Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model
Alzheimer’s disease is a complex neurodegenerative disease and is only unique to human. The disease is defined in human brain by the accumulation of amyloid beta in the parenchyma of the brain. Withania somnifera, commonly known as Ashwagandha is an Indian Ayurvedic medicine that has been used for c...
| Үндсэн зохиолчид: | , , , , , , , |
|---|---|
| Формат: | Өгүүллэг |
| Хэл сонгох: | English English |
| Хэвлэсэн: |
Universiti Putra Malaysia
2024
|
| Нөхцлүүд: | |
| Онлайн хандалт: | https://eprints.ums.edu.my/id/eprint/40907/1/abstract.pdf https://eprints.ums.edu.my/id/eprint/40907/4/FULLTEXT.pdf |
| _version_ | 1825715777754365952 |
|---|---|
| author | Mardani Abdul Halim Izzah Madihah Rosli Siti Shafika Muhammad Jaafar Ooi,, Hoi Min Leong, Pui Wei Shaharum Shamsuddin Nazalam Najimudin Ghows Azzam |
| author_facet | Mardani Abdul Halim Izzah Madihah Rosli Siti Shafika Muhammad Jaafar Ooi,, Hoi Min Leong, Pui Wei Shaharum Shamsuddin Nazalam Najimudin Ghows Azzam |
| author_sort | Mardani Abdul Halim |
| collection | UMS |
| description | Alzheimer’s disease is a complex neurodegenerative disease and is only unique to human. The disease is defined in human brain by the accumulation of amyloid beta in the parenchyma of the brain. Withania somnifera, commonly known as Ashwagandha is an Indian Ayurvedic medicine that has been used for centuries to treat countless range of human health problem. The active compound of Ashwagandha was shown to be beneficial in treating many neurodegenerative diseases including Alzheimer’s disease (AD). In this study, Drosophila melanogaster AD model was used to study the effect of Ashwagandha on the toxicity of beta amyloid and also the longevity effect of the compound. We found that 20 mg/mL of Ashwagandha was shown to be effective in rescuing the “rough eye phenotype” of AD Drosophila. Furthermore, Ashwagandha also promotes longevity in AD as well as wild type Drosophila. The results above showed that Ashwagandha could potentially be a potent drug to treat AD as well as maintaining the wellbeing of cells. |
| first_indexed | 2024-09-24T00:52:32Z |
| format | Article |
| id | ums.eprints-40907 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-09-24T00:52:32Z |
| publishDate | 2024 |
| publisher | Universiti Putra Malaysia |
| record_format | dspace |
| spelling | ums.eprints-409072024-09-09T07:54:36Z https://eprints.ums.edu.my/id/eprint/40907/ Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model Mardani Abdul Halim Izzah Madihah Rosli Siti Shafika Muhammad Jaafar Ooi,, Hoi Min Leong, Pui Wei Shaharum Shamsuddin Nazalam Najimudin Ghows Azzam QH426-470 Genetics RC346-429 Neurology. Diseases of the nervous system Including speech disorders Alzheimer’s disease is a complex neurodegenerative disease and is only unique to human. The disease is defined in human brain by the accumulation of amyloid beta in the parenchyma of the brain. Withania somnifera, commonly known as Ashwagandha is an Indian Ayurvedic medicine that has been used for centuries to treat countless range of human health problem. The active compound of Ashwagandha was shown to be beneficial in treating many neurodegenerative diseases including Alzheimer’s disease (AD). In this study, Drosophila melanogaster AD model was used to study the effect of Ashwagandha on the toxicity of beta amyloid and also the longevity effect of the compound. We found that 20 mg/mL of Ashwagandha was shown to be effective in rescuing the “rough eye phenotype” of AD Drosophila. Furthermore, Ashwagandha also promotes longevity in AD as well as wild type Drosophila. The results above showed that Ashwagandha could potentially be a potent drug to treat AD as well as maintaining the wellbeing of cells. Universiti Putra Malaysia 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/40907/1/abstract.pdf text en https://eprints.ums.edu.my/id/eprint/40907/4/FULLTEXT.pdf Mardani Abdul Halim and Izzah Madihah Rosli and Siti Shafika Muhammad Jaafar and Ooi,, Hoi Min and Leong, Pui Wei and Shaharum Shamsuddin and Nazalam Najimudin and Ghows Azzam (2024) Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model. Asia-Pacific Journal of Molecular Biology and Biotechnology, 32. pp. 66-70. ISSN 0128-7451 https://doi.org/10.1101/2020.04.27.063107 |
| spellingShingle | QH426-470 Genetics RC346-429 Neurology. Diseases of the nervous system Including speech disorders Mardani Abdul Halim Izzah Madihah Rosli Siti Shafika Muhammad Jaafar Ooi,, Hoi Min Leong, Pui Wei Shaharum Shamsuddin Nazalam Najimudin Ghows Azzam Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model |
| title | Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model |
| title_full | Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model |
| title_fullStr | Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model |
| title_full_unstemmed | Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model |
| title_short | Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model |
| title_sort | withania somnifera showed neuroprotective effect and increase longevity in drosophila alzheimer s disease model |
| topic | QH426-470 Genetics RC346-429 Neurology. Diseases of the nervous system Including speech disorders |
| url | https://eprints.ums.edu.my/id/eprint/40907/1/abstract.pdf https://eprints.ums.edu.my/id/eprint/40907/4/FULLTEXT.pdf |
| work_keys_str_mv | AT mardaniabdulhalim withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel AT izzahmadihahrosli withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel AT sitishafikamuhammadjaafar withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel AT ooihoimin withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel AT leongpuiwei withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel AT shaharumshamsuddin withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel AT nazalamnajimudin withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel AT ghowsazzam withaniasomniferashowedneuroprotectiveeffectandincreaselongevityindrosophilaalzheimersdiseasemodel |