Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series
A third of patients with non-Hodgkin’s lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma-related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the...
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| Format: | Article |
| Language: | English English |
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John Wiley & Sons Australia, Ltd
2024
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| Online Access: | https://eprints.ums.edu.my/id/eprint/42163/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/42163/2/FULL%20TEXT.pdf |
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| author | Huan, Nai-Chien Ng, Khai Lip Larry Ellee Nyanti Khaw, Jing Yi Lee, Jiun Hang Nur Husna Mohd Aminudin Dahziela Yunus Nusaibah Azman Maryam Ahmad Sharifuddin Hema Yamini Ramarmuty Kunji Kannan Sivaraman Kannan |
| author_facet | Huan, Nai-Chien Ng, Khai Lip Larry Ellee Nyanti Khaw, Jing Yi Lee, Jiun Hang Nur Husna Mohd Aminudin Dahziela Yunus Nusaibah Azman Maryam Ahmad Sharifuddin Hema Yamini Ramarmuty Kunji Kannan Sivaraman Kannan |
| author_sort | Huan, Nai-Chien |
| collection | UMS |
| description | A third of patients with non-Hodgkin’s lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma-related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the other hand, primary pleural lymphomas (PPLs) exhibit exclusive or dominant involvement of serous cavities, without detectable solid tumour masses. PPL is an uncommon disease and is of two types: primary effusion lymphoma (PEL) and diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI). PPLs not related to PELs and DLBCL-CIs are exceedingly rare. Herein, we describe four patients with biopsy proven B-cell NHL. One had no extra-pleural involvement at the time of diagnosis, indicating PPL. In all cases, histopathological examination of pleural biopsies obtained via medical thoracoscopy (MT) were crucial in clinching the final diagnosis. Clinicians are alerted to the potential relationship between exudative effusion and NHL as well as the role of MT in the diagnosis of B-cell NHL. |
| first_indexed | 2025-03-05T01:34:07Z |
| format | Article |
| id | ums.eprints-42163 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2025-03-05T01:34:07Z |
| publishDate | 2024 |
| publisher | John Wiley & Sons Australia, Ltd |
| record_format | dspace |
| spelling | ums.eprints-421632024-12-16T02:59:14Z https://eprints.ums.edu.my/id/eprint/42163/ Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series Huan, Nai-Chien Ng, Khai Lip Larry Ellee Nyanti Khaw, Jing Yi Lee, Jiun Hang Nur Husna Mohd Aminudin Dahziela Yunus Nusaibah Azman Maryam Ahmad Sharifuddin Hema Yamini Ramarmuty Kunji Kannan Sivaraman Kannan R5-920 Medicine (General) RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens A third of patients with non-Hodgkin’s lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma-related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the other hand, primary pleural lymphomas (PPLs) exhibit exclusive or dominant involvement of serous cavities, without detectable solid tumour masses. PPL is an uncommon disease and is of two types: primary effusion lymphoma (PEL) and diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI). PPLs not related to PELs and DLBCL-CIs are exceedingly rare. Herein, we describe four patients with biopsy proven B-cell NHL. One had no extra-pleural involvement at the time of diagnosis, indicating PPL. In all cases, histopathological examination of pleural biopsies obtained via medical thoracoscopy (MT) were crucial in clinching the final diagnosis. Clinicians are alerted to the potential relationship between exudative effusion and NHL as well as the role of MT in the diagnosis of B-cell NHL. John Wiley & Sons Australia, Ltd 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/42163/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/42163/2/FULL%20TEXT.pdf Huan, Nai-Chien and Ng, Khai Lip and Larry Ellee Nyanti and Khaw, Jing Yi and Lee, Jiun Hang and Nur Husna Mohd Aminudin and Dahziela Yunus and Nusaibah Azman and Maryam Ahmad Sharifuddin and Hema Yamini Ramarmuty and Kunji Kannan Sivaraman Kannan (2024) Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series. Respirology Case Reports, 12. pp. 1-6. ISSN 2051-3380 https://doi.org/10.1002/rcr2.70061 |
| spellingShingle | R5-920 Medicine (General) RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Huan, Nai-Chien Ng, Khai Lip Larry Ellee Nyanti Khaw, Jing Yi Lee, Jiun Hang Nur Husna Mohd Aminudin Dahziela Yunus Nusaibah Azman Maryam Ahmad Sharifuddin Hema Yamini Ramarmuty Kunji Kannan Sivaraman Kannan Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series |
| title | Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series |
| title_full | Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series |
| title_fullStr | Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series |
| title_full_unstemmed | Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series |
| title_short | Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series |
| title_sort | utilizing medical thoracoscopy for the diagnosis of b cell lymphoma presenting with pleural effusion a case series |
| topic | R5-920 Medicine (General) RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| url | https://eprints.ums.edu.my/id/eprint/42163/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/42163/2/FULL%20TEXT.pdf |
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