z |
| publishDate | 2023 |
| publisher | Rynnye Lyan Resources |
| record_format | dspace |
| spelling | ums.eprints-382502024-02-15T02:57:56Z https://eprints.ums.edu.my/id/eprint/38250/ The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents Chen, C Mokhtar, R.A.M Kamaruzaman, K.A Wei, G.T.Y Nor Qhairul Izzreen, M.N RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RM300-666 Drugs and their actions Breast cancer is one of the leading causes of death in a part of Borneo, which is Sabah, Malaysia, and worldwide. The anticancer activity of white mulberry (Morus alba Linnaeus) has been widely reported. However, cultivation locations, maturity levels, and extraction solvents could influence their phytochemical and pharmacological activities. The lack of anticancer investigation has hampered the development and potential use of Borneo-grown mulberry as an anticancer agent or source. This study investigated the cell cytotoxicity activity of Malaysia-grown mulberry at two maturity stages (fruits: brackish black fully ripe and red mature; leaves: young and mature) extracted using 70% (v/v) methanol, 60% (v/v) ethanol, and 65% (v/v) acetone, against a human breast cancer cell line (MCF-7). As a result, fruits demonstrated maturity-dependent cytotoxicity decrement as the red mature fruits in 70% (v/v) methanol exerted the strongest cytotoxicity (IC50 = 26.83 mg/mL). Meanwhile, the cytotoxicity of leaves revealed maturity-dependent increment as mature leaves in 60% (v/v) ethanol exhibited the strongest cytotoxicity against MCF-7 (IC50 = 2.45 mg/mL). Their cytotoxicity is possibly correlated to the anticancer-possessing phenolic acids and flavonoids in fruits; and the anticancerpossessing alkaloids and terpenes in leaves. Overall, Sabah-grown mulberry possesses substantial cytotoxicity against MCF-7, suggesting its anticancer potential as a complementary treatment for breast cancer. Rynnye Lyan Resources 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/38250/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/38250/2/FULL%20TEXT.pdf Chen, C and Mokhtar, R.A.M and Kamaruzaman, K.A and Wei, G.T.Y and Nor Qhairul Izzreen, M.N (2023) The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents. Food Research, 7. pp. 1-10. ISSN 2550-2166 https://doi.org/10.26656/fr.2017.7(6).519 |
| spellingShingle | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RM300-666 Drugs and their actions Chen, C Mokhtar, R.A.M Kamaruzaman, K.A Wei, G.T.Y Nor Qhairul Izzreen, M.N The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents |
| title | The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents |
| title_full | The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents |
| title_fullStr | The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents |
| title_full_unstemmed | The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents |
| title_short | The cytotoxicity activity of borneo-cultivated mulberry against breast cancer cell (MCF-7): the influence of maturity stages and extraction solvents |
| title_sort | cytotoxicity activity of borneo cultivated mulberry against breast cancer cell mcf 7 the influence of maturity stages and extraction solvents |
| topic | RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RM300-666 Drugs and their actions |
| url | https://eprints.ums.edu.my/id/eprint/38250/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38250/2/FULL%20TEXT.pdf |
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