Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs
Infectious bronchitis virus (IBV) is an avian coronavirus (CoV) that belongs to the genus Gamma coronavirus and has been listed as an important disease by the World Organization for Animal Health (WOAH). It causes highly contagious respiratory, reproductive, and renal diseases in commercial poultry...
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| Format: | Article |
| Language: | English English |
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MDPI
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/38312/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38312/2/FULL%20TEXT.pdf |
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| author | Md. Safiul Alam Bhuiyan Subir Sarker Zarina Amin Kenneth Francis Rodrigues Suryani Saallah Sharifudin Md. Shaarani Shafiquzzaman Siddiquee |
| author_facet | Md. Safiul Alam Bhuiyan Subir Sarker Zarina Amin Kenneth Francis Rodrigues Suryani Saallah Sharifudin Md. Shaarani Shafiquzzaman Siddiquee |
| author_sort | Md. Safiul Alam Bhuiyan |
| collection | UMS |
| description | Infectious bronchitis virus (IBV) is an avian coronavirus (CoV) that belongs to the genus Gamma coronavirus and has been listed as an important disease by the World Organization for Animal Health (WOAH). It causes highly contagious respiratory, reproductive, and renal diseases in commercial poultry farms. Multiple IBV serotypes and genotypes have been identified in many countries and many detected variants do not provide cross-protection against infection, resulting in repeated outbreaks and significant economic losses worldwide. In addition, the high genetic mutations and recombination events in the prominent genomic regions of IBV, particularly in the spike glycoprotein (S) and nucleocapsid (N) proteins, are directly involved in the evolutionary processes of IBV and lead to increased pathogenicity and tissue tropism. The characterization of the different genotypes and the relationship between the structure, function, post-translational modifications (PTMs), and structural motifs will elucidate the mechanisms that promote replication and pathogenicity and affect the host’s immune response during infection. In this review, we discuss the molecular features of various IBV genes and proteins that contribute to the infection process. We also highlight the common PTMs and structural motifs that occur during protein synthesis and are essential components of IBV ecology. |
| first_indexed | 2024-03-06T03:27:57Z |
| format | Article |
| id | ums.eprints-38312 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:27:57Z |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | dspace |
| spelling | ums.eprints-383122024-02-22T03:03:32Z https://eprints.ums.edu.my/id/eprint/38312/ Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs Md. Safiul Alam Bhuiyan Subir Sarker Zarina Amin Kenneth Francis Rodrigues Suryani Saallah Sharifudin Md. Shaarani Shafiquzzaman Siddiquee QR355-502 Virology SF481-507 Poultry. Eggs Infectious bronchitis virus (IBV) is an avian coronavirus (CoV) that belongs to the genus Gamma coronavirus and has been listed as an important disease by the World Organization for Animal Health (WOAH). It causes highly contagious respiratory, reproductive, and renal diseases in commercial poultry farms. Multiple IBV serotypes and genotypes have been identified in many countries and many detected variants do not provide cross-protection against infection, resulting in repeated outbreaks and significant economic losses worldwide. In addition, the high genetic mutations and recombination events in the prominent genomic regions of IBV, particularly in the spike glycoprotein (S) and nucleocapsid (N) proteins, are directly involved in the evolutionary processes of IBV and lead to increased pathogenicity and tissue tropism. The characterization of the different genotypes and the relationship between the structure, function, post-translational modifications (PTMs), and structural motifs will elucidate the mechanisms that promote replication and pathogenicity and affect the host’s immune response during infection. In this review, we discuss the molecular features of various IBV genes and proteins that contribute to the infection process. We also highlight the common PTMs and structural motifs that occur during protein synthesis and are essential components of IBV ecology. MDPI 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/38312/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/38312/2/FULL%20TEXT.pdf Md. Safiul Alam Bhuiyan and Subir Sarker and Zarina Amin and Kenneth Francis Rodrigues and Suryani Saallah and Sharifudin Md. Shaarani and Shafiquzzaman Siddiquee (2023) Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs. Poultry, 2. pp. 1-20. https://doi.org/10.3390/poultry2030027 |
| spellingShingle | QR355-502 Virology SF481-507 Poultry. Eggs Md. Safiul Alam Bhuiyan Subir Sarker Zarina Amin Kenneth Francis Rodrigues Suryani Saallah Sharifudin Md. Shaarani Shafiquzzaman Siddiquee Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs |
| title | Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs |
| title_full | Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs |
| title_fullStr | Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs |
| title_full_unstemmed | Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs |
| title_short | Infectious Bronchitis Virus (Gamma coronavirus) in Poultry: Genomic Architecture, Post-Translational Modifications, and Structural Motifs |
| title_sort | infectious bronchitis virus gamma coronavirus in poultry genomic architecture post translational modifications and structural motifs |
| topic | QR355-502 Virology SF481-507 Poultry. Eggs |
| url | https://eprints.ums.edu.my/id/eprint/38312/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38312/2/FULL%20TEXT.pdf |
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