Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study
Pleural fluid residue, or macroscopic tissue, circulating freely in the pleural fluid obtained through direct filtration, may carry diagnostic histopathological information. We aimed to determine the histopathological concordance of pleural fluid residue in diagnosing TPE and MPE, compared with conv...
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| Format: | Article |
| Language: | English English |
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South African Medical Association
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/38608/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38608/2/FULL%20TEXT.pdf |
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| author | Larry Ellee Nyanti N-C Huan H Y Ramarmuty T Renganathan M A bin Abdul Aziz J L Low K T Rosli S Letcheminan Meryl Grace Lansing K K Sivaraman Kannan |
| author_facet | Larry Ellee Nyanti N-C Huan H Y Ramarmuty T Renganathan M A bin Abdul Aziz J L Low K T Rosli S Letcheminan Meryl Grace Lansing K K Sivaraman Kannan |
| author_sort | Larry Ellee Nyanti |
| collection | UMS |
| description | Pleural fluid residue, or macroscopic tissue, circulating freely in the pleural fluid obtained through direct filtration, may carry diagnostic histopathological information. We aimed to determine the histopathological concordance of pleural fluid residue in diagnosing TPE and MPE, compared with conventional pleural biopsy. This was a prospective cohort study of consecutive inpatients with cytology-negative exudative effusion who underwent pleuroscopy and had their initial suctioned pleural fluid filtered for residue samples. Pleural fluid residue demonstrated malignant cells in four out of seven cases of pleural biopsy-confirmed malignancy. Pleural fluid residue has comparable cytomorphology, but reduced cellularity compared with pleural biopsy. No tuberculous histological features were present in the pleural fluid residue samples. In this preliminary study pleural fluid residue provided histopathological information for malignant pleural effusion, but no incremental diagnostic information for tuberculous effusion. However larger and more definitive studies are required to clarify these findings, and to explore the utility and suitability of pleural fluid residue for mutational analysis. |
| first_indexed | 2024-09-24T00:48:49Z |
| format | Article |
| id | ums.eprints-38608 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-09-24T00:48:49Z |
| publishDate | 2023 |
| publisher | South African Medical Association |
| record_format | dspace |
| spelling | ums.eprints-386082024-05-02T08:49:42Z https://eprints.ums.edu.my/id/eprint/38608/ Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study Larry Ellee Nyanti N-C Huan H Y Ramarmuty T Renganathan M A bin Abdul Aziz J L Low K T Rosli S Letcheminan Meryl Grace Lansing K K Sivaraman Kannan R5-920 Medicine (General) RB37-56.5 Clinical pathology. Laboratory technique Pleural fluid residue, or macroscopic tissue, circulating freely in the pleural fluid obtained through direct filtration, may carry diagnostic histopathological information. We aimed to determine the histopathological concordance of pleural fluid residue in diagnosing TPE and MPE, compared with conventional pleural biopsy. This was a prospective cohort study of consecutive inpatients with cytology-negative exudative effusion who underwent pleuroscopy and had their initial suctioned pleural fluid filtered for residue samples. Pleural fluid residue demonstrated malignant cells in four out of seven cases of pleural biopsy-confirmed malignancy. Pleural fluid residue has comparable cytomorphology, but reduced cellularity compared with pleural biopsy. No tuberculous histological features were present in the pleural fluid residue samples. In this preliminary study pleural fluid residue provided histopathological information for malignant pleural effusion, but no incremental diagnostic information for tuberculous effusion. However larger and more definitive studies are required to clarify these findings, and to explore the utility and suitability of pleural fluid residue for mutational analysis. South African Medical Association 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/38608/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/38608/2/FULL%20TEXT.pdf Larry Ellee Nyanti and N-C Huan and H Y Ramarmuty and T Renganathan and M A bin Abdul Aziz and J L Low and K T Rosli and S Letcheminan and Meryl Grace Lansing and K K Sivaraman Kannan (2023) Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study. The African Journal of Thoracic and Critical Care Medicine, 29 (4). pp. 171-173. ISSN 2671-0191 https://doi.org/10.7196/AJTCCM.2023.v29i4.1149 |
| spellingShingle | R5-920 Medicine (General) RB37-56.5 Clinical pathology. Laboratory technique Larry Ellee Nyanti N-C Huan H Y Ramarmuty T Renganathan M A bin Abdul Aziz J L Low K T Rosli S Letcheminan Meryl Grace Lansing K K Sivaraman Kannan Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study |
| title | Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study |
| title_full | Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study |
| title_fullStr | Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study |
| title_full_unstemmed | Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study |
| title_short | Pleural fluid residue as a diagnostic tool for cytology-negative malignant pleural effusion: A proof-of-concept study |
| title_sort | pleural fluid residue as a diagnostic tool for cytology negative malignant pleural effusion a proof of concept study |
| topic | R5-920 Medicine (General) RB37-56.5 Clinical pathology. Laboratory technique |
| url | https://eprints.ums.edu.my/id/eprint/38608/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38608/2/FULL%20TEXT.pdf |
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