Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review
Perimenopausal depression (PMD) is a psychological disorder that occurs in women during perimenopause. In addition to the common clinical symptoms of depression, it often manifests as a perimenopausal complication, and its notable cause is the decline in estrogen levels. Despite numerous studies and...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
MDPI
2024
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/40781/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/40781/2/ABSTRACT.pdf |
| _version_ | 1811136513715470336 |
|---|---|
| author | Xiuting Xiang Praneetha Palasuberniam Rahmawati Pare |
| author_facet | Xiuting Xiang Praneetha Palasuberniam Rahmawati Pare |
| author_sort | Xiuting Xiang |
| collection | UMS |
| description | Perimenopausal depression (PMD) is a psychological disorder that occurs in women during perimenopause. In addition to the common clinical symptoms of depression, it often manifests as a perimenopausal complication, and its notable cause is the decline in estrogen levels. Despite numerous studies and trials confirming the benefits of estrogen replacement therapy (ERT) for PMD, ERT remains unapproved for treating PMD. Therefore, we conducted a literature search using selected keywords in PubMed and Google Scholar to write a review discussing the feasibility of using ERT for PMD. This review examines the potential of ERT for PMD in terms of its underlying mechanisms, efficacy, safety, and time window. These four aspects suggest that ERT is a viable option for PMD treatment. However, the risk of thrombosis and stroke with ERT is a matter of contention among medical experts, with a paucity of clinical data. Consequently, further clinical trial data are required to ascertain the safety of ERT. |
| first_indexed | 2024-09-24T00:51:40Z |
| format | Article |
| id | ums.eprints-40781 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-09-24T00:51:40Z |
| publishDate | 2024 |
| publisher | MDPI |
| record_format | dspace |
| spelling | ums.eprints-407812024-08-21T08:48:53Z https://eprints.ums.edu.my/id/eprint/40781/ Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review Xiuting Xiang Praneetha Palasuberniam Rahmawati Pare RC346-429 Neurology. Diseases of the nervous system Including speech disorders Perimenopausal depression (PMD) is a psychological disorder that occurs in women during perimenopause. In addition to the common clinical symptoms of depression, it often manifests as a perimenopausal complication, and its notable cause is the decline in estrogen levels. Despite numerous studies and trials confirming the benefits of estrogen replacement therapy (ERT) for PMD, ERT remains unapproved for treating PMD. Therefore, we conducted a literature search using selected keywords in PubMed and Google Scholar to write a review discussing the feasibility of using ERT for PMD. This review examines the potential of ERT for PMD in terms of its underlying mechanisms, efficacy, safety, and time window. These four aspects suggest that ERT is a viable option for PMD treatment. However, the risk of thrombosis and stroke with ERT is a matter of contention among medical experts, with a paucity of clinical data. Consequently, further clinical trial data are required to ascertain the safety of ERT. MDPI 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/40781/1/FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/40781/2/ABSTRACT.pdf Xiuting Xiang and Praneetha Palasuberniam and Rahmawati Pare (2024) Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review. Medicina, 60 (1076). pp. 1-12. https://doi.org/10.3390/medicina60071076 |
| spellingShingle | RC346-429 Neurology. Diseases of the nervous system Including speech disorders Xiuting Xiang Praneetha Palasuberniam Rahmawati Pare Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review |
| title | Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review |
| title_full | Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review |
| title_fullStr | Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review |
| title_full_unstemmed | Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review |
| title_short | Exploring the Feasibility of Estrogen Replacement Therapy as a Treatment for Perimenopausal Depression: A Comprehensive Literature Review |
| title_sort | exploring the feasibility of estrogen replacement therapy as a treatment for perimenopausal depression a comprehensive literature review |
| topic | RC346-429 Neurology. Diseases of the nervous system Including speech disorders |
| url | https://eprints.ums.edu.my/id/eprint/40781/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/40781/2/ABSTRACT.pdf |
| work_keys_str_mv | AT xiutingxiang exploringthefeasibilityofestrogenreplacementtherapyasatreatmentforperimenopausaldepressionacomprehensiveliteraturereview AT praneethapalasuberniam exploringthefeasibilityofestrogenreplacementtherapyasatreatmentforperimenopausaldepressionacomprehensiveliteraturereview AT rahmawatipare exploringthefeasibilityofestrogenreplacementtherapyasatreatmentforperimenopausaldepressionacomprehensiveliteraturereview |