Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis
The epidemiology of different respiratory viral infections is believed to be affected by prior viral infections in addition to seasonal effects. This PROSPERO-registered systematic review identified 7388 studies, of which six met our criteria to answer the question specifically. The purpose of this...
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| Format: | Article |
| Language: | English English |
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MDPI
2024
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| Online Access: | https://eprints.ums.edu.my/id/eprint/40648/5/ABSTARCT.pdf https://eprints.ums.edu.my/id/eprint/40648/2/FULLTEXT.pdf |
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| author | Vennila Gopal Chung, Matthew Yi Koh Jinghao Nicholas Ngiam Ong, Hang-Cheng Jyoti Somani Paul Anatharajah Tambyah Jeremy Tey |
| author_facet | Vennila Gopal Chung, Matthew Yi Koh Jinghao Nicholas Ngiam Ong, Hang-Cheng Jyoti Somani Paul Anatharajah Tambyah Jeremy Tey |
| author_sort | Vennila Gopal |
| collection | UMS |
| description | The epidemiology of different respiratory viral infections is believed to be affected by prior viral infections in addition to seasonal effects. This PROSPERO-registered systematic review identified 7388 studies, of which six met our criteria to answer the question specifically. The purpose of this review was to compare the prevalence of sequential viral infections in those with previously documented positive versus negative swabs. The pooled prevalence of sequential viral infections over varying periods from 30–1000 days of follow-up was higher following a negative respiratory viral swab at 0.15 than following a positive swab at 0.08, indicating the potential protective effects of prior respiratory viral infections. However, significant heterogeneity and publication biases were noted. There is some evidence, albeit of low quality, of a possible protective effect of an initial viral infection against subsequent infections by a different virus, which is possibly due to broad, nonspecific innate immunity. Future prospective studies are needed to validate our findings. |
| first_indexed | 2024-09-24T00:51:27Z |
| format | Article |
| id | ums.eprints-40648 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-09-24T00:51:27Z |
| publishDate | 2024 |
| publisher | MDPI |
| record_format | dspace |
| spelling | ums.eprints-406482024-08-16T06:47:54Z https://eprints.ums.edu.my/id/eprint/40648/ Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis Vennila Gopal Chung, Matthew Yi Koh Jinghao Nicholas Ngiam Ong, Hang-Cheng Jyoti Somani Paul Anatharajah Tambyah Jeremy Tey RC705-779 Diseases of the respiratory system The epidemiology of different respiratory viral infections is believed to be affected by prior viral infections in addition to seasonal effects. This PROSPERO-registered systematic review identified 7388 studies, of which six met our criteria to answer the question specifically. The purpose of this review was to compare the prevalence of sequential viral infections in those with previously documented positive versus negative swabs. The pooled prevalence of sequential viral infections over varying periods from 30–1000 days of follow-up was higher following a negative respiratory viral swab at 0.15 than following a positive swab at 0.08, indicating the potential protective effects of prior respiratory viral infections. However, significant heterogeneity and publication biases were noted. There is some evidence, albeit of low quality, of a possible protective effect of an initial viral infection against subsequent infections by a different virus, which is possibly due to broad, nonspecific innate immunity. Future prospective studies are needed to validate our findings. MDPI 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/40648/5/ABSTARCT.pdf text en https://eprints.ums.edu.my/id/eprint/40648/2/FULLTEXT.pdf Vennila Gopal and Chung, Matthew Yi Koh and Jinghao Nicholas Ngiam and Ong, Hang-Cheng and Jyoti Somani and Paul Anatharajah Tambyah and Jeremy Tey (2024) Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis. Viruses, 16. pp. 1-14. https://doi.org/10.3390/v16060982 |
| spellingShingle | RC705-779 Diseases of the respiratory system Vennila Gopal Chung, Matthew Yi Koh Jinghao Nicholas Ngiam Ong, Hang-Cheng Jyoti Somani Paul Anatharajah Tambyah Jeremy Tey Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis |
| title | Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis |
| title_full | Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis |
| title_fullStr | Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis |
| title_full_unstemmed | Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis |
| title_short | Does prior respiratory viral infection provide cross-protection against subsequent respiratory viral infections? A systematic review and meta-analysis |
| title_sort | does prior respiratory viral infection provide cross protection against subsequent respiratory viral infections a systematic review and meta analysis |
| topic | RC705-779 Diseases of the respiratory system |
| url | https://eprints.ums.edu.my/id/eprint/40648/5/ABSTARCT.pdf https://eprints.ums.edu.my/id/eprint/40648/2/FULLTEXT.pdf |
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