Menopausal hormone therapy and risk of venous thromboembolism: the story so far
Menopausal hormone therapy (MHT) is known to increase the risk of venous thromboembolism (VTE), which includes deep vein thrombosis, pulmonary embolism, and less frequently cerebral vein thrombosis, but the absolute risk for a given patient is very low. After starting MHT, the risk of VTE seems to b...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
African Journal of Reproductive Health/Women's Health and Action Research Centre (WHARC)
2024
|
| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/41068/3/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/41068/2/FULL%20TEXT.pdf |
| _version_ | 1811136555235934208 |
|---|---|
| author | Mohsen M.A. Abdelhafez Karim A. M. Ahmed Nashwa A.M. Ahmed Mohd H. Ismail Mohd Nazri Mohd Daud Aya M. Eldiastey Mohd Fariz Amri Mohammad Saffree Jeffree Fairrul Masnah @ Kadir Dg Marshitah Pg Baharuddin Mohammad Firdaus Bolong @ Mohd Darwis Mohd Firdaus Hayati Nornazirah Azizan Doreen Sumpat Syed Sharizman Syed Abdul Rahim Win W. Than Mohd Y. Ibrahim Zhen Z. Lo May, Zaw Soe |
| author_facet | Mohsen M.A. Abdelhafez Karim A. M. Ahmed Nashwa A.M. Ahmed Mohd H. Ismail Mohd Nazri Mohd Daud Aya M. Eldiastey Mohd Fariz Amri Mohammad Saffree Jeffree Fairrul Masnah @ Kadir Dg Marshitah Pg Baharuddin Mohammad Firdaus Bolong @ Mohd Darwis Mohd Firdaus Hayati Nornazirah Azizan Doreen Sumpat Syed Sharizman Syed Abdul Rahim Win W. Than Mohd Y. Ibrahim Zhen Z. Lo May, Zaw Soe |
| author_sort | Mohsen M.A. Abdelhafez |
| collection | UMS |
| description | Menopausal hormone therapy (MHT) is known to increase the risk of venous thromboembolism (VTE), which includes deep vein thrombosis, pulmonary embolism, and less frequently cerebral vein thrombosis, but the absolute risk for a given patient is very low. After starting MHT, the risk of VTE seems to be at its highest, declining to the non-HRT user baseline level of risk after stopping. Whether estrogen-only or estrogen-progestin HRT combination is linked to a similar risk of VTE is unclear from the available evidence. The aim of this study is to evaluate the risks of developing VTE in relation to different types as well as different modes of administration of MHT through a database search including PubMed, MEDLINE, Google Scholar, Cochrane Library, and others in order to provide the women carers with the up-to-date and evidence-based guidelines and recommendations while counseling the post-menopausal women enquiring on use of hormonal therapies either to alleviate the menopausal symptoms or to prevent the longterm sequelae of estrogen deficiency. |
| first_indexed | 2024-09-24T00:52:53Z |
| format | Article |
| id | ums.eprints-41068 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-09-24T00:52:53Z |
| publishDate | 2024 |
| publisher | African Journal of Reproductive Health/Women's Health and Action Research Centre (WHARC) |
| record_format | dspace |
| spelling | ums.eprints-410682024-09-20T01:49:43Z https://eprints.ums.edu.my/id/eprint/41068/ Menopausal hormone therapy and risk of venous thromboembolism: the story so far Mohsen M.A. Abdelhafez Karim A. M. Ahmed Nashwa A.M. Ahmed Mohd H. Ismail Mohd Nazri Mohd Daud Aya M. Eldiastey Mohd Fariz Amri Mohammad Saffree Jeffree Fairrul Masnah @ Kadir Dg Marshitah Pg Baharuddin Mohammad Firdaus Bolong @ Mohd Darwis Mohd Firdaus Hayati Nornazirah Azizan Doreen Sumpat Syed Sharizman Syed Abdul Rahim Win W. Than Mohd Y. Ibrahim Zhen Z. Lo May, Zaw Soe R5-920 Medicine (General) RG159-208 Functional and systemic disorders. Endocrine gynecology Menopausal hormone therapy (MHT) is known to increase the risk of venous thromboembolism (VTE), which includes deep vein thrombosis, pulmonary embolism, and less frequently cerebral vein thrombosis, but the absolute risk for a given patient is very low. After starting MHT, the risk of VTE seems to be at its highest, declining to the non-HRT user baseline level of risk after stopping. Whether estrogen-only or estrogen-progestin HRT combination is linked to a similar risk of VTE is unclear from the available evidence. The aim of this study is to evaluate the risks of developing VTE in relation to different types as well as different modes of administration of MHT through a database search including PubMed, MEDLINE, Google Scholar, Cochrane Library, and others in order to provide the women carers with the up-to-date and evidence-based guidelines and recommendations while counseling the post-menopausal women enquiring on use of hormonal therapies either to alleviate the menopausal symptoms or to prevent the longterm sequelae of estrogen deficiency. African Journal of Reproductive Health/Women's Health and Action Research Centre (WHARC) 2024-03 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/41068/3/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/41068/2/FULL%20TEXT.pdf Mohsen M.A. Abdelhafez and Karim A. M. Ahmed and Nashwa A.M. Ahmed and Mohd H. Ismail and Mohd Nazri Mohd Daud and Aya M. Eldiastey and Mohd Fariz Amri and Mohammad Saffree Jeffree and Fairrul Masnah @ Kadir and Dg Marshitah Pg Baharuddin and Mohammad Firdaus Bolong @ Mohd Darwis and Mohd Firdaus Hayati and Nornazirah Azizan and Doreen Sumpat and Syed Sharizman Syed Abdul Rahim and Win W. Than and Mohd Y. Ibrahim and Zhen Z. Lo and May, Zaw Soe (2024) Menopausal hormone therapy and risk of venous thromboembolism: the story so far. African Journal of Reproductive Health, 28. pp. 122-129. ISSN 2141-3606 |
| spellingShingle | R5-920 Medicine (General) RG159-208 Functional and systemic disorders. Endocrine gynecology Mohsen M.A. Abdelhafez Karim A. M. Ahmed Nashwa A.M. Ahmed Mohd H. Ismail Mohd Nazri Mohd Daud Aya M. Eldiastey Mohd Fariz Amri Mohammad Saffree Jeffree Fairrul Masnah @ Kadir Dg Marshitah Pg Baharuddin Mohammad Firdaus Bolong @ Mohd Darwis Mohd Firdaus Hayati Nornazirah Azizan Doreen Sumpat Syed Sharizman Syed Abdul Rahim Win W. Than Mohd Y. Ibrahim Zhen Z. Lo May, Zaw Soe Menopausal hormone therapy and risk of venous thromboembolism: the story so far |
| title | Menopausal hormone therapy and risk of venous thromboembolism: the story so far |
| title_full | Menopausal hormone therapy and risk of venous thromboembolism: the story so far |
| title_fullStr | Menopausal hormone therapy and risk of venous thromboembolism: the story so far |
| title_full_unstemmed | Menopausal hormone therapy and risk of venous thromboembolism: the story so far |
| title_short | Menopausal hormone therapy and risk of venous thromboembolism: the story so far |
| title_sort | menopausal hormone therapy and risk of venous thromboembolism the story so far |
| topic | R5-920 Medicine (General) RG159-208 Functional and systemic disorders. Endocrine gynecology |
| url | https://eprints.ums.edu.my/id/eprint/41068/3/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/41068/2/FULL%20TEXT.pdf |
| work_keys_str_mv | AT mohsenmaabdelhafez menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT karimamahmed menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT nashwaamahmed menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mohdhismail menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mohdnazrimohddaud menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT ayameldiastey menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mohdfarizamri menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mohammadsaffreejeffree menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT fairrulmasnahkadir menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT dgmarshitahpgbaharuddin menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mohammadfirdausbolongmohddarwis menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mohdfirdaushayati menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT nornazirahazizan menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT doreensumpat menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT syedsharizmansyedabdulrahim menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT winwthan menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mohdyibrahim menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT zhenzlo menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar AT mayzawsoe menopausalhormonetherapyandriskofvenousthromboembolismthestorysofar |